citation for the above?

Dioxin: a review of its environmental effects and its aryl hydrocarbon
receptor biology.
A highly persistent trace environmental contaminant and one of the
most potent toxicants known is dioxin (2,3,7,8-tetrachlorodibenzo-para-
dioxin or TCDD). TCDD induces a broad spectrum of biological
responses, including induction of cytochrome P-450 1A1 (CYP1A1),
disruption of normal hormone signaling pathways, reproductive and
developmental defects, immunotoxicity, liver damage, wasting syndrome,
and cancer. Its classification was upgraded from "possible human
carcinogen" (group 2B) to "human carcinogen" (group 1) by the
International Agency for Research on Cancer (IARC) in 1997. Exposure
to TCDD may also cause changes in sex ratio, and tumor promotion in
other animals. Because of the growing public and scientific concern,
toxicological studies have been initiated to analyze the short- and
long-term effects of dioxin. TCDD brings about a wide variety of toxic
and biochemical effects via aryl hydrocarbon receptor (AhR)-mediated
signaling pathways. Essential steps in this adaptive mechanism include
AhR binding of ligand in the cytoplasm of cells associated with two
molecules of chaperone heatshock protein (Hsp90) and AhR interactive
protein, translocation of the receptor to the nucleus, dimerization
with the Ah receptor nuclear translocator, and binding of this
heterodimeric transcription factor (present in CYP1A) to dioxin-
responsive elements upstream of promoters that regulate the expression
of genes involved in xenobiotic metabolism. PMID: 15900503