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Old August 13th, 2004, 03:23 PM
Doug Freyburger
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Default Can a low-carb diet fail if you take in too many calories?

jamie wrote:
Hannah Gruen wrote:

And the body's releasing insulin takes you out of ketosis....
how? Could you provide some kind of backup on this please?


Ketosis is driven by the hormone glucagon. More glucagon in the
blood, more fat withdrawn from storage. Glucagon is released in
indirect response to dietary fat through a feedback loop using
changing levels of adreniline in the blood. Ketosis is indirectly
suppressed by the hormone insulin. Insulin in the blood suppresses
glucagon release. More insulin in the blood, less glucagon in
the blood, less fat withdrawn from storage.

In persons capable of producing insulin (not Type I diabetics), there
are feedback mechanisms to prevent blood ketone levels going too high
and causing ketoacidosis. The body slows or stops metabolizing fats,
and releases insulin to use glucose (if not from carb, then from
gluconeogenesis breakdown of proteins).


That's the key. Dietary carbs directly trigger insulin release.
A large excess of dietary fat will also trigger insulin release.

Switch from eating little fat to eating plenty and you are likely
to have more glucagon in your blood and withdraw more fat from
storage. Go too fat and over eat getting far too much fat and
you will release insulin and stop the withdrawal of stored fat.

Have you noticed folks worrying about eating enough dietary fat
to burn that instead of stored fat? It happens, just at higher
fat intake levels than most expect. That's along the transition
to massive over eating of fat that knocks you out of ketosis.