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Old June 9th, 2005, 04:25 PM
Michael C Price
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Another interesting study:

J Nutr. 2004 Mar;134(3):586-91.

High-protein, low-fat diets are effective for weight loss and favorably
alter biomarkers in healthy adults.

Johnston CS, Tjonn SL, Swan PD.

Department of Nutrition, Arizona State University, Mesa, AZ 85212, USA.


Although popular and effective for weight loss, low-carbohydrate,
high-protein, high-fat (Atkins) diets have been associated with adverse
changes in blood and renal biomarkers. High-protein diets low in fat may
represent an equally appealing diet plan but promote a more healthful weight
loss. Healthy adults (n = 20) were randomly assigned to 1 of 2 low-fat (30%
energy), energy-restricted groups: high-protein (30% energy) or
high-carbohydrate (60% energy); 24-h intakes were strictly controlled during
the 6-wk trial. One subject from each group did not complete the trial due
to out-of-state travel; two subjects in the high-carbohydrate group withdrew
from the trial due to extreme hunger. Body composition and metabolic indices
were assessed pre- and post-trial. Both diets were equally effective at
reducing body weight (-6%, P 0.05) and fat mass (-9 to -11%, P 0.05);
however, subjects consuming the high-protein diet reported more satisfaction
and less hunger in mo 1 of the trial. Both diets significantly lowered total
cholesterol (-10 to -12%), insulin (-25%), and uric acid (-22 to -30%)
concentrations in blood from fasting subjects. Urinary calcium excretion
increased 42% in subjects consuming the high-protein diet, mirroring the 50%
increase in dietary calcium with consumption of this diet; thus, apparent
calcium balance was not adversely affected. Creatinine clearance was not
altered by diet treatments, and nitrogen balance was more positive in
subjects consuming the high-protein diet vs. the high-carbohydrate diet (3.9
+/- 1.4 and 0.7 +/- 1.7 g N/d, respectively, P 0.05). Thus, low-fat,
energy-restricted diets of varying protein content (15 or 30% energy)
promoted healthful weight loss, but diet satisfaction was greater in those
consuming the high-protein diet.

Publication Types:
Clinical Trial
Randomized Controlled Trial

PMID: 14988451
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Cheers,
Michael C Price
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