On Wed, 25 Feb 2004 12:05:40 -0600, Lyle McDonald wrote:
Diarmid Logan wrote:

http://www.eurekalert.org/pub_releas...-cos022504.php

Carbohydrates offer some help in muscle protein synthesis, but not
enough for the desired effect


This comes to you from the Dept. of No **** we Knew this 10 years ago
Sherlock. The only confusion comes in that carbs don't appear to affect
protein SYNTHESIS (an increase in insulin prmiarily affecting protein
breakdown, decreasing it). HIgh AA concentrations stimulate protein
synthesis. Cobmining the two (high insulin + high AA) gives better
results, something that's been known for years.

But thanks for being on the cutting edge of about 1995 or so.

Lyle


Lyle is right. It is 'old news.'
Tipton/Wolfe and Ferrando, the protein metabolism kings ("We're all
about protein metabolism" - private conversation), have demonstrated
that AAs are superior over carbs for protein synthesis. In fact, a
colleague of theirs demonstrated that simultaneous intake of carbs
WITH AAs actually reduces protein synthesis in elderly compared to AA
intake alone. (study published last year).

The signaling pathway downstream of the insulin receptor in muscle
diverges from that which induces protein synthesis, and leads to a
reduction in the catabolic pathway of protein. Hence, the reason that
the studies demonstrate that insulin reduces catabolism, but does not
significantly increase protein synthesis.


Beelzibub

The human in us owes fealty to humanity. But the wolf in us acknowledges no master.