Why Little Ronny Can't Read, Rite, Remember or Run
 

Dietary trans-fat combined with monosodium glutamate induces
dyslipidemia and impairs spatial memory.

Effect of trans-fat, fructose and monosodium glutamate feeding on
feline weight gain, adiposity, insulin sensitivity, adipokine and
lipid profile.
The incidence of obesity and type 2 diabetes mellitus (T2DM) is
increasing, and new experimental models are required to investigate
the diverse aspects of these polygenic diseases, which are intimately
linked in terms of aetiology. Feline T2DM has been shown to closely
resemble human T2DM in terms of its clinical, pathological and
physiological features. Our aim was to develop a feline model of diet-
induced weight gain, adiposity and metabolic deregulation, and to
examine correlates of weight and body fat change, insulin homeostasis,
lipid profile, adipokines and clinical chemistry, in order to study
associations which may shed light on the mechanism of diet-induced
metabolic dysregulation. We used a combination of partially
hydrogenated vegetable shortening and high-fructose corn syrup to
generate a high-fat-high-fructose diet. The effects of this diet were
compared with an isoenergetic standard chow, either in the presence or
absence of 1·125 % dietary monosodium glutamate (MSG). Dual-energy X-
ray absorptiometry body imaging and a glucose tolerance test were
performed. The present results indicate that dietary MSG increased
weight gain and adiposity, and reduced insulin sensitivity (P 0·05),
whereas high-fat-high-fructose feeding resulted in elevated cortisol
and markers of liver dysfunction (P 0·01). The combination of all
three dietary constituents resulted in lower insulin levels and
elevated serum â-hydroxybutyrate and cortisol (P 0·05). This
combination also resulted in a lower first-phase insulin release
during glucose tolerance testing (P 0·001). In conclusion, markers
of insulin deregulation and metabolic dysfunction associated with
adiposity and T2DM can be induced by dietary factors in a feline
model. PMID: 21429276