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Binge eating caused by faulty gene, sometimes
On Tue, 3 Aug 2004 21:18:15 +0200, "Lictor"
wrote: "janice" wrote in message .. . The article refers to a pill to tame the appetite. My experience of bingeing is that it has very little to do with hunger or appetite and a lot to do with what goes on in the mind. Same here... I have found out that actually listening to my appetite and hunger (which is easier said than done) makes serious bingeing virtually impossible. Now, bingeing means eating that extra yogourt without being hungry - more than that and I feel so unwell I don't feel like eating more. Bingeing is only possible when your unconscious mind managers to completely obliterate the proper signalling your brain gets from your body; and it's actually trully impressive how powerful and efficient the unconscious mind is at performing that trick. That's also a purely psychological trick. I needed no meds to do it, and I needed no meds to re-learn how to detect when I have had my fill... I would not take any pill to tame my appetite... Appetite is my friend, it tells me when to eat and when to stop Yes, Lictor, I read your earlier post when you said this and found it interesting. I'm very aware that I don't listen to my appetite, although having said that my digestive system is a bit screwed up from years of bingeing and I don't often feel "genuine" hunger. I know that the one time I took appetite suppressants, many years ago, I still overate regardless, for reasons that presumably had nothing to do with hunger. I would never take them again, they teach you nothing. I'm glad you seem to have found the right way, although you make it sound rather easy but I'm sure it hasn't been. janice 233/181/133 |
#12
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Binge eating caused by faulty gene, sometimes
"janice" wrote in message
... I'm glad you seem to have found the right way, although you make it sound rather easy but I'm sure it hasn't been. It depends on where you start... If you start right at the time when I decided to lose weight, it was rather easy actually. If you include the panic attacks and dealing with them in the years before, the depression periods, quitting my two packs of cigarette a day and stuff like that, it wasn't so easy... The great discovery was to find that all these were linked together. And that by addressing the depression, I was also dealing with over-eating. Or that quitting the cigarette actually taught me about my eating habits. I think I started with trying to lose weight when I was ready to do so, a lot had been done silently beforehand. Another factor is that I haven't done many diets before. So, I only had my own faults to deal with, I didn't have to deal with those of several nutritionnists and fad diets... That also helped a bunch... |
#13
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Binge eating caused by faulty gene, sometimes
"janice" wrote in message
... I'm glad you seem to have found the right way, although you make it sound rather easy but I'm sure it hasn't been. It depends on where you start... If you start right at the time when I decided to lose weight, it was rather easy actually. If you include the panic attacks and dealing with them in the years before, the depression periods, quitting my two packs of cigarette a day and stuff like that, it wasn't so easy... The great discovery was to find that all these were linked together. And that by addressing the depression, I was also dealing with over-eating. Or that quitting the cigarette actually taught me about my eating habits. I think I started with trying to lose weight when I was ready to do so, a lot had been done silently beforehand. Another factor is that I haven't done many diets before. So, I only had my own faults to deal with, I didn't have to deal with those of several nutritionnists and fad diets... That also helped a bunch... |
#14
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Binge eating caused by faulty gene, sometimes
On 2 Aug 2004 17:21:54 GMT, Ignoramus2586
wrote: Binge-eating not solely caused by poor willpower, a weak gene helped: study I wrote this study up about a year or so ago when it came out. The melanocortin-4 receptor IMC4R) mutation is the most common genetic cause of obesity. The reason for this is that it's dominantly inherited, i.e., you only need one allele of the gene to have the mutation expressed. There are many variations of the mutation, and some result in more obesity than others. In the study researchers found that the subjects with the mutation had a higher prevalence of binge eating disorder (BED) than those without the mutation. However, since the researchers were looking for a reason for the obesity, they did not report data on any subjects with bulimia. Therefore, it can't be concluded from the article that bingeing and purging are related to MC4R. However, just because many people with BED are free of the MC4R mutation does not mean they don't have another unknown genetic reason for the behavior. All causes of obesity have an environmental and a genetic component. In some cases, the genetic component is so overwhelming that it is all but impossible to control the obesity (i.e., leptin mutations, leptin receptor mutations) and in others, it is fairly easy to contain with extra effort. FWIW, Barbara Hirsch, Publisher OBESITY MEDS AND RESEARCH NEWS The latest in obesity research and weight loss drug development http://www.obesity-news.com/ |
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Binge eating caused by faulty gene, sometimes
On 2 Aug 2004 17:21:54 GMT, Ignoramus2586
wrote: Binge-eating not solely caused by poor willpower, a weak gene helped: study I wrote this study up about a year or so ago when it came out. The melanocortin-4 receptor IMC4R) mutation is the most common genetic cause of obesity. The reason for this is that it's dominantly inherited, i.e., you only need one allele of the gene to have the mutation expressed. There are many variations of the mutation, and some result in more obesity than others. In the study researchers found that the subjects with the mutation had a higher prevalence of binge eating disorder (BED) than those without the mutation. However, since the researchers were looking for a reason for the obesity, they did not report data on any subjects with bulimia. Therefore, it can't be concluded from the article that bingeing and purging are related to MC4R. However, just because many people with BED are free of the MC4R mutation does not mean they don't have another unknown genetic reason for the behavior. All causes of obesity have an environmental and a genetic component. In some cases, the genetic component is so overwhelming that it is all but impossible to control the obesity (i.e., leptin mutations, leptin receptor mutations) and in others, it is fairly easy to contain with extra effort. FWIW, Barbara Hirsch, Publisher OBESITY MEDS AND RESEARCH NEWS The latest in obesity research and weight loss drug development http://www.obesity-news.com/ |
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Binge eating caused by faulty gene, sometimes
On 4 Aug 2004 20:13:14 GMT, Ignoramus11472
wrote: That implies that a person with IMC4R mutation must have one parent with same mutation that manifests itself in the parent's phenotype, right? Yes. Didn't the study imply that 1/4 of the cases of bingeing involve MC4R mutation? (all people with the mutation were binging, IIRC) No, not all people with the mutation had binge eating disorder. The percentage was higher. Barbara Hirsch, Publisher OBESITY MEDS AND RESEARCH NEWS The latest in obesity research and weight loss drug development http://www.obesity-news.com/ |
#17
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Binge eating caused by faulty gene, sometimes
On 4 Aug 2004 20:13:14 GMT, Ignoramus11472
wrote: That implies that a person with IMC4R mutation must have one parent with same mutation that manifests itself in the parent's phenotype, right? Yes. Didn't the study imply that 1/4 of the cases of bingeing involve MC4R mutation? (all people with the mutation were binging, IIRC) No, not all people with the mutation had binge eating disorder. The percentage was higher. Barbara Hirsch, Publisher OBESITY MEDS AND RESEARCH NEWS The latest in obesity research and weight loss drug development http://www.obesity-news.com/ |
#18
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Binge eating caused by faulty gene, sometimes
On 5 Aug 2004 01:59:26 GMT, Ignoramus11472
wrote: In article , Barbara Hirsch wrote: On 4 Aug 2004 20:13:14 GMT, Ignoramus11472 wrote: That implies that a person with IMC4R mutation must have one parent with same mutation that manifests itself in the parent's phenotype, right? Yes. For clarification. If the parent has 1 gene for the MCR4 mutation there is a 50/50 chance the child will inherit it (assuming the other parent is not affected). If the parent has both genes, the chance is 100 percent. Barbara Hirsch, Publisher OBESITY MEDS AND RESEARCH NEWS The latest in obesity research and weight loss drug development http://www.obesity-news.com/ |
#19
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On 5 Aug 2004 01:59:26 GMT, Ignoramus11472
wrote: In article , Barbara Hirsch wrote: On 4 Aug 2004 20:13:14 GMT, Ignoramus11472 wrote: That implies that a person with IMC4R mutation must have one parent with same mutation that manifests itself in the parent's phenotype, right? Yes. For clarification. If the parent has 1 gene for the MCR4 mutation there is a 50/50 chance the child will inherit it (assuming the other parent is not affected). If the parent has both genes, the chance is 100 percent. Barbara Hirsch, Publisher OBESITY MEDS AND RESEARCH NEWS The latest in obesity research and weight loss drug development http://www.obesity-news.com/ |
#20
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Binge eating caused by faulty gene, sometimes
Barbara Hirsch wrote:
I wrote this study up about a year or so ago when it came out. The melanocortin-4 receptor IMC4R) mutation is the most common genetic cause of obesity. The reason for this is that it's dominantly inherited, i.e., you only need one allele of the gene to have the mutation expressed. There are many variations of the mutation, and some result in more obesity than others. 1) It's different mutations within one gene rather than many variations of the mutation. 2) Some of these mutations are dominant, others are not: http://www.jci.org/cgi/content/full/106/2/271 3) There are even combinations that predispose carriers to obesity in the heterozygote state -- one would need two different mutations for the obesity risk to increase: http://www.jci.org/cgi/content/full/106/2/185 DZ In the study researchers found that the subjects with the mutation had a higher prevalence of binge eating disorder (BED) than those without the mutation. However, since the researchers were looking for a reason for the obesity, they did not report data on any subjects with bulimia. Therefore, it can't be concluded from the article that bingeing and purging are related to MC4R. However, just because many people with BED are free of the MC4R mutation does not mean they don't have another unknown genetic reason for the behavior. All causes of obesity have an environmental and a genetic component. In some cases, the genetic component is so overwhelming that it is all but impossible to control the obesity (i.e., leptin mutations, leptin receptor mutations) and in others, it is fairly easy to contain with extra effort. FWIW, Barbara Hirsch, Publisher OBESITY MEDS AND RESEARCH NEWS The latest in obesity research and weight loss drug development http://www.obesity-news.com/ |
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