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What it all does to us.......
I am Laurence Harris. I live near Seattle, Washington, USA. I have Celiac
Disorder, Hashimoto's Thyroiditis, and about five other brushes with autoimmune disorders. I have a BS degree, have read extensively in chemistry, biochemistry, and broad ranging medical research topics. I have been creating software for computers embedded in medical devices. Most recently, software to operate a Left Ventricular Assist Device - a heart pump, which is now successfully operating in at least two humans to good effect. After learning about the various medical problems that are associated with gluten sensitive enteropathy, I saw a real puzzle staring at me. It became a real teaser to me, and the more I learned, the more there seemed to be to chase down. Since I have a lot of time available, I have jumped in with both feet. I have now spent months researching issues regarding how it is that many people get AutoImmune Disorders, including Celiac Disease, Thyroiditis and a whole host of others. The linking of concepts presented here is my own invention, although all the underlying technology is from the credible published technical works of many others. I have relied only on legitimate sources, mostly medical journal articles, although some comes from informational websites put up by various professors at universities. Some of my information has come from years of reading and study, although I have attempted to find current references for most of it since science forges on. I am inserting a huge list of website references at the end of the text. They are the resources I used for most of my studies. Some of the websites allow you to download entire journal articles as PDFs to store on your hard drive. I do that wherever I can, since that works better than viewing them in your browser. Unfortunately they are not grouped by topic, nor are they in any particular order. To use many of them you must open the website and drill down into areas having research papers, journal articles, patient information and so on. There may be a few that require you to register to be able to access the technical content. The basic picture is that many people, more than have celiac disorder, have an immune system that reacts to some parts of the gluten protein in wheat, barley and rye. They interpret the protein as "enemy" - an antigen - just as though it were a bacterium or virus. Since the immune system reacts to foreign objects penetrating the skin, perhaps this explains why. To follow all this you may want to go to some of the websites and read on peptides, immune system, lymphocytes, acute and chronic inflammation. The Immune System The human body has wonderful ways of protecting itself. The system of interacting parts that defends us from invading bacteria, fungi, viruses and other foreign matter is collectively referred to as the "immune system". The tale we are telling here is one not of allergies (IgE antibodies), but one of a different, more insidious kind of immune system activity, (IgA, IgG and IgM antibodies). The immune system includes cells circulating in the blood and lymph and cells in various other places as well. It includes a variety of cell types from those that are self-moving blob-like hunter-killer cells (macrophages) to several kinds of miniature chemical factories with some making destructive toxins and others making specially shaped "antibodies" that match up to and latch onto the fairly unique cell-surface chemicals used by attacking organisms as tools or protective cover. Blood serum, T-cells, B-cells, macrophages, antibodies, bone marrow, spleen, lymphatic system, and various other organs all work together to detect and destroy invasion forces. It has taken many millions of hours of research and study for us to come as far as we have in our understanding of what happens when a bacterium or virus attempts to invade our bodies. And while we have a lot of the picture we are still learning, still searching for missing pieces to this magnificent puzzle. Cells What we do know is that nearly every type of human cell encases fluids in a cell wall made of a smooth, waterproof, very flexible double-layer of loosely coupled rod-like molecules we call a plasma membrane. The cell wall has various special structures embedded in it to transport materials across the barrier. That is how food energy gets in and how waste products get out. Inside each cell are a variety of different structures; some are tiny chemical factories that convert glucose to ready-to-use chemical energy, and use that energy for motion, or to create other special chemicals needed for the cell's operation. Sometimes the chemicals are to sent out into the rest of the human body for use elsewhere. Cell Identity Flags - Friend or Foe? But dotted all around on the outside of this smooth cell wall there are several types of special "identity flags" - specially shaped chemicals that are firmly anchored in the cell wall with a large specially shaped part "waving in the breeze" telling all passing observers who they are - self. It is not really quite that simplistic, but it is actually a combination of several possible types of identity markers that are recognized by cells in the immune system, telling them "Leave me alone! I'm a friend!" And different types of tissue have slightly differently shaped flags, all still self, but not quite all the same. These flags are called Human Leukocyte Antigens (HLA) proteins. Woe be unto cells, like bacteria, who don't know the right combination of markers for "friend" - the immune system learns their surface markers, creates a complimentary shaped pattern and attaches it to special proteins, called antibodies, that hook onto the foes' flags and tell the immune system "This is a bad guy! Let's take them out!" Once a particular immune system cell recognizes an invader it can trigger cells whose job is to make antibodies to reproduce and make lots more of these useful chemicals. Immune Responses Inflammation, created by the fast responders of the immune system, makes the area surrounding a detected invasion become porous, or permeable, so that antibodies and various immune system cells can "get at" the offenders. Even blood vessel walls become rather leaky. This makes surrounding tissues swell and turn red. So the various parts of the immune system work to penetrate or perforate the cell wall of an invading organism and make its insides all leak out. Some immune system cells pick up the antigens and carry them around with them like flags, telling other cells about the invader's identity. Some use the antibody's matching pattern to latch onto the invading cells' surface features (antigens) and get up against them to unleash little vesicles of destructive chemicals. Others engulf an offender and digest it, or at least they carry away indigestible stuff. Picture these blob-like macrophages, fairly big as blood cells go, slipping along in the blood stream and encountering a battle site - they send out an amoeba-like tentacle, a pseudopod, and pull themselves over to a marked offender, then they ooze around it and rejoin on the other side. When it is fully engulfed they release chemicals, right up against the bad cell, similar to chlorine bleach, that chemically take apart the proteins and lipids that make up the invader's structure. Burp. Even the lowly virus has chemical patterns that the immune system uses to identify them. Virus surface coat chemicals are really tools to make the virus stick to the surface of a human cell so they can get inside that cell. And as a virus drills through the human cell wall it leaves behind various parts of its surface coat, sort of embedded in and floating on the human cell wall. These too are sensed by the immune system and used to identify cells that are being taken over by a virus. These human cells then, are mercilessly destroyed. And the methods work. Takes about two weeks for the immune system to detect the invasion, learn the cell-surface markers left by the viruses, make enough antibody factories ( B-Cells and others ), and do the search and destroy job. When it is all done, and the antibody production shuts down, there are extra of these chemical factories circulating in the blood, sort of on standby, in case the same invaders come again. They would be able to attack and destroy them before they ever get a foothold again. That is learned immunity. Immunity Learned immunity is what we try to induce with a vaccine. A vaccine is just a whole lot of these cell surface markers without the offending bacterium or virus still attached, or at least if the cell is still there it has, hopefully, been killed. Seems to work pretty well most of the time. So we make a mixture of water with pieces of surface marker protein in it and inject it into the inside of the body. The immune system sees the invading stuff and sets up new antibody manufacturing to fight it off. Since there are no real invaders, it is easy to clean up the debris, but the result is that the immune system now has standby troops for that particular type of invader. It is much better to learn immunity without having to suffer through a full scale invasion. The Flags are Proteins So the cell surface markers are mostly bits of protein, which are really just interconnected amino acids, which have shapes unique for that kind of organism. Amino acids are some of the basic building blocks of the human body. We get amino acids from eating and digesting meats and plant materials, although some of them can be made by our own cells. Amino acids also serve as a source of food energy when needed. Depending on what order you string the amino acids together, and what other chemical bits you hook onto the chain at various places, the whole thing folds into a three dimensional shape. These proteins are sometimes referred to as "peptides". (A peptide, then is just a piece of protein.) And shape is what is used by antibodies to "recognize" a cell surface marker. Intestinal Tract The intestinal tract has a single cell layer, the epithelium that forms villi - little finger-like projections that are filled with immune system cells - lymphocytes - T cells, B cells, macrophages and so on. Below the epithelium is something called the submucosa. and under all of it, or more properly surrounding all of it is the muscular intestinal wall. When gluten is present in the intestine, these immune system cells react, and cause inflammation. Inflammation makes blood cell walls - epithelial tissue - become leaky so that plasma containing antibodies can get at the invasion more easily, along with lymphocytes. Unfortunately, the epithelial wall of the intestine becomes leakier, too. It is a positive feedback loop with inflammation. And the worse the inflammation, the more of the gluten protein segments can get in while other stuff is getting "out" into the digestive tract. Antibodies Well, one part of the immune response is to turn on the manufacture of antibodies - chemicals that physically fit like hand and glove, or plug and socket - that match up to the antigens. These little chemical factories are in the B cells. And activating a B cell with a matching antibody causes it to make antibodies and to replicate. As long as antigen is being found, the B cells will be told by the T cells and macrophages to make antibodies. Or is it the T helper cells that do this? Any way the replicators get busy and the B cells get busy, flooding the blood plasma with antibody chemicals that attach to the antigenic gluten protein. Since gluten consumes the antibodies, they have to be replaced when more gluten comes along. Fuzzy Logic Well, B cell replication is designed to not be perfect. The mechanisms that transcribe the DNA/RNA stretches that encode antibody peptide sequences have a built in randomizer that will occasionally substitute a different amino acid into the sequence than was in the original. This apparently serves the purpose of making the immune system more adaptable in case the original match was not quite perfect. And if the new antibody shapes don't match anything, they are never activated to make antibodies, and do not replicate further. So under a continuous attack from an antigen, such as gluten, the production of antibodies is always running, perhaps even in high gear. And along with this high rate of activity comes continual varying of the antibody patterns. Unfortunately, many people have self-identification cell surface marker peptides that bear a strong resemblance to gluten protein pieces. So when the random variations in antibody shapes just happen to match fairly closely with one of these usually protective Human Leukocyte Antigens (HLA), the particular type of tissue in the human organism that bears that particular variation of HLA is suddenly treated as a bad guy, as INVADER, instead of SELF. And bang! There goes the thyroid producing cells. Or the Islets of Langerhans insulin producing cells. Or any one of a whole lot of other tissue types. Endomysial tissue, a connective fibrous material surrounding muscle cells apparently is one of the targets of attack, at least as long as gluten is revving up the B cells. I'm not sure what the difference between this sort of attack that only goes on as long as gluten is being consumed and the thyroid or insulin cell attacks that seem to continue after gluten is removed. Perhaps endomysial tissue is only in out-of-the-way places that don't typically get visited by T cells or macrophages, and thus only suffer when the antibodies are being produced in large amounts to fight off gluten. That seems reasonable, since the gluten sets things going by showing up at the intestinal inner wall epithelium which is just loaded with lymphocytes to keep the fauna and flora of the inside of the intestine from getting anywhere they shouldn't. And then there is apparently endomysial tissue in the submucosa of the intestine? At any rate, the intestinal villi get destroyed after a long enough time, and since that is where a lot of digestive enzymes are produced, food doesn't get properly digested, and since the surface area is smaller, it doesn't get properly absorbed. So some of these tissue types are continually exposed to lymphocytes, and so cause a sustained attack, while others seem to be typically sheltered, and thus don't sustain antibody production when gluten is absent. And then there is the increased risk of cancer that is associated with untreated CD. Only is a problem when the immune system is churning away. Not when all is quiescent. All of this suggests that many people who never get Celiac Disease are still experiencing varying degrees of intestinal inflammation from the consumption of gluten. And there is a lot known about inflammation and its apparent linkage to heart trouble, arthritis and a whole lot of other disorders. And there are all the autoimmune disorders that seem to be the result of the churning immune system hitting the wrong combination by accident. There is even one website by a gastroenterologist suggesting that it could be sixty percent or more of mankind that experiences this immune response from gluten ingestion. Various theories have been discussed that involved trigger events to start off the attack against self causing an autoimmune disorder. I suspect that that is not necessary, although it could play some role in starting some autoimmune disorders in some people. Apparently H. Pylori bacteria, the stuff of stomach ulcers, carried by the common housefly, can maintain a chronic infection in the stomach that does the same sort of job as gluten in the intestine. At least it maintains a constant inflammatory state, and has an association with stomach cancers. And supposedly there is an immune reaction in some people to bakers yeast. So what to make of all of this? I think that because there is legitimate research published about the increased risk of cancer in untreated Celiac Disease (CD) patients, and that we have, in the US, only identified about three per cent of those that actually have CD, that one could honestly make a statement. about the safety of consuming gluten from wheat, barley or rye. ================================================== =========== STATEMENT "Since the ingestion of gluten from wheat, barley or rye has been demonstrated, through clinical studies with humans, to cause an elevated risk of cancer, gluten from wheat, barley and rye should be declared a CARCINOGENIC SUBSTANCES. 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(c) AMA 1996 http://www.ama-assn.org/sci-pubs/jou..._10/sc4291.htm Specialty Laboratories - clinical reference laboratory contract research organization http://www.specialtylabs.com/ StopAllergy.com Ask an Allergist http://allergist.stopallergy.com/For...lth/Allergist/ Support Groups http://www.whatnowheat.com/Support%20Groups.htm Swedish Medical Center Home http://www.swedish.org/home.asp?Home The American Gastroenterological Association - Clinical Resources (Patient Brochures) http://www.gastro.org/clinicalRes/brochures/ibd.html The American Gastroenterological Association http://www.gastro.org/ The Antibody Resource Page educational http://www.antibodyresource.com/educational.html The Gluten Free Kitchen http://gfkitchen.server101.com/ The gluten free message board http://members2.boardhost.com/gluten...html?999235741 The Great Plains Laboratory, your center of testing and analysis for Autism, Pervasive Developmental Disorder (PDD) http://www.greatplainslaboratory.com/immune.html The Merck Manual http://www.merck.com/pubs/ The National Fibromyalgia Association http://www.fmaware.org/ Thinner - guide to lowcarb weight loss http://www.thinner.com/ ThirdAge - Health Newsletter - Overlooked, Under-Diagnosed Thyroid Disease Poses a Challenge http://www.thirdage.com/news/article...040326-01.html Thyroid Disease Manager, your source on thyroid disease, hyperthyroidism, hypothyroidism, thyroiditis,thyroid cancer http://www.thyroidmanager.org/ Thyroid Disease Symptoms - Hypothyroidism Symptoms http://www.armourthyroid.com/hypothy.../symptoms.html TNFA promoter polymorphism and susceptibility to brucellosis - Clin Exp Immunol, Vol 121, Issue 3, pp. 480-483 (Full Text) http://www.blackwell-synergy.com/lin....01331.x/full/ Two distinct hemolysins in Trichomonas tenax ATCC 30207 - Oral Microbiol Immunol, Vol 15, Issue 6, pp. 355-359 (Abstract) http://www.blackwell-synergy.com/lin...d=bHR8zMK2xU2f USDA NutrientDatabase http://www.nal.usda.gov/fnic/foodcomp/search/ Van's Wheat Free Waffles. http://www.vansintl.com/wheatfree.php VCUendomysiumResident Cases http://www.pathology.vcu.edu/WirSelfInst/muscle.html virus-adeno http://www.stanford.edu/group/virus/adeno/adeno.html Voluntary Recall of Taco Bell Taco Shells containing StarLink Corn http://www.cast-science.org/cast-sci...y/20000925.htm WAFDO http://www.wafdo.org/ WebRing hub http://j.webring.com/hub?ring=celiac Welcome to Medscape http://www.medscape.com/px/urlinfo Welcome to MedWeb http://medweb.bham.ac.uk/ Welcome to the Gluten Intolerance Group of North America http://www.gluten.net/ Welcome to the Incredible Edible Egg Website http://www.aeb.org/ www.patientcenters.com -- Non-Hodgkin's Lymphoma Center -- What are the NHLs http://www.patientcenters.com/lymphoma/news/nhl2.html York Nutritional Laboratories, Inc... Better health begins at home http://www.yorkallergyusa.com/ [Report] Treatment Algorithms 2000(Table of Contents) http://www.the-infoshop.com/study/dc...rithm_toc.html ================================================== =========== |
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What it all does to us.......
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L O N K "Laurence" lharris@nwlinkDOTcom wrote in message ... I am Laurence Harris. I live near Seattle, Washington, USA. I have Celiac Disorder, Hashimoto's Thyroiditis, and about five other brushes with autoimmune disorders. I have a BS degree, have read extensively in chemistry, biochemistry, and broad ranging medical research topics. I have been creating software for computers embedded in medical devices. Most recently, software to operate a Left Ventricular Assist Device - a heart pump, which is now successfully operating in at least two humans to good effect. After learning about the various medical problems that are associated with gluten sensitive enteropathy, I saw a real puzzle staring at me. It became a real teaser to me, and the more I learned, the more there seemed to be to chase down. Since I have a lot of time available, I have jumped in with both feet. I have now spent months researching issues regarding how it is that many people get AutoImmune Disorders, including Celiac Disease, Thyroiditis and a whole host of others. The linking of concepts presented here is my own invention, although all the underlying technology is from the credible published technical works of many others. I have relied only on legitimate sources, mostly medical journal articles, although some comes from informational websites put up by various professors at universities. Some of my information has come from years of reading and study, although I have attempted to find current references for most of it since science forges on. I am inserting a huge list of website references at the end of the text. They are the resources I used for most of my studies. Some of the websites allow you to download entire journal articles as PDFs to store on your hard drive. I do that wherever I can, since that works better than viewing them in your browser. Unfortunately they are not grouped by topic, nor are they in any particular order. To use many of them you must open the website and drill down into areas having research papers, journal articles, patient information and so on. There may be a few that require you to register to be able to access the technical content. The basic picture is that many people, more than have celiac disorder, have an immune system that reacts to some parts of the gluten protein in wheat, barley and rye. They interpret the protein as "enemy" - an antigen - just as though it were a bacterium or virus. Since the immune system reacts to foreign objects penetrating the skin, perhaps this explains why. To follow all this you may want to go to some of the websites and read on peptides, immune system, lymphocytes, acute and chronic inflammation. The Immune System The human body has wonderful ways of protecting itself. The system of interacting parts that defends us from invading bacteria, fungi, viruses and other foreign matter is collectively referred to as the "immune system". The tale we are telling here is one not of allergies (IgE antibodies), but one of a different, more insidious kind of immune system activity, (IgA, IgG and IgM antibodies). The immune system includes cells circulating in the blood and lymph and cells in various other places as well. It includes a variety of cell types from those that are self-moving blob-like hunter-killer cells (macrophages) to several kinds of miniature chemical factories with some making destructive toxins and others making specially shaped "antibodies" that match up to and latch onto the fairly unique cell-surface chemicals used by attacking organisms as tools or protective cover. Blood serum, T-cells, B-cells, macrophages, antibodies, bone marrow, spleen, lymphatic system, and various other organs all work together to detect and destroy invasion forces. It has taken many millions of hours of research and study for us to come as far as we have in our understanding of what happens when a bacterium or virus attempts to invade our bodies. And while we have a lot of the picture we are still learning, still searching for missing pieces to this magnificent puzzle. Cells What we do know is that nearly every type of human cell encases fluids in a cell wall made of a smooth, waterproof, very flexible double-layer of loosely coupled rod-like molecules we call a plasma membrane. The cell wall has various special structures embedded in it to transport materials across the barrier. That is how food energy gets in and how waste products get out. Inside each cell are a variety of different structures; some are tiny chemical factories that convert glucose to ready-to-use chemical energy, and use that energy for motion, or to create other special chemicals needed for the cell's operation. Sometimes the chemicals are to sent out into the rest of the human body for use elsewhere. Cell Identity Flags - Friend or Foe? But dotted all around on the outside of this smooth cell wall there are several types of special "identity flags" - specially shaped chemicals that are firmly anchored in the cell wall with a large specially shaped part "waving in the breeze" telling all passing observers who they are - self. It is not really quite that simplistic, but it is actually a combination of several possible types of identity markers that are recognized by cells in the immune system, telling them "Leave me alone! I'm a friend!" And different types of tissue have slightly differently shaped flags, all still self, but not quite all the same. These flags are called Human Leukocyte Antigens (HLA) proteins. Woe be unto cells, like bacteria, who don't know the right combination of markers for "friend" - the immune system learns their surface markers, creates a complimentary shaped pattern and attaches it to special proteins, called antibodies, that hook onto the foes' flags and tell the immune system "This is a bad guy! Let's take them out!" Once a particular immune system cell recognizes an invader it can trigger cells whose job is to make antibodies to reproduce and make lots more of these useful chemicals. Immune Responses Inflammation, created by the fast responders of the immune system, makes the area surrounding a detected invasion become porous, or permeable, so that antibodies and various immune system cells can "get at" the offenders. Even blood vessel walls become rather leaky. This makes surrounding tissues swell and turn red. So the various parts of the immune system work to penetrate or perforate the cell wall of an invading organism and make its insides all leak out. Some immune system cells pick up the antigens and carry them around with them like flags, telling other cells about the invader's identity. Some use the antibody's matching pattern to latch onto the invading cells' surface features (antigens) and get up against them to unleash little vesicles of destructive chemicals. Others engulf an offender and digest it, or at least they carry away indigestible stuff. Picture these blob-like macrophages, fairly big as blood cells go, slipping along in the blood stream and encountering a battle site - they send out an amoeba-like tentacle, a pseudopod, and pull themselves over to a marked offender, then they ooze around it and rejoin on the other side. When it is fully engulfed they release chemicals, right up against the bad cell, similar to chlorine bleach, that chemically take apart the proteins and lipids that make up the invader's structure. Burp. Even the lowly virus has chemical patterns that the immune system uses to identify them. Virus surface coat chemicals are really tools to make the virus stick to the surface of a human cell so they can get inside that cell. And as a virus drills through the human cell wall it leaves behind various parts of its surface coat, sort of embedded in and floating on the human cell wall. These too are sensed by the immune system and used to identify cells that are being taken over by a virus. These human cells then, are mercilessly destroyed. And the methods work. Takes about two weeks for the immune system to detect the invasion, learn the cell-surface markers left by the viruses, make enough antibody factories ( B-Cells and others ), and do the search and destroy job. When it is all done, and the antibody production shuts down, there are extra of these chemical factories circulating in the blood, sort of on standby, in case the same invaders come again. They would be able to attack and destroy them before they ever get a foothold again. That is learned immunity. Immunity Learned immunity is what we try to induce with a vaccine. A vaccine is just a whole lot of these cell surface markers without the offending bacterium or virus still attached, or at least if the cell is still there it has, hopefully, been killed. Seems to work pretty well most of the time. So we make a mixture of water with pieces of surface marker protein in it and inject it into the inside of the body. The immune system sees the invading stuff and sets up new antibody manufacturing to fight it off. Since there are no real invaders, it is easy to clean up the debris, but the result is that the immune system now has standby troops for that particular type of invader. It is much better to learn immunity without having to suffer through a full scale invasion. The Flags are Proteins So the cell surface markers are mostly bits of protein, which are really just interconnected amino acids, which have shapes unique for that kind of organism. Amino acids are some of the basic building blocks of the human body. We get amino acids from eating and digesting meats and plant materials, although some of them can be made by our own cells. Amino acids also serve as a source of food energy when needed. Depending on what order you string the amino acids together, and what other chemical bits you hook onto the chain at various places, the whole thing folds into a three dimensional shape. These proteins are sometimes referred to as "peptides". (A peptide, then is just a piece of protein.) And shape is what is used by antibodies to "recognize" a cell surface marker. Intestinal Tract The intestinal tract has a single cell layer, the epithelium that forms villi - little finger-like projections that are filled with immune system cells - lymphocytes - T cells, B cells, macrophages and so on. Below the epithelium is something called the submucosa. and under all of it, or more properly surrounding all of it is the muscular intestinal wall. When gluten is present in the intestine, these immune system cells react, and cause inflammation. Inflammation makes blood cell walls - epithelial tissue - become leaky so that plasma containing antibodies can get at the invasion more easily, along with lymphocytes. Unfortunately, the epithelial wall of the intestine becomes leakier, too. It is a positive feedback loop with inflammation. And the worse the inflammation, the more of the gluten protein segments can get in while other stuff is getting "out" into the digestive tract. Antibodies Well, one part of the immune response is to turn on the manufacture of antibodies - chemicals that physically fit like hand and glove, or plug and socket - that match up to the antigens. These little chemical factories are in the B cells. And activating a B cell with a matching antibody causes it to make antibodies and to replicate. As long as antigen is being found, the B cells will be told by the T cells and macrophages to make antibodies. Or is it the T helper cells that do this? Any way the replicators get busy and the B cells get busy, flooding the blood plasma with antibody chemicals that attach to the antigenic gluten protein. Since gluten consumes the antibodies, they have to be replaced when more gluten comes along. Fuzzy Logic Well, B cell replication is designed to not be perfect. The mechanisms that transcribe the DNA/RNA stretches that encode antibody peptide sequences have a built in randomizer that will occasionally substitute a different amino acid into the sequence than was in the original. This apparently serves the purpose of making the immune system more adaptable in case the original match was not quite perfect. And if the new antibody shapes don't match anything, they are never activated to make antibodies, and do not replicate further. So under a continuous attack from an antigen, such as gluten, the production of antibodies is always running, perhaps even in high gear. And along with this high rate of activity comes continual varying of the antibody patterns. Unfortunately, many people have self-identification cell surface marker peptides that bear a strong resemblance to gluten protein pieces. So when the random variations in antibody shapes just happen to match fairly closely with one of these usually protective Human Leukocyte Antigens (HLA), the particular type of tissue in the human organism that bears that particular variation of HLA is suddenly treated as a bad guy, as INVADER, instead of SELF. And bang! There goes the thyroid producing cells. Or the Islets of Langerhans insulin producing cells. Or any one of a whole lot of other tissue types. Endomysial tissue, a connective fibrous material surrounding muscle cells apparently is one of the targets of attack, at least as long as gluten is revving up the B cells. I'm not sure what the difference between this sort of attack that only goes on as long as gluten is being consumed and the thyroid or insulin cell attacks that seem to continue after gluten is removed. Perhaps endomysial tissue is only in out-of-the-way places that don't typically get visited by T cells or macrophages, and thus only suffer when the antibodies are being produced in large amounts to fight off gluten. That seems reasonable, since the gluten sets things going by showing up at the intestinal inner wall epithelium which is just loaded with lymphocytes to keep the fauna and flora of the inside of the intestine from getting anywhere they shouldn't. And then there is apparently endomysial tissue in the submucosa of the intestine? At any rate, the intestinal villi get destroyed after a long enough time, and since that is where a lot of digestive enzymes are produced, food doesn't get properly digested, and since the surface area is smaller, it doesn't get properly absorbed. So some of these tissue types are continually exposed to lymphocytes, and so cause a sustained attack, while others seem to be typically sheltered, and thus don't sustain antibody production when gluten is absent. And then there is the increased risk of cancer that is associated with untreated CD. Only is a problem when the immune system is churning away. Not when all is quiescent. All of this suggests that many people who never get Celiac Disease are still experiencing varying degrees of intestinal inflammation from the consumption of gluten. And there is a lot known about inflammation and its apparent linkage to heart trouble, arthritis and a whole lot of other disorders. And there are all the autoimmune disorders that seem to be the result of the churning immune system hitting the wrong combination by accident. There is even one website by a gastroenterologist suggesting that it could be sixty percent or more of mankind that experiences this immune response from gluten ingestion. Various theories have been discussed that involved trigger events to start off the attack against self causing an autoimmune disorder. I suspect that that is not necessary, although it could play some role in starting some autoimmune disorders in some people. Apparently H. Pylori bacteria, the stuff of stomach ulcers, carried by the common housefly, can maintain a chronic infection in the stomach that does the same sort of job as gluten in the intestine. At least it maintains a constant inflammatory state, and has an association with stomach cancers. And supposedly there is an immune reaction in some people to bakers yeast. So what to make of all of this? I think that because there is legitimate research published about the increased risk of cancer in untreated Celiac Disease (CD) patients, and that we have, in the US, only identified about three per cent of those that actually have CD, that one could honestly make a statement. about the safety of consuming gluten from wheat, barley or rye. ================================================== =========== STATEMENT "Since the ingestion of gluten from wheat, barley or rye has been demonstrated, through clinical studies with humans, to cause an elevated risk of cancer, gluten from wheat, barley and rye should be declared a CARCINOGENIC SUBSTANCES. To do any less is to doom our children to the lifetime of slow poisoning that most of us have been experiencing." ================================================== =========== ================================================== =========== ================================================== =========== ================================================== =========== ================================================== =========== University of Chicago Hospitals Celiac disease is far more common than thought http://www.uchospitals.edu/news/2003...210-celiac.php Food Allergy & Anaphylaxis Network http://www.foodallergy.org/ PBC Lab - Dr. Gershwin http://internalmedicine.ucdmc.ucdavi...ology/PBC_Lab/ search engine for gluten free friendly inns, bed and breakfasts, and small hotels http://www.1-888-inn-seek.com/GFinns.htm AAAAI - American Academy of Allergy Asthma and Immunology - www.aaaai.org http://www.aaaai.org/ About.com http--www.autoimmunebook.com http://thyroid.about.com/gi/dynamic/...munebook.c om // Acute Inflammation UK BHAM // http://medweb.bham.ac.uk/http/mod/3/1/a/acute.html // adam.com Encyclopedia Disease Reference // http://oso.adam.com/ Adenoviruses http://www.tulane.edu/~dmsander/WWW/...noviruses.html AllRefer Health - 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Peyer's Patches http://www.microscopyu.com/galleries...rspatches.html NLM's Databases and Electronic Information Sources http://www.nlm.nih.gov/databases/databases.html No WorriesT Gluten-Free Bread Mix http://www.noworriesbread.com/ OMIM - CELIAC DISEASE; CD http://www.ncbi.nlm.nih.gov/entrez/d....cgi?id=212750 Pathology Teaching Menu http://medweb.bham.ac.uk/http/depts/.../teachdir.html Peptide bond - Wikipedia http://en.wikipedia.org/wiki/Peptide_bond Periodic table (WebElements) http://www.webelements.com/ Planet Celiac--the gluten free place to be if you have celiac sprue -- recipes, books and more. http://www.planetceliac.com/ PorkBoard http://www.porkboard.org/Home/default.asp PROWL - Amino Acid Properties http://prowl.rockefeller.edu/aainfo/contents.htm PsoriasisNet http://www.skincarephysicians.com/ps...snet/index.htm Science of dieting Slim pickings http://www.nature.com/cgi-taf/DynaPa...28252a_fs.html Seattle Celiac Support Group http://www.seattleceliacs.com/ Seborrheic Dermatitis http://www.aad.org/pamphlets/seborrhe.html Skindex http://www.skindex.com/index.html Society for Mucosal Immunology http://www.socmucimm.org/ Special Communication - March 8, 1995. Treatment Guidelines for Hyperthyroidism and Hypothyroid http://www.ama-assn.org/sci-pubs/jou..._10/sc4291.htm Special Communication - March 8, 1995. Treatment Guidelines for Hyperthyroidism and Hypothyroidism. (c) AMA 1996 http://www.ama-assn.org/sci-pubs/jou..._10/sc4291.htm Specialty Laboratories - clinical reference laboratory contract research organization http://www.specialtylabs.com/ StopAllergy.com Ask an Allergist http://allergist.stopallergy.com/For...lth/Allergist/ Support Groups http://www.whatnowheat.com/Support%20Groups.htm Swedish Medical Center Home http://www.swedish.org/home.asp?Home The American Gastroenterological Association - Clinical Resources (Patient Brochures) http://www.gastro.org/clinicalRes/brochures/ibd.html The American Gastroenterological Association http://www.gastro.org/ The Antibody Resource Page educational http://www.antibodyresource.com/educational.html The Gluten Free Kitchen http://gfkitchen.server101.com/ The gluten free message board http://members2.boardhost.com/gluten...html?999235741 The Great Plains Laboratory, your center of testing and analysis for Autism, Pervasive Developmental Disorder (PDD) http://www.greatplainslaboratory.com/immune.html The Merck Manual http://www.merck.com/pubs/ The National Fibromyalgia Association http://www.fmaware.org/ Thinner - guide to lowcarb weight loss http://www.thinner.com/ ThirdAge - Health Newsletter - Overlooked, Under-Diagnosed Thyroid Disease Poses a Challenge http://www.thirdage.com/news/article...040326-01.html Thyroid Disease Manager, your source on thyroid disease, hyperthyroidism, hypothyroidism, thyroiditis,thyroid cancer http://www.thyroidmanager.org/ Thyroid Disease Symptoms - Hypothyroidism Symptoms http://www.armourthyroid.com/hypothy.../symptoms.html TNFA promoter polymorphism and susceptibility to brucellosis - Clin Exp Immunol, Vol 121, Issue 3, pp. 480-483 (Full Text) http://www.blackwell-synergy.com/lin....01331.x/full/ Two distinct hemolysins in Trichomonas tenax ATCC 30207 - Oral Microbiol Immunol, Vol 15, Issue 6, pp. 355-359 (Abstract) http://www.blackwell-synergy.com/lin...d=bHR8zMK2xU2f USDA NutrientDatabase http://www.nal.usda.gov/fnic/foodcomp/search/ Van's Wheat Free Waffles. http://www.vansintl.com/wheatfree.php VCUendomysiumResident Cases http://www.pathology.vcu.edu/WirSelfInst/muscle.html virus-adeno http://www.stanford.edu/group/virus/adeno/adeno.html Voluntary Recall of Taco Bell Taco Shells containing StarLink Corn http://www.cast-science.org/cast-sci...y/20000925.htm WAFDO http://www.wafdo.org/ WebRing hub http://j.webring.com/hub?ring=celiac Welcome to Medscape http://www.medscape.com/px/urlinfo Welcome to MedWeb http://medweb.bham.ac.uk/ Welcome to the Gluten Intolerance Group of North America http://www.gluten.net/ Welcome to the Incredible Edible Egg Website http://www.aeb.org/ www.patientcenters.com -- Non-Hodgkin's Lymphoma Center -- What are the NHLs http://www.patientcenters.com/lymphoma/news/nhl2.html York Nutritional Laboratories, Inc... Better health begins at home http://www.yorkallergyusa.com/ [Report] Treatment Algorithms 2000(Table of Contents) http://www.the-infoshop.com/study/dc...rithm_toc.html ================================================== =========== |
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What it all does to us.......
What? Wrong place to post this? How many here have IBS? Or similar?
"Sseaott" SseaottATcomcastDOTnet wrote in message ... P L O N K "Laurence" lharris@nwlinkDOTcom wrote in message ... I am Laurence Harris. I live near Seattle, Washington, USA. I have Celiac Disorder, Hashimoto's Thyroiditis, and about five other brushes with autoimmune disorders. I have a BS degree, have read extensively in chemistry, biochemistry, and broad ranging medical research topics. I have been creating software for computers embedded in medical devices. Most recently, software to operate a Left Ventricular Assist Device - a heart pump, which is now successfully operating in at least two humans to good effect. After learning about the various medical problems that are associated with gluten sensitive enteropathy, I saw a real puzzle staring at me. It became a real teaser to me, and the more I learned, the more there seemed to be to chase down. Since I have a lot of time available, I have jumped in with both feet. I have now spent months researching issues regarding how it is that many people get AutoImmune Disorders, including Celiac Disease, Thyroiditis and a whole host of others. The linking of concepts presented here is my own invention, although all the underlying technology is from the credible published technical works of many others. I have relied only on legitimate sources, mostly medical journal articles, although some comes from informational websites put up by various professors at universities. Some of my information has come from years of reading and study, although I have attempted to find current references for most of it since science forges on. I am inserting a huge list of website references at the end of the text. They are the resources I used for most of my studies. Some of the websites allow you to download entire journal articles as PDFs to store on your hard drive. I do that wherever I can, since that works better than viewing them in your browser. Unfortunately they are not grouped by topic, nor are they in any particular order. To use many of them you must open the website and drill down into areas having research papers, journal articles, patient information and so on. There may be a few that require you to register to be able to access the technical content. The basic picture is that many people, more than have celiac disorder, have an immune system that reacts to some parts of the gluten protein in wheat, barley and rye. They interpret the protein as "enemy" - an antigen - just as though it were a bacterium or virus. Since the immune system reacts to foreign objects penetrating the skin, perhaps this explains why. To follow all this you may want to go to some of the websites and read on peptides, immune system, lymphocytes, acute and chronic inflammation. The Immune System The human body has wonderful ways of protecting itself. The system of interacting parts that defends us from invading bacteria, fungi, viruses and other foreign matter is collectively referred to as the "immune system". The tale we are telling here is one not of allergies (IgE antibodies), but one of a different, more insidious kind of immune system activity, (IgA, IgG and IgM antibodies). The immune system includes cells circulating in the blood and lymph and cells in various other places as well. It includes a variety of cell types from those that are self-moving blob-like hunter-killer cells (macrophages) to several kinds of miniature chemical factories with some making destructive toxins and others making specially shaped "antibodies" that match up to and latch onto the fairly unique cell-surface chemicals used by attacking organisms as tools or protective cover. Blood serum, T-cells, B-cells, macrophages, antibodies, bone marrow, spleen, lymphatic system, and various other organs all work together to detect and destroy invasion forces. It has taken many millions of hours of research and study for us to come as far as we have in our understanding of what happens when a bacterium or virus attempts to invade our bodies. And while we have a lot of the picture we are still learning, still searching for missing pieces to this magnificent puzzle. Cells What we do know is that nearly every type of human cell encases fluids in a cell wall made of a smooth, waterproof, very flexible double-layer of loosely coupled rod-like molecules we call a plasma membrane. The cell wall has various special structures embedded in it to transport materials across the barrier. That is how food energy gets in and how waste products get out. Inside each cell are a variety of different structures; some are tiny chemical factories that convert glucose to ready-to-use chemical energy, and use that energy for motion, or to create other special chemicals needed for the cell's operation. Sometimes the chemicals are to sent out into the rest of the human body for use elsewhere. Cell Identity Flags - Friend or Foe? But dotted all around on the outside of this smooth cell wall there are several types of special "identity flags" - specially shaped chemicals that are firmly anchored in the cell wall with a large specially shaped part "waving in the breeze" telling all passing observers who they are - self. It is not really quite that simplistic, but it is actually a combination of several possible types of identity markers that are recognized by cells in the immune system, telling them "Leave me alone! I'm a friend!" And different types of tissue have slightly differently shaped flags, all still self, but not quite all the same. These flags are called Human Leukocyte Antigens (HLA) proteins. Woe be unto cells, like bacteria, who don't know the right combination of markers for "friend" - the immune system learns their surface markers, creates a complimentary shaped pattern and attaches it to special proteins, called antibodies, that hook onto the foes' flags and tell the immune system "This is a bad guy! Let's take them out!" Once a particular immune system cell recognizes an invader it can trigger cells whose job is to make antibodies to reproduce and make lots more of these useful chemicals. Immune Responses Inflammation, created by the fast responders of the immune system, makes the area surrounding a detected invasion become porous, or permeable, so that antibodies and various immune system cells can "get at" the offenders. Even blood vessel walls become rather leaky. This makes surrounding tissues swell and turn red. So the various parts of the immune system work to penetrate or perforate the cell wall of an invading organism and make its insides all leak out. Some immune system cells pick up the antigens and carry them around with them like flags, telling other cells about the invader's identity. Some use the antibody's matching pattern to latch onto the invading cells' surface features (antigens) and get up against them to unleash little vesicles of destructive chemicals. Others engulf an offender and digest it, or at least they carry away indigestible stuff. Picture these blob-like macrophages, fairly big as blood cells go, slipping along in the blood stream and encountering a battle site - they send out an amoeba-like tentacle, a pseudopod, and pull themselves over to a marked offender, then they ooze around it and rejoin on the other side. When it is fully engulfed they release chemicals, right up against the bad cell, similar to chlorine bleach, that chemically take apart the proteins and lipids that make up the invader's structure. Burp. Even the lowly virus has chemical patterns that the immune system uses to identify them. Virus surface coat chemicals are really tools to make the virus stick to the surface of a human cell so they can get inside that cell. And as a virus drills through the human cell wall it leaves behind various parts of its surface coat, sort of embedded in and floating on the human cell wall. These too are sensed by the immune system and used to identify cells that are being taken over by a virus. These human cells then, are mercilessly destroyed. And the methods work. Takes about two weeks for the immune system to detect the invasion, learn the cell-surface markers left by the viruses, make enough antibody factories ( B-Cells and others ), and do the search and destroy job. When it is all done, and the antibody production shuts down, there are extra of these chemical factories circulating in the blood, sort of on standby, in case the same invaders come again. They would be able to attack and destroy them before they ever get a foothold again. That is learned immunity. Immunity Learned immunity is what we try to induce with a vaccine. A vaccine is just a whole lot of these cell surface markers without the offending bacterium or virus still attached, or at least if the cell is still there it has, hopefully, been killed. Seems to work pretty well most of the time. So we make a mixture of water with pieces of surface marker protein in it and inject it into the inside of the body. The immune system sees the invading stuff and sets up new antibody manufacturing to fight it off. Since there are no real invaders, it is easy to clean up the debris, but the result is that the immune system now has standby troops for that particular type of invader. It is much better to learn immunity without having to suffer through a full scale invasion. The Flags are Proteins So the cell surface markers are mostly bits of protein, which are really just interconnected amino acids, which have shapes unique for that kind of organism. Amino acids are some of the basic building blocks of the human body. We get amino acids from eating and digesting meats and plant materials, although some of them can be made by our own cells. Amino acids also serve as a source of food energy when needed. Depending on what order you string the amino acids together, and what other chemical bits you hook onto the chain at various places, the whole thing folds into a three dimensional shape. These proteins are sometimes referred to as "peptides". (A peptide, then is just a piece of protein.) And shape is what is used by antibodies to "recognize" a cell surface marker. Intestinal Tract The intestinal tract has a single cell layer, the epithelium that forms villi - little finger-like projections that are filled with immune system cells - lymphocytes - T cells, B cells, macrophages and so on. Below the epithelium is something called the submucosa. and under all of it, or more properly surrounding all of it is the muscular intestinal wall. When gluten is present in the intestine, these immune system cells react, and cause inflammation. Inflammation makes blood cell walls - epithelial tissue - become leaky so that plasma containing antibodies can get at the invasion more easily, along with lymphocytes. Unfortunately, the epithelial wall of the intestine becomes leakier, too. It is a positive feedback loop with inflammation. And the worse the inflammation, the more of the gluten protein segments can get in while other stuff is getting "out" into the digestive tract. Antibodies Well, one part of the immune response is to turn on the manufacture of antibodies - chemicals that physically fit like hand and glove, or plug and socket - that match up to the antigens. These little chemical factories are in the B cells. And activating a B cell with a matching antibody causes it to make antibodies and to replicate. As long as antigen is being found, the B cells will be told by the T cells and macrophages to make antibodies. Or is it the T helper cells that do this? Any way the replicators get busy and the B cells get busy, flooding the blood plasma with antibody chemicals that attach to the antigenic gluten protein. Since gluten consumes the antibodies, they have to be replaced when more gluten comes along. Fuzzy Logic Well, B cell replication is designed to not be perfect. The mechanisms that transcribe the DNA/RNA stretches that encode antibody peptide sequences have a built in randomizer that will occasionally substitute a different amino acid into the sequence than was in the original. This apparently serves the purpose of making the immune system more adaptable in case the original match was not quite perfect. And if the new antibody shapes don't match anything, they are never activated to make antibodies, and do not replicate further. So under a continuous attack from an antigen, such as gluten, the production of antibodies is always running, perhaps even in high gear. And along with this high rate of activity comes continual varying of the antibody patterns. Unfortunately, many people have self-identification cell surface marker peptides that bear a strong resemblance to gluten protein pieces. So when the random variations in antibody shapes just happen to match fairly closely with one of these usually protective Human Leukocyte Antigens (HLA), the particular type of tissue in the human organism that bears that particular variation of HLA is suddenly treated as a bad guy, as INVADER, instead of SELF. And bang! There goes the thyroid producing cells. Or the Islets of Langerhans insulin producing cells. Or any one of a whole lot of other tissue types. Endomysial tissue, a connective fibrous material surrounding muscle cells apparently is one of the targets of attack, at least as long as gluten is revving up the B cells. I'm not sure what the difference between this sort of attack that only goes on as long as gluten is being consumed and the thyroid or insulin cell attacks that seem to continue after gluten is removed. Perhaps endomysial tissue is only in out-of-the-way places that don't typically get visited by T cells or macrophages, and thus only suffer when the antibodies are being produced in large amounts to fight off gluten. That seems reasonable, since the gluten sets things going by showing up at the intestinal inner wall epithelium which is just loaded with lymphocytes to keep the fauna and flora of the inside of the intestine from getting anywhere they shouldn't. And then there is apparently endomysial tissue in the submucosa of the intestine? At any rate, the intestinal villi get destroyed after a long enough time, and since that is where a lot of digestive enzymes are produced, food doesn't get properly digested, and since the surface area is smaller, it doesn't get properly absorbed. So some of these tissue types are continually exposed to lymphocytes, and so cause a sustained attack, while others seem to be typically sheltered, and thus don't sustain antibody production when gluten is absent. And then there is the increased risk of cancer that is associated with untreated CD. Only is a problem when the immune system is churning away. Not when all is quiescent. All of this suggests that many people who never get Celiac Disease are still experiencing varying degrees of intestinal inflammation from the consumption of gluten. And there is a lot known about inflammation and its apparent linkage to heart trouble, arthritis and a whole lot of other disorders. And there are all the autoimmune disorders that seem to be the result of the churning immune system hitting the wrong combination by accident. There is even one website by a gastroenterologist suggesting that it could be sixty percent or more of mankind that experiences this immune response from gluten ingestion. Various theories have been discussed that involved trigger events to start off the attack against self causing an autoimmune disorder. I suspect that that is not necessary, although it could play some role in starting some autoimmune disorders in some people. Apparently H. Pylori bacteria, the stuff of stomach ulcers, carried by the common housefly, can maintain a chronic infection in the stomach that does the same sort of job as gluten in the intestine. At least it maintains a constant inflammatory state, and has an association with stomach cancers. And supposedly there is an immune reaction in some people to bakers yeast. So what to make of all of this? I think that because there is legitimate research published about the increased risk of cancer in untreated Celiac Disease (CD) patients, and that we have, in the US, only identified about three per cent of those that actually have CD, that one could honestly make a statement. about the safety of consuming gluten from wheat, barley or rye. ================================================== =========== STATEMENT "Since the ingestion of gluten from wheat, barley or rye has been demonstrated, through clinical studies with humans, to cause an elevated risk of cancer, gluten from wheat, barley and rye should be declared a CARCINOGENIC SUBSTANCES. To do any less is to doom our children to the lifetime of slow poisoning that most of us have been experiencing." ================================================== =========== ================================================== =========== ================================================== =========== ================================================== =========== ================================================== =========== University of Chicago Hospitals Celiac disease is far more common than thought http://www.uchospitals.edu/news/2003...210-celiac.php Food Allergy & Anaphylaxis Network http://www.foodallergy.org/ PBC Lab - Dr. Gershwin http://internalmedicine.ucdmc.ucdavi...ology/PBC_Lab/ search engine for gluten free friendly inns, bed and breakfasts, and small hotels http://www.1-888-inn-seek.com/GFinns.htm AAAAI - American Academy of Allergy Asthma and Immunology - www.aaaai.org http://www.aaaai.org/ About.com http--www.autoimmunebook.com http://thyroid.about.com/gi/dynamic/...munebook.c om // Acute Inflammation UK BHAM // http://medweb.bham.ac.uk/http/mod/3/1/a/acute.html // adam.com Encyclopedia Disease Reference // http://oso.adam.com/ Adenoviruses http://www.tulane.edu/~dmsander/WWW/...noviruses.html AllRefer Health - 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DrGreene.com - caring for the next generation http://www.drgreene.com/21_1522.html Celiac Disease -- eCureMe.com http://www.ecureme.com/emyhealth/Ped...ac_Disease.asp Celiac disease and hypoparathyroidism cross-reaction of endomysial antibodies with parathyroid tissue. http://www.pubmedcentral.nih.gov/art...ype=abstrac t Celiac Disease Foundation http://www.celiac.org/ Celiac Disease NDDIC http://digestive.niddk.nih.gov/ddise...liac/index.htm Celiac Disease http://digestive.niddk.nih.gov/ddise...liac/index.htm Celiac Resources for Physicians http://www.uams.edu/celiac/ Celiac Sprue Research Foundation http://www.celiacsprue.org/ Celiac.com (Diagnosis & Treatment of Celiac Disease A Gluten-Free Diet) http://www.celiac.com/cgi-bin/webc.c...37103580146.6d CELLS alive! http://www.cellsalive.com/index.htm Center For Celiac Research http://www.celiaccenter.org/ Center for Science in the Public Interest http://cspinet.org/ ChemQuik® - Free MSDS MSDS Service Mobile MSDS Chemical Inventory AOS http://www.chemquik.com/site/cq/welcome.asp Chronic inflammatory cells http://medweb.bham.ac.uk/http/depts/...F/infcell.html Clan Thompson's Celiac Site http://www.clanthompson.com/index.php3 Clinical Immunology Society http://www.clinimmsoc.org/ Clonal Selection http://users.rcn.com/jkimball.ma.ult...Selection.html coeliac disease-gluten free info & message board (mainly UK) http://coeliac.info/ Delphi Celiac Disease On-Line Support Group http://forums.delphiforums.com/n/mai...li ac%2Fstart Detecting Celiac Disease in Your Patients - March 1, 1998 - American Academy of Family Physicians http://www.aafp.org/afp/980301ap/pruessn.html Diabetes Care The High Prevalence of Autoantibodies to Tissue Transglutaminase in First-Degree Relatives http://www.findarticles.com/cf_dls/m.../article.jhtml Dietary Soluble Fiber Resource http://www.gy.com/index.htm Digestion and Balance http://www.medhelp.org/forums/gastro...es/35622a.html Electronic Code of Federal Regulations http://ecfr.gpoaccess.gov/ EnteroLab http://www.enterolab.com/ Entrez-PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi eosinophils http://www.nursing.ucla.edu/userpage...c/eosinoph.htm FDA-CFSAN Food Labeling Overview http://www.cfsan.fda.gov/label.html FDA-CFSAN Information about Food Allergies http://vm.cfsan.fda.gov/~dms/wh-alrgy.html Food and Drug Administration Home Page http://www.fda.gov/ Food Safety and Inspection Service Home Page http://www.fsis.usda.gov/ foodallergynetwork.com http://foodallergynetwork.com/ FoodNet (CDC) http://www.cdc.gov/foodnet/ Gastroenterology http://www2.gastrojournal.org/script...r=home&id=gast Gluten Free Brewing Project http://www.fortunecity.com/boozers/b...eer/gfbeer.htm Gluten Free Medications http://www.glutenfreedrugs.com/ Gluten Intolerance Group of North America http://www.gluten.net/ Gluten-Free Trading Company Home Page http://www.gluten-free.tc/ Glycogen Metabolism http://www.indstate.edu/thcme/mwking/glycogen.html GMA, Food Allergy Alliance Develop Easy to Understand Labeling Guidelines GMA News Release 5-31-01 http://www.gmabrands.com/news/docs/N...cfm?DocID=767& Google Search r-s medical http://www.google.com/search?hl=en&i...&q=r-s+medical Grain Inspection http://www.usda.gov/gipsa/ GrainPuritySampling http://www.usda.gov/gipsa/biotech/sample2.htm GSDL Instestinal Permeability Assessment Application Guide http://www.gsdl.com/assessments/ip/appguide/ Guar, Food Resource [http--food.oregonstate.edu-], Oregon State University, Corvallis, OR http://food.oregonstate.edu/gums/guar.html Gum Arabic, Food Resource [http--food.oregonstate.edu-], Oregon State University, Corvallis, OR http://food.oregonstate.edu/gums/arabic.html HealthScout http://www.healthscout.com/ Hospital Practice Recognizing Thyrotoxicosis http://www.hosppract.com/issues/1999/05/dmmmazz.htm How Antibodies are Produced http://www.cellsalive.com/antibody.htm http--www.cvm.okstate.edu-instruction-kocan-vpar5333-5333iid.htm http://www.cvm.okstate.edu/instructi...33/5333iid.htm http--www.inel.gov-x-web-other-framed.shtmlhttp--www.sisweb.com http://www.inel.gov/x-web/other/fram...www.sisweb.com http--www.nal.usda.gov-fnic-foodcomp-search- http://www.nal.usda.gov/fnic/foodcomp/search/ http--www.whatnowheat.com- http://www.whatnowheat.com/ Hypothyroidism and the TSH Reference Range - Alt.Support.Thyroid Newsgroup Website http://www.altsupportthyroid.org/tsh/tshmedrefs1.php IBM Life Sciences Web Lecture Series http://www.ibmweblectureservices.iho...rigin=103ALE3S IMMUNE DEFICIENCY FOUNDATION http://www.primaryimmune.org/ Immune Recognition of the Mycobacterial Cell Wall http://www.eurekah.com/abstract.php?...id=69&catid=73 Immune Tolerance Network - Industry Partnerships http://www.immunetolerance.org/industry/ Immune Tolerance Network http://www.immunetolerance.org/ Immune Web -- Support and Information Network http://www.immuneweb.org/ Immunology of Diabetes Society Home Page http://www.idsoc.org/ IMMUNOSCIENCES LAB. http://www.immuno-sci-lab.com/2003_cat_page64.htm Inflammation Long-Term Effects, from Arthritis.com http://www.arthritis.com/1_5.asp Inflammation Research Association http://www.inflammationresearch.org/ Inflammation The Battle Within http://arthritis.about.com/cs/arthge...flammation.htm Inflammation, Heart Disease and Stroke The Role of C-Reactive Protein http://www.americanheart.org/present...dentifier=4648 INFOMED ONLINE http://www.infomed.org/ International Society for Mountain Medicine http://www.ismmed.org/ Is Subclinical Gluten Intolerance-Celiac Disease Sabotaging Your Health - Thyroid Disease Information http://www.thyroid-info.com/articles/glutenceliac.htm Kaili's Kitchen http://www.wheatlessinseattle.com/ Kimball's Biology Pages http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/ Lab Tests Online Welcome! http://www.labtestsonline.org/ LAMISIL - Nail fungus treatment, tips for healthy nails http://www.lamisil.com/index.jsp?checked=y Legacy Laboratory Services - Legacy Health System - Portland, OR http://www.legacyhealth.org/healthca...php?testid=387 Lipids Online - Educational Resources in Atherosclerosis and Coronary Heart Disease http://www.lipidsonline.org/ Low Carb Research, Atkins Diet Research, Low Carb Diet Research http://www.lowcarbresearch.org/lcr/results.asp LOW CARBOHYDRATE RECIPES http://www.carb-lite.au.com/fdbreakfast.html Lymphoma Patients Information Resources http://www.lymphoma.org.uk/support/i...on/Default.htm Lymphoma Research Foundation Learning About Lymphoma http://www.lymphoma.org/site/PageSer...ename=learning Lymphoma Research Foundation http://www.lymphoma.org/site/PageSer...gename=Seattle Macular Pucker http://www.vrmny.com/ERM.htm Making Your Voice Heard at FDA How to Comment on Proposed Regulations and Submit Petitions http://www.fda.gov/opacom/backgrounders/voice.html MayoClinic.com - Medical and health information for a healthier life from Mayo Clinic http://www.mayoclinic.com/invoke.cfm?id=DS00319 MDDI http://www.devicelink.com/mddi/ MedicineNetInformation on Celiac disease http://www.medicinenet.com/Celiac_Disease/article.htm MedlinePlus Celiac Disease http://www.nlm.nih.gov/medlineplus/celiacdisease.html MEDLINEplus Health Information from the National Library of Medicine http://www.nlm.nih.gov/medlineplus/medlineplus.html MedlinePlus Medical Encyclopedia Autoimmune disorders http://www.nlm.nih.gov/medlineplus/e...cle/000816.htm Metabolic Pathways of Biochemistry http://www.gwu.edu/~mpb/ Molecular Immunology http://www.mi.interhealth.info/ Monterey Bay Aquarium Seafood Watch Program - Regional Seafood Watch Cards http://www.mbayaq.org/cr/cr_seafoodw...w_regional.asp Muscle Biopsy http://www.neuro.wustl.edu/neuromusc...ab/mbiopsy.htm National Institute of Allergy and Infectious Diseases Home Page (NIAID), National Institutes of Health http://www.niaid.nih.gov/default.htm National Institute of Neurological Disorders and Stroke (NINDS) http://www.ninds.nih.gov/ National Institute of Standards and Technology http://nist.gov/ National Pork Producers Council http://www.nppc.org/ Neuromuscular Muscle Autoantibodies http://www.neuro.wustl.edu/neuromusc...mantibody.html NIAID Links to Other Sites http://www.niaid.nih.gov/information/externallinks.htm Nikon MicroscopyU Confocal Image Gallery - Peyer's Patches http://www.microscopyu.com/galleries...rspatches.html NLM's Databases and Electronic Information Sources http://www.nlm.nih.gov/databases/databases.html No WorriesT Gluten-Free Bread Mix http://www.noworriesbread.com/ OMIM - CELIAC DISEASE; CD http://www.ncbi.nlm.nih.gov/entrez/d....cgi?id=212750 Pathology Teaching Menu http://medweb.bham.ac.uk/http/depts/.../teachdir.html Peptide bond - Wikipedia http://en.wikipedia.org/wiki/Peptide_bond Periodic table (WebElements) http://www.webelements.com/ Planet Celiac--the gluten free place to be if you have celiac sprue -- recipes, books and more. http://www.planetceliac.com/ PorkBoard http://www.porkboard.org/Home/default.asp PROWL - Amino Acid Properties http://prowl.rockefeller.edu/aainfo/contents.htm PsoriasisNet http://www.skincarephysicians.com/ps...snet/index.htm Science of dieting Slim pickings http://www.nature.com/cgi-taf/DynaPa...28252a_fs.html Seattle Celiac Support Group http://www.seattleceliacs.com/ Seborrheic Dermatitis http://www.aad.org/pamphlets/seborrhe.html Skindex http://www.skindex.com/index.html Society for Mucosal Immunology http://www.socmucimm.org/ Special Communication - March 8, 1995. Treatment Guidelines for Hyperthyroidism and Hypothyroid http://www.ama-assn.org/sci-pubs/jou..._10/sc4291.htm Special Communication - March 8, 1995. Treatment Guidelines for Hyperthyroidism and Hypothyroidism. (c) AMA 1996 http://www.ama-assn.org/sci-pubs/jou..._10/sc4291.htm Specialty Laboratories - clinical reference laboratory contract research organization http://www.specialtylabs.com/ StopAllergy.com Ask an Allergist http://allergist.stopallergy.com/For...lth/Allergist/ Support Groups http://www.whatnowheat.com/Support%20Groups.htm Swedish Medical Center Home http://www.swedish.org/home.asp?Home The American Gastroenterological Association - Clinical Resources (Patient Brochures) http://www.gastro.org/clinicalRes/brochures/ibd.html The American Gastroenterological Association http://www.gastro.org/ The Antibody Resource Page educational http://www.antibodyresource.com/educational.html The Gluten Free Kitchen http://gfkitchen.server101.com/ The gluten free message board http://members2.boardhost.com/gluten...html?999235741 The Great Plains Laboratory, your center of testing and analysis for Autism, Pervasive Developmental Disorder (PDD) http://www.greatplainslaboratory.com/immune.html The Merck Manual http://www.merck.com/pubs/ The National Fibromyalgia Association http://www.fmaware.org/ Thinner - guide to lowcarb weight loss http://www.thinner.com/ ThirdAge - Health Newsletter - Overlooked, Under-Diagnosed Thyroid Disease Poses a Challenge http://www.thirdage.com/news/article...040326-01.html Thyroid Disease Manager, your source on thyroid disease, hyperthyroidism, hypothyroidism, thyroiditis,thyroid cancer http://www.thyroidmanager.org/ Thyroid Disease Symptoms - Hypothyroidism Symptoms http://www.armourthyroid.com/hypothy.../symptoms.html TNFA promoter polymorphism and susceptibility to brucellosis - Clin Exp Immunol, Vol 121, Issue 3, pp. 480-483 (Full Text) http://www.blackwell-synergy.com/lin....01331.x/full/ Two distinct hemolysins in Trichomonas tenax ATCC 30207 - Oral Microbiol Immunol, Vol 15, Issue 6, pp. 355-359 (Abstract) http://www.blackwell-synergy.com/lin...d=bHR8zMK2xU2f USDA NutrientDatabase http://www.nal.usda.gov/fnic/foodcomp/search/ Van's Wheat Free Waffles. http://www.vansintl.com/wheatfree.php VCUendomysiumResident Cases http://www.pathology.vcu.edu/WirSelfInst/muscle.html virus-adeno http://www.stanford.edu/group/virus/adeno/adeno.html Voluntary Recall of Taco Bell Taco Shells containing StarLink Corn http://www.cast-science.org/cast-sci...y/20000925.htm WAFDO http://www.wafdo.org/ WebRing hub http://j.webring.com/hub?ring=celiac Welcome to Medscape http://www.medscape.com/px/urlinfo Welcome to MedWeb http://medweb.bham.ac.uk/ Welcome to the Gluten Intolerance Group of North America http://www.gluten.net/ Welcome to the Incredible Edible Egg Website http://www.aeb.org/ www.patientcenters.com -- Non-Hodgkin's Lymphoma Center -- What are the NHLs http://www.patientcenters.com/lymphoma/news/nhl2.html York Nutritional Laboratories, Inc... Better health begins at home http://www.yorkallergyusa.com/ [Report] Treatment Algorithms 2000(Table of Contents) http://www.the-infoshop.com/study/dc...rithm_toc.html ================================================== =========== |
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Laurence wrote:
What? Wrong place to post this? How many here have IBS? Or similar? Personally, I would ignore the first response you received. I'll take the time to read and understand what you have posted and the assertions contained therein. I'm kind of looking forward to the meaningful responses you might get from others on this write-up. -- JJ. |
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Laurence wrote:
What? Wrong place to post this? How many here have IBS? Or similar? Don't worry about him Laurence, he's just a kid and a twit to boot. He "plonks" everyone he doesn't agree with or likes. I've heard of a few people who have IBS around here. Monica -- Started 01/20/04 362/322.4/250 __________________________________________________ ______ "Watch what people are cynical about, and one can often discover what they lack. - Harry Emerson Fosdick --- Outgoing mail is certified Virus Free. Checked by AVG anti-virus system (http://www.grisoft.com). Version: 6.0.644 / Virus Database: 412 - Release Date: 3/26/04 |
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"Sseaott" SseaottATcomcastDOTnet wrote in message ... P L O N K So, why not snip the OP's 35kb of drivel, rather than steal bandwidth by repeating it? Sheesh! |
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I'm a kid?
Nice to know you know who I am when you don't know me lol. This is a newsgroup about carbs, NOT IMBS! ONCE AGAIN P L O N K ! "TavliGal" wrote in message news:7labc.10560$oR5.813@pd7tw3no... Laurence wrote: What? Wrong place to post this? How many here have IBS? Or similar? Don't worry about him Laurence, he's just a kid and a twit to boot. He "plonks" everyone he doesn't agree with or likes. I've heard of a few people who have IBS around here. Monica -- Started 01/20/04 362/322.4/250 __________________________________________________ ______ "Watch what people are cynical about, and one can often discover what they lack. - Harry Emerson Fosdick --- Outgoing mail is certified Virus Free. Checked by AVG anti-virus system (http://www.grisoft.com). Version: 6.0.644 / Virus Database: 412 - Release Date: 3/26/04 |
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Personally, if I were you, which I'm not, THANK GOD!...I would go order a
Pizza... P L O N K ! "JJ" wrote in message news:Qiabc.58812$w54.368475@attbi_s01... Laurence wrote: What? Wrong place to post this? How many here have IBS? Or similar? Personally, I would ignore the first response you received. I'll take the time to read and understand what you have posted and the assertions contained therein. I'm kind of looking forward to the meaningful responses you might get from others on this write-up. -- JJ. |
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This is a newsgroup about LOW CARBS, NOT IBS!
Now go on you troll, find your way home. "Laurence" lharris@nwlinkDOTcom wrote in message ... What? Wrong place to post this? How many here have IBS? Or similar? "Sseaott" SseaottATcomcastDOTnet wrote in message ... P L O N K "Laurence" lharris@nwlinkDOTcom wrote in message ... I am Laurence Harris. I live near Seattle, Washington, USA. I have Celiac Disorder, Hashimoto's Thyroiditis, and about five other brushes with autoimmune disorders. I have a BS degree, have read extensively in chemistry, biochemistry, and broad ranging medical research topics. I have been creating software for computers embedded in medical devices. Most recently, software to operate a Left Ventricular Assist Device - a heart pump, which is now successfully operating in at least two humans to good effect. After learning about the various medical problems that are associated with gluten sensitive enteropathy, I saw a real puzzle staring at me. It became a real teaser to me, and the more I learned, the more there seemed to be to chase down. Since I have a lot of time available, I have jumped in with both feet. I have now spent months researching issues regarding how it is that many people get AutoImmune Disorders, including Celiac Disease, Thyroiditis and a whole host of others. The linking of concepts presented here is my own invention, although all the underlying technology is from the credible published technical works of many others. I have relied only on legitimate sources, mostly medical journal articles, although some comes from informational websites put up by various professors at universities. Some of my information has come from years of reading and study, although I have attempted to find current references for most of it since science forges on. I am inserting a huge list of website references at the end of the text. They are the resources I used for most of my studies. Some of the websites allow you to download entire journal articles as PDFs to store on your hard drive. I do that wherever I can, since that works better than viewing them in your browser. Unfortunately they are not grouped by topic, nor are they in any particular order. To use many of them you must open the website and drill down into areas having research papers, journal articles, patient information and so on. There may be a few that require you to register to be able to access the technical content. The basic picture is that many people, more than have celiac disorder, have an immune system that reacts to some parts of the gluten protein in wheat, barley and rye. They interpret the protein as "enemy" - an antigen - just as though it were a bacterium or virus. Since the immune system reacts to foreign objects penetrating the skin, perhaps this explains why. To follow all this you may want to go to some of the websites and read on peptides, immune system, lymphocytes, acute and chronic inflammation. The Immune System The human body has wonderful ways of protecting itself. The system of interacting parts that defends us from invading bacteria, fungi, viruses and other foreign matter is collectively referred to as the "immune system". The tale we are telling here is one not of allergies (IgE antibodies), but one of a different, more insidious kind of immune system activity, (IgA, IgG and IgM antibodies). The immune system includes cells circulating in the blood and lymph and cells in various other places as well. It includes a variety of cell types from those that are self-moving blob-like hunter-killer cells (macrophages) to several kinds of miniature chemical factories with some making destructive toxins and others making specially shaped "antibodies" that match up to and latch onto the fairly unique cell-surface chemicals used by attacking organisms as tools or protective cover. Blood serum, T-cells, B-cells, macrophages, antibodies, bone marrow, spleen, lymphatic system, and various other organs all work together to detect and destroy invasion forces. It has taken many millions of hours of research and study for us to come as far as we have in our understanding of what happens when a bacterium or virus attempts to invade our bodies. And while we have a lot of the picture we are still learning, still searching for missing pieces to this magnificent puzzle. Cells What we do know is that nearly every type of human cell encases fluids in a cell wall made of a smooth, waterproof, very flexible double-layer of loosely coupled rod-like molecules we call a plasma membrane. The cell wall has various special structures embedded in it to transport materials across the barrier. That is how food energy gets in and how waste products get out. Inside each cell are a variety of different structures; some are tiny chemical factories that convert glucose to ready-to-use chemical energy, and use that energy for motion, or to create other special chemicals needed for the cell's operation. Sometimes the chemicals are to sent out into the rest of the human body for use elsewhere. Cell Identity Flags - Friend or Foe? But dotted all around on the outside of this smooth cell wall there are several types of special "identity flags" - specially shaped chemicals that are firmly anchored in the cell wall with a large specially shaped part "waving in the breeze" telling all passing observers who they are - self. It is not really quite that simplistic, but it is actually a combination of several possible types of identity markers that are recognized by cells in the immune system, telling them "Leave me alone! I'm a friend!" And different types of tissue have slightly differently shaped flags, all still self, but not quite all the same. These flags are called Human Leukocyte Antigens (HLA) proteins. Woe be unto cells, like bacteria, who don't know the right combination of markers for "friend" - the immune system learns their surface markers, creates a complimentary shaped pattern and attaches it to special proteins, called antibodies, that hook onto the foes' flags and tell the immune system "This is a bad guy! Let's take them out!" Once a particular immune system cell recognizes an invader it can trigger cells whose job is to make antibodies to reproduce and make lots more of these useful chemicals. Immune Responses Inflammation, created by the fast responders of the immune system, makes the area surrounding a detected invasion become porous, or permeable, so that antibodies and various immune system cells can "get at" the offenders. Even blood vessel walls become rather leaky. This makes surrounding tissues swell and turn red. So the various parts of the immune system work to penetrate or perforate the cell wall of an invading organism and make its insides all leak out. Some immune system cells pick up the antigens and carry them around with them like flags, telling other cells about the invader's identity. Some use the antibody's matching pattern to latch onto the invading cells' surface features (antigens) and get up against them to unleash little vesicles of destructive chemicals. Others engulf an offender and digest it, or at least they carry away indigestible stuff. Picture these blob-like macrophages, fairly big as blood cells go, slipping along in the blood stream and encountering a battle site - they send out an amoeba-like tentacle, a pseudopod, and pull themselves over to a marked offender, then they ooze around it and rejoin on the other side. When it is fully engulfed they release chemicals, right up against the bad cell, similar to chlorine bleach, that chemically take apart the proteins and lipids that make up the invader's structure. Burp. Even the lowly virus has chemical patterns that the immune system uses to identify them. Virus surface coat chemicals are really tools to make the virus stick to the surface of a human cell so they can get inside that cell. And as a virus drills through the human cell wall it leaves behind various parts of its surface coat, sort of embedded in and floating on the human cell wall. These too are sensed by the immune system and used to identify cells that are being taken over by a virus. These human cells then, are mercilessly destroyed. And the methods work. Takes about two weeks for the immune system to detect the invasion, learn the cell-surface markers left by the viruses, make enough antibody factories ( B-Cells and others ), and do the search and destroy job. When it is all done, and the antibody production shuts down, there are extra of these chemical factories circulating in the blood, sort of on standby, in case the same invaders come again. They would be able to attack and destroy them before they ever get a foothold again. That is learned immunity. Immunity Learned immunity is what we try to induce with a vaccine. A vaccine is just a whole lot of these cell surface markers without the offending bacterium or virus still attached, or at least if the cell is still there it has, hopefully, been killed. Seems to work pretty well most of the time. So we make a mixture of water with pieces of surface marker protein in it and inject it into the inside of the body. The immune system sees the invading stuff and sets up new antibody manufacturing to fight it off. Since there are no real invaders, it is easy to clean up the debris, but the result is that the immune system now has standby troops for that particular type of invader. It is much better to learn immunity without having to suffer through a full scale invasion. The Flags are Proteins So the cell surface markers are mostly bits of protein, which are really just interconnected amino acids, which have shapes unique for that kind of organism. Amino acids are some of the basic building blocks of the human body. We get amino acids from eating and digesting meats and plant materials, although some of them can be made by our own cells. Amino acids also serve as a source of food energy when needed. Depending on what order you string the amino acids together, and what other chemical bits you hook onto the chain at various places, the whole thing folds into a three dimensional shape. These proteins are sometimes referred to as "peptides". (A peptide, then is just a piece of protein.) And shape is what is used by antibodies to "recognize" a cell surface marker. Intestinal Tract The intestinal tract has a single cell layer, the epithelium that forms villi - little finger-like projections that are filled with immune system cells - lymphocytes - T cells, B cells, macrophages and so on. Below the epithelium is something called the submucosa. and under all of it, or more properly surrounding all of it is the muscular intestinal wall. When gluten is present in the intestine, these immune system cells react, and cause inflammation. Inflammation makes blood cell walls - epithelial tissue - become leaky so that plasma containing antibodies can get at the invasion more easily, along with lymphocytes. Unfortunately, the epithelial wall of the intestine becomes leakier, too. It is a positive feedback loop with inflammation. And the worse the inflammation, the more of the gluten protein segments can get in while other stuff is getting "out" into the digestive tract. Antibodies Well, one part of the immune response is to turn on the manufacture of antibodies - chemicals that physically fit like hand and glove, or plug and socket - that match up to the antigens. These little chemical factories are in the B cells. And activating a B cell with a matching antibody causes it to make antibodies and to replicate. As long as antigen is being found, the B cells will be told by the T cells and macrophages to make antibodies. Or is it the T helper cells that do this? Any way the replicators get busy and the B cells get busy, flooding the blood plasma with antibody chemicals that attach to the antigenic gluten protein. Since gluten consumes the antibodies, they have to be replaced when more gluten comes along. Fuzzy Logic Well, B cell replication is designed to not be perfect. The mechanisms that transcribe the DNA/RNA stretches that encode antibody peptide sequences have a built in randomizer that will occasionally substitute a different amino acid into the sequence than was in the original. This apparently serves the purpose of making the immune system more adaptable in case the original match was not quite perfect. And if the new antibody shapes don't match anything, they are never activated to make antibodies, and do not replicate further. So under a continuous attack from an antigen, such as gluten, the production of antibodies is always running, perhaps even in high gear. And along with this high rate of activity comes continual varying of the antibody patterns. Unfortunately, many people have self-identification cell surface marker peptides that bear a strong resemblance to gluten protein pieces. So when the random variations in antibody shapes just happen to match fairly closely with one of these usually protective Human Leukocyte Antigens (HLA), the particular type of tissue in the human organism that bears that particular variation of HLA is suddenly treated as a bad guy, as INVADER, instead of SELF. And bang! There goes the thyroid producing cells. Or the Islets of Langerhans insulin producing cells. Or any one of a whole lot of other tissue types. Endomysial tissue, a connective fibrous material surrounding muscle cells apparently is one of the targets of attack, at least as long as gluten is revving up the B cells. I'm not sure what the difference between this sort of attack that only goes on as long as gluten is being consumed and the thyroid or insulin cell attacks that seem to continue after gluten is removed. Perhaps endomysial tissue is only in out-of-the-way places that don't typically get visited by T cells or macrophages, and thus only suffer when the antibodies are being produced in large amounts to fight off gluten. That seems reasonable, since the gluten sets things going by showing up at the intestinal inner wall epithelium which is just loaded with lymphocytes to keep the fauna and flora of the inside of the intestine from getting anywhere they shouldn't. And then there is apparently endomysial tissue in the submucosa of the intestine? At any rate, the intestinal villi get destroyed after a long enough time, and since that is where a lot of digestive enzymes are produced, food doesn't get properly digested, and since the surface area is smaller, it doesn't get properly absorbed. So some of these tissue types are continually exposed to lymphocytes, and so cause a sustained attack, while others seem to be typically sheltered, and thus don't sustain antibody production when gluten is absent. And then there is the increased risk of cancer that is associated with untreated CD. Only is a problem when the immune system is churning away. Not when all is quiescent. All of this suggests that many people who never get Celiac Disease are still experiencing varying degrees of intestinal inflammation from the consumption of gluten. And there is a lot known about inflammation and its apparent linkage to heart trouble, arthritis and a whole lot of other disorders. And there are all the autoimmune disorders that seem to be the result of the churning immune system hitting the wrong combination by accident. There is even one website by a gastroenterologist suggesting that it could be sixty percent or more of mankind that experiences this immune response from gluten ingestion. Various theories have been discussed that involved trigger events to start off the attack against self causing an autoimmune disorder. I suspect that that is not necessary, although it could play some role in starting some autoimmune disorders in some people. Apparently H. Pylori bacteria, the stuff of stomach ulcers, carried by the common housefly, can maintain a chronic infection in the stomach that does the same sort of job as gluten in the intestine. At least it maintains a constant inflammatory state, and has an association with stomach cancers. And supposedly there is an immune reaction in some people to bakers yeast. So what to make of all of this? I think that because there is legitimate research published about the increased risk of cancer in untreated Celiac Disease (CD) patients, and that we have, in the US, only identified about three per cent of those that actually have CD, that one could honestly make a statement. about the safety of consuming gluten from wheat, barley or rye. ================================================== =========== STATEMENT "Since the ingestion of gluten from wheat, barley or rye has been demonstrated, through clinical studies with humans, to cause an elevated risk of cancer, gluten from wheat, barley and rye should be declared a CARCINOGENIC SUBSTANCES. To do any less is to doom our children to the lifetime of slow poisoning that most of us have been experiencing." ================================================== =========== ================================================== =========== ================================================== =========== ================================================== =========== ================================================== =========== University of Chicago Hospitals Celiac disease is far more common than thought http://www.uchospitals.edu/news/2003...210-celiac.php Food Allergy & Anaphylaxis Network http://www.foodallergy.org/ PBC Lab - Dr. Gershwin http://internalmedicine.ucdmc.ucdavi...ology/PBC_Lab/ search engine for gluten free friendly inns, bed and breakfasts, and small hotels http://www.1-888-inn-seek.com/GFinns.htm AAAAI - American Academy of Allergy Asthma and Immunology - www.aaaai.org http://www.aaaai.org/ About.com http--www.autoimmunebook.com http://thyroid.about.com/gi/dynamic/...munebook.c om // Acute Inflammation UK BHAM // http://medweb.bham.ac.uk/http/mod/3/1/a/acute.html // adam.com Encyclopedia Disease Reference // http://oso.adam.com/ Adenoviruses http://www.tulane.edu/~dmsander/WWW/...noviruses.html AllRefer Health - Autoimmune Disorders http://health.allrefer.com/health/au...ders-info.html AllRefer Health - Celiac Disease - Sprue Support Groups http://health.allrefer.com/health/ce...e-support.html Alt.Support.Thyroid Newsgroup Website http://www.altsupportthyroid.org/ American Academy of Dermatology http://www.aad.org/ American Academy of Dermatology http://www.skincarephysicians.com/eczemanet/whatIs.html American Association of Immunologists http://www.aai.org/ American Association of Immunologists Journal http://www.jimmunol.org/ American Peptide Society http://www.ampepsoc.org/ American Pharmaceutical Online References http://www.medicalresourcesusa.com/pharmrefguide.htm American Thyroid Association http://www.thyroid.org/ Antigen Receptor Diversity http://users.rcn.com/jkimball.ma.ult...Diversity.html Applied Biosystems http://www.appliedbiosystems.com/ Archives of http://maelstrom.stjohns.edu/archives/celiac.html Aspiration Biopsy of the Thyroid http://www.thyroidfoundation.org/aspiration.htm Asthma and Allergy Information and Research (AAIR) Home Page http://www.users.globalnet.co.uk/~aair/ Atkins Diet & Low Carbohydrate Weight-Loss Support - Low Carb Diet Recipes & Resources http://www.lowcarb.ca/ Atkins Nutritionals Home http://atkinscenter.com/dev/ AuthenticFoods http://www.authenticfoods.com/ Autoimmune Disorders http://www.thedoctorsdoctor.com/dise..._disorders.htm Autoimmunity AARDA American Autoimmune Related Diseases Association http://www.aarda.org/ B Cells and T Cells http://users.rcn.com/jkimball.ma.ult...nd_Tcells.html BBC - Science & Nature - Horizon - The Atkins Diet http://www.bbc.co.uk/science/horizon...instrans.shtml Canadian Celiac Association http://www.celiac.ca/englishcca.html Candida, Fibromyalgia, IBS, Celiac, Colitis, yeast infections, thrush, sinusitis, leaky gut syndrome,etc http://www.candidafree.net/pages/1/index.htm Candida http://www.candidafree.net/pages/1/index.htm Carrageenan, Food Resource [http--food.oregonstate.edu-], Oregon State University, Corvallis, OR http://food.oregonstate.edu/gums/carr.html Case Study A 37-Year-Old Man With Type 1 Diabetes, Vomiting, and Diarrhea http://journal.diabetes.org/clinical...1999/pg188.htm CDC Health Topic Foodborne Illnesses http://www.cdc.gov/health/foodill.htm CELIAC (Celiac-Coeliac Wheat-Gluten-Free List) http://www.enabling.org/ia/celiac/ Celiac Disease - DrGreene.com - caring for the next generation http://www.drgreene.com/21_1522.html Celiac Disease -- eCureMe.com http://www.ecureme.com/emyhealth/Ped...ac_Disease.asp Celiac disease and hypoparathyroidism cross-reaction of endomysial antibodies with parathyroid tissue. http://www.pubmedcentral.nih.gov/art...ype=abstrac t Celiac Disease Foundation http://www.celiac.org/ Celiac Disease NDDIC http://digestive.niddk.nih.gov/ddise...liac/index.htm Celiac Disease http://digestive.niddk.nih.gov/ddise...liac/index.htm Celiac Resources for Physicians http://www.uams.edu/celiac/ Celiac Sprue Research Foundation http://www.celiacsprue.org/ Celiac.com (Diagnosis & Treatment of Celiac Disease A Gluten-Free Diet) http://www.celiac.com/cgi-bin/webc.c...37103580146.6d CELLS alive! http://www.cellsalive.com/index.htm Center For Celiac Research http://www.celiaccenter.org/ Center for Science in the Public Interest http://cspinet.org/ ChemQuik® - Free MSDS MSDS Service Mobile MSDS Chemical Inventory AOS http://www.chemquik.com/site/cq/welcome.asp Chronic inflammatory cells http://medweb.bham.ac.uk/http/depts/...F/infcell.html Clan Thompson's Celiac Site http://www.clanthompson.com/index.php3 Clinical Immunology Society http://www.clinimmsoc.org/ Clonal Selection http://users.rcn.com/jkimball.ma.ult...Selection.html coeliac disease-gluten free info & message board (mainly UK) http://coeliac.info/ Delphi Celiac Disease On-Line Support Group http://forums.delphiforums.com/n/mai...li ac%2Fstart Detecting Celiac Disease in Your Patients - March 1, 1998 - American Academy of Family Physicians http://www.aafp.org/afp/980301ap/pruessn.html Diabetes Care The High Prevalence of Autoantibodies to Tissue Transglutaminase in First-Degree Relatives http://www.findarticles.com/cf_dls/m.../article.jhtml Dietary Soluble Fiber Resource http://www.gy.com/index.htm Digestion and Balance http://www.medhelp.org/forums/gastro...es/35622a.html Electronic Code of Federal Regulations http://ecfr.gpoaccess.gov/ EnteroLab http://www.enterolab.com/ Entrez-PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi eosinophils http://www.nursing.ucla.edu/userpage...c/eosinoph.htm FDA-CFSAN Food Labeling Overview http://www.cfsan.fda.gov/label.html FDA-CFSAN Information about Food Allergies http://vm.cfsan.fda.gov/~dms/wh-alrgy.html Food and Drug Administration Home Page http://www.fda.gov/ Food Safety and Inspection Service Home Page http://www.fsis.usda.gov/ foodallergynetwork.com http://foodallergynetwork.com/ FoodNet (CDC) http://www.cdc.gov/foodnet/ Gastroenterology http://www2.gastrojournal.org/script...r=home&id=gast Gluten Free Brewing Project http://www.fortunecity.com/boozers/b...eer/gfbeer.htm Gluten Free Medications http://www.glutenfreedrugs.com/ Gluten Intolerance Group of North America http://www.gluten.net/ Gluten-Free Trading Company Home Page http://www.gluten-free.tc/ Glycogen Metabolism http://www.indstate.edu/thcme/mwking/glycogen.html GMA, Food Allergy Alliance Develop Easy to Understand Labeling Guidelines GMA News Release 5-31-01 http://www.gmabrands.com/news/docs/N...cfm?DocID=767& Google Search r-s medical http://www.google.com/search?hl=en&i...&q=r-s+medical Grain Inspection http://www.usda.gov/gipsa/ GrainPuritySampling http://www.usda.gov/gipsa/biotech/sample2.htm GSDL Instestinal Permeability Assessment Application Guide http://www.gsdl.com/assessments/ip/appguide/ Guar, Food Resource [http--food.oregonstate.edu-], Oregon State University, Corvallis, OR http://food.oregonstate.edu/gums/guar.html Gum Arabic, Food Resource [http--food.oregonstate.edu-], Oregon State University, Corvallis, OR http://food.oregonstate.edu/gums/arabic.html HealthScout http://www.healthscout.com/ Hospital Practice Recognizing Thyrotoxicosis http://www.hosppract.com/issues/1999/05/dmmmazz.htm How Antibodies are Produced http://www.cellsalive.com/antibody.htm http--www.cvm.okstate.edu-instruction-kocan-vpar5333-5333iid.htm http://www.cvm.okstate.edu/instructi...33/5333iid.htm http--www.inel.gov-x-web-other-framed.shtmlhttp--www.sisweb.com http://www.inel.gov/x-web/other/fram...www.sisweb.com http--www.nal.usda.gov-fnic-foodcomp-search- http://www.nal.usda.gov/fnic/foodcomp/search/ http--www.whatnowheat.com- http://www.whatnowheat.com/ Hypothyroidism and the TSH Reference Range - Alt.Support.Thyroid Newsgroup Website http://www.altsupportthyroid.org/tsh/tshmedrefs1.php IBM Life Sciences Web Lecture Series http://www.ibmweblectureservices.iho...rigin=103ALE3S IMMUNE DEFICIENCY FOUNDATION http://www.primaryimmune.org/ Immune Recognition of the Mycobacterial Cell Wall http://www.eurekah.com/abstract.php?...id=69&catid=73 Immune Tolerance Network - Industry Partnerships http://www.immunetolerance.org/industry/ Immune Tolerance Network http://www.immunetolerance.org/ Immune Web -- Support and Information Network http://www.immuneweb.org/ Immunology of Diabetes Society Home Page http://www.idsoc.org/ IMMUNOSCIENCES LAB. http://www.immuno-sci-lab.com/2003_cat_page64.htm Inflammation Long-Term Effects, from Arthritis.com http://www.arthritis.com/1_5.asp Inflammation Research Association http://www.inflammationresearch.org/ Inflammation The Battle Within http://arthritis.about.com/cs/arthge...flammation.htm Inflammation, Heart Disease and Stroke The Role of C-Reactive Protein http://www.americanheart.org/present...dentifier=4648 INFOMED ONLINE http://www.infomed.org/ International Society for Mountain Medicine http://www.ismmed.org/ Is Subclinical Gluten Intolerance-Celiac Disease Sabotaging Your Health - Thyroid Disease Information http://www.thyroid-info.com/articles/glutenceliac.htm Kaili's Kitchen http://www.wheatlessinseattle.com/ Kimball's Biology Pages http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/ Lab Tests Online Welcome! http://www.labtestsonline.org/ LAMISIL - Nail fungus treatment, tips for healthy nails http://www.lamisil.com/index.jsp?checked=y Legacy Laboratory Services - Legacy Health System - Portland, OR http://www.legacyhealth.org/healthca...php?testid=387 Lipids Online - Educational Resources in Atherosclerosis and Coronary Heart Disease http://www.lipidsonline.org/ Low Carb Research, Atkins Diet Research, Low Carb Diet Research http://www.lowcarbresearch.org/lcr/results.asp LOW CARBOHYDRATE RECIPES http://www.carb-lite.au.com/fdbreakfast.html Lymphoma Patients Information Resources http://www.lymphoma.org.uk/support/i...on/Default.htm Lymphoma Research Foundation Learning About Lymphoma http://www.lymphoma.org/site/PageSer...ename=learning Lymphoma Research Foundation http://www.lymphoma.org/site/PageSer...gename=Seattle Macular Pucker http://www.vrmny.com/ERM.htm Making Your Voice Heard at FDA How to Comment on Proposed Regulations and Submit Petitions http://www.fda.gov/opacom/backgrounders/voice.html MayoClinic.com - Medical and health information for a healthier life from Mayo Clinic http://www.mayoclinic.com/invoke.cfm?id=DS00319 MDDI http://www.devicelink.com/mddi/ MedicineNetInformation on Celiac disease http://www.medicinenet.com/Celiac_Disease/article.htm MedlinePlus Celiac Disease http://www.nlm.nih.gov/medlineplus/celiacdisease.html MEDLINEplus Health Information from the National Library of Medicine http://www.nlm.nih.gov/medlineplus/medlineplus.html MedlinePlus Medical Encyclopedia Autoimmune disorders http://www.nlm.nih.gov/medlineplus/e...cle/000816.htm Metabolic Pathways of Biochemistry http://www.gwu.edu/~mpb/ Molecular Immunology http://www.mi.interhealth.info/ Monterey Bay Aquarium Seafood Watch Program - Regional Seafood Watch Cards http://www.mbayaq.org/cr/cr_seafoodw...w_regional.asp Muscle Biopsy http://www.neuro.wustl.edu/neuromusc...ab/mbiopsy.htm National Institute of Allergy and Infectious Diseases Home Page (NIAID), National Institutes of Health http://www.niaid.nih.gov/default.htm National Institute of Neurological Disorders and Stroke (NINDS) http://www.ninds.nih.gov/ National Institute of Standards and Technology http://nist.gov/ National Pork Producers Council http://www.nppc.org/ Neuromuscular Muscle Autoantibodies http://www.neuro.wustl.edu/neuromusc...mantibody.html NIAID Links to Other Sites http://www.niaid.nih.gov/information/externallinks.htm Nikon MicroscopyU Confocal Image Gallery - Peyer's Patches http://www.microscopyu.com/galleries...rspatches.html NLM's Databases and Electronic Information Sources http://www.nlm.nih.gov/databases/databases.html No WorriesT Gluten-Free Bread Mix http://www.noworriesbread.com/ OMIM - CELIAC DISEASE; CD http://www.ncbi.nlm.nih.gov/entrez/d....cgi?id=212750 Pathology Teaching Menu http://medweb.bham.ac.uk/http/depts/.../teachdir.html Peptide bond - Wikipedia http://en.wikipedia.org/wiki/Peptide_bond Periodic table (WebElements) http://www.webelements.com/ Planet Celiac--the gluten free place to be if you have celiac sprue -- recipes, books and more. http://www.planetceliac.com/ PorkBoard http://www.porkboard.org/Home/default.asp PROWL - Amino Acid Properties http://prowl.rockefeller.edu/aainfo/contents.htm PsoriasisNet http://www.skincarephysicians.com/ps...snet/index.htm Science of dieting Slim pickings http://www.nature.com/cgi-taf/DynaPa...28252a_fs.html Seattle Celiac Support Group http://www.seattleceliacs.com/ Seborrheic Dermatitis http://www.aad.org/pamphlets/seborrhe.html Skindex http://www.skindex.com/index.html Society for Mucosal Immunology http://www.socmucimm.org/ Special Communication - March 8, 1995. Treatment Guidelines for Hyperthyroidism and Hypothyroid http://www.ama-assn.org/sci-pubs/jou..._10/sc4291.htm Special Communication - March 8, 1995. Treatment Guidelines for Hyperthyroidism and Hypothyroidism. (c) AMA 1996 http://www.ama-assn.org/sci-pubs/jou..._10/sc4291.htm Specialty Laboratories - clinical reference laboratory contract research organization http://www.specialtylabs.com/ StopAllergy.com Ask an Allergist http://allergist.stopallergy.com/For...lth/Allergist/ Support Groups http://www.whatnowheat.com/Support%20Groups.htm Swedish Medical Center Home http://www.swedish.org/home.asp?Home The American Gastroenterological Association - Clinical Resources (Patient Brochures) http://www.gastro.org/clinicalRes/brochures/ibd.html The American Gastroenterological Association http://www.gastro.org/ The Antibody Resource Page educational http://www.antibodyresource.com/educational.html The Gluten Free Kitchen http://gfkitchen.server101.com/ The gluten free message board http://members2.boardhost.com/gluten...html?999235741 The Great Plains Laboratory, your center of testing and analysis for Autism, Pervasive Developmental Disorder (PDD) http://www.greatplainslaboratory.com/immune.html The Merck Manual http://www.merck.com/pubs/ The National Fibromyalgia Association http://www.fmaware.org/ Thinner - guide to lowcarb weight loss http://www.thinner.com/ ThirdAge - Health Newsletter - Overlooked, Under-Diagnosed Thyroid Disease Poses a Challenge http://www.thirdage.com/news/article...040326-01.html Thyroid Disease Manager, your source on thyroid disease, hyperthyroidism, hypothyroidism, thyroiditis,thyroid cancer http://www.thyroidmanager.org/ Thyroid Disease Symptoms - Hypothyroidism Symptoms http://www.armourthyroid.com/hypothy.../symptoms.html TNFA promoter polymorphism and susceptibility to brucellosis - Clin Exp Immunol, Vol 121, Issue 3, pp. 480-483 (Full Text) http://www.blackwell-synergy.com/lin....01331.x/full/ Two distinct hemolysins in Trichomonas tenax ATCC 30207 - Oral Microbiol Immunol, Vol 15, Issue 6, pp. 355-359 (Abstract) http://www.blackwell-synergy.com/lin...d=bHR8zMK2xU2f USDA NutrientDatabase http://www.nal.usda.gov/fnic/foodcomp/search/ Van's Wheat Free Waffles. http://www.vansintl.com/wheatfree.php VCUendomysiumResident Cases http://www.pathology.vcu.edu/WirSelfInst/muscle.html virus-adeno http://www.stanford.edu/group/virus/adeno/adeno.html Voluntary Recall of Taco Bell Taco Shells containing StarLink Corn http://www.cast-science.org/cast-sci...y/20000925.htm WAFDO http://www.wafdo.org/ WebRing hub http://j.webring.com/hub?ring=celiac Welcome to Medscape http://www.medscape.com/px/urlinfo Welcome to MedWeb http://medweb.bham.ac.uk/ Welcome to the Gluten Intolerance Group of North America http://www.gluten.net/ Welcome to the Incredible Edible Egg Website http://www.aeb.org/ www.patientcenters.com -- Non-Hodgkin's Lymphoma Center -- What are the NHLs http://www.patientcenters.com/lymphoma/news/nhl2.html York Nutritional Laboratories, Inc... Better health begins at home http://www.yorkallergyusa.com/ [Report] Treatment Algorithms 2000(Table of Contents) http://www.the-infoshop.com/study/dc...rithm_toc.html ================================================== =========== |
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What it all does to us.......
excuse me, IBS!
"Sseaott" SseaottATcomcastDOTnet wrote in message ... I'm a kid? Nice to know you know who I am when you don't know me lol. This is a newsgroup about carbs, NOT IMBS! ONCE AGAIN P L O N K ! "TavliGal" wrote in message news:7labc.10560$oR5.813@pd7tw3no... Laurence wrote: What? Wrong place to post this? How many here have IBS? Or similar? Don't worry about him Laurence, he's just a kid and a twit to boot. He "plonks" everyone he doesn't agree with or likes. I've heard of a few people who have IBS around here. Monica -- Started 01/20/04 362/322.4/250 __________________________________________________ ______ "Watch what people are cynical about, and one can often discover what they lack. - Harry Emerson Fosdick --- Outgoing mail is certified Virus Free. Checked by AVG anti-virus system (http://www.grisoft.com). Version: 6.0.644 / Virus Database: 412 - Release Date: 3/26/04 |
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