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What it all does to us.......



 
 
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Old April 2nd, 2004, 07:31 AM
Laurence
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Posts: n/a
Default What it all does to us.......

I am Laurence Harris. I live near Seattle, Washington, USA. I have Celiac
Disorder, Hashimoto's Thyroiditis, and about five other brushes with
autoimmune disorders. I have a BS degree, have read extensively in
chemistry, biochemistry, and broad ranging medical research topics. I have
been creating software for computers embedded in medical devices. Most
recently, software to operate a Left Ventricular Assist Device - a heart
pump, which is now successfully operating in at least two humans to good
effect.

After learning about the various medical problems that are associated with
gluten sensitive enteropathy, I saw a real puzzle staring at me. It became
a real teaser to me, and the more I learned, the more there seemed to be to
chase down. Since I have a lot of time available, I have jumped in with
both feet.

I have now spent months researching issues regarding how it is that many
people get AutoImmune Disorders, including Celiac Disease, Thyroiditis and a
whole host of others.

The linking of concepts presented here is my own invention, although all the
underlying technology is from the credible published technical works of many
others. I have relied only on legitimate sources, mostly medical journal
articles, although some comes from informational websites put up by various
professors at universities. Some of my information has come from years of
reading and study, although I have attempted to find current references for
most of it since science forges on.

I am inserting a huge list of website references at the end of the text.
They are the resources I used for most of my studies. Some of the websites
allow you to download entire journal articles as PDFs to store on your hard
drive. I do that wherever I can, since that works better than viewing them
in your browser. Unfortunately they are not grouped by topic, nor are they
in any particular order. To use many of them you must open the website and
drill down into areas having research papers, journal articles, patient
information and so on. There may be a few that require you to register to
be able to access the technical content.

The basic picture is that many people, more than have celiac disorder, have
an immune system that reacts to some parts of the gluten protein in wheat,
barley and rye. They interpret the protein as "enemy" - an antigen - just
as though it were a bacterium or virus. Since the immune system reacts to
foreign objects penetrating the skin, perhaps this explains why.

To follow all this you may want to go to some of the websites and read on
peptides, immune system, lymphocytes, acute and chronic inflammation.

The Immune System
The human body has wonderful ways of protecting itself. The system of
interacting parts that defends us from invading bacteria, fungi, viruses and
other foreign matter is collectively referred to as the "immune system". The
tale we are telling here is one not of allergies (IgE antibodies), but one
of a different, more insidious kind of immune system activity, (IgA, IgG and
IgM antibodies).
The immune system includes cells circulating in the blood and lymph and
cells in various other places as well. It includes a variety of cell types
from those that are self-moving blob-like hunter-killer cells (macrophages)
to several kinds of miniature chemical factories with some making
destructive toxins and others making specially shaped "antibodies" that
match up to and latch onto the fairly unique cell-surface chemicals used by
attacking organisms as tools or protective cover.
Blood serum, T-cells, B-cells, macrophages, antibodies, bone marrow, spleen,
lymphatic system, and various other organs all work together to detect and
destroy invasion forces. It has taken many millions of hours of research and
study for us to come as far as we have in our understanding of what happens
when a bacterium or virus attempts to invade our bodies. And while we have a
lot of the picture we are still learning, still searching for missing pieces
to this magnificent puzzle.

Cells
What we do know is that nearly every type of human cell encases fluids in a
cell wall made of a smooth, waterproof, very flexible double-layer of
loosely coupled rod-like molecules we call a plasma membrane. The cell wall
has various special structures embedded in it to transport materials across
the barrier. That is how food energy gets in and how waste products get out.
Inside each cell are a variety of different structures; some are tiny
chemical factories that convert glucose to ready-to-use chemical energy, and
use that energy for motion, or to create other special chemicals needed for
the cell's operation. Sometimes the chemicals are to sent out into the rest
of the human body for use elsewhere.

Cell Identity Flags - Friend or Foe?
But dotted all around on the outside of this smooth cell wall there are
several types of special "identity flags" - specially shaped chemicals that
are firmly anchored in the cell wall with a large specially shaped part
"waving in the breeze" telling all passing observers who they are - self. It
is not really quite that simplistic, but it is actually a combination of
several possible types of identity markers that are recognized by cells in
the immune system, telling them "Leave me alone! I'm a friend!" And
different types of tissue have slightly differently shaped flags, all still
self, but not quite all the same. These flags are called Human Leukocyte
Antigens (HLA) proteins.

Woe be unto cells, like bacteria, who don't know the right combination of
markers for "friend" - the immune system learns their surface markers,
creates a complimentary shaped pattern and attaches it to special proteins,
called antibodies, that hook onto the foes' flags and tell the immune system
"This is a bad guy! Let's take them out!" Once a particular immune system
cell recognizes an invader it can trigger cells whose job is to make
antibodies to reproduce and make lots more of these useful chemicals.

Immune Responses
Inflammation, created by the fast responders of the immune system, makes the
area surrounding a detected invasion become porous, or permeable, so that
antibodies and various immune system cells can "get at" the offenders. Even
blood vessel walls become rather leaky. This makes surrounding tissues swell
and turn red.

So the various parts of the immune system work to penetrate or perforate the
cell wall of an invading organism and make its insides all leak out. Some
immune system cells pick up the antigens and carry them around with them
like flags, telling other cells about the invader's identity. Some use the
antibody's matching pattern to latch onto the invading cells' surface
features (antigens) and get up against them to unleash little vesicles of
destructive chemicals. Others engulf an offender and digest it, or at least
they carry away indigestible stuff.

Picture these blob-like macrophages, fairly big as blood cells go, slipping
along in the blood stream and encountering a battle site - they send out an
amoeba-like tentacle, a pseudopod, and pull themselves over to a marked
offender, then they ooze around it and rejoin on the other side. When it is
fully engulfed they release chemicals, right up against the bad cell,
similar to chlorine bleach, that chemically take apart the proteins and
lipids that make up the invader's structure. Burp.

Even the lowly virus has chemical patterns that the immune system uses to
identify them. Virus surface coat chemicals are really tools to make the
virus stick to the surface of a human cell so they can get inside that cell.
And as a virus drills through the human cell wall it leaves behind various
parts of its surface coat, sort of embedded in and floating on the human
cell wall. These too are sensed by the immune system and used to identify
cells that are being taken over by a virus. These human cells then, are
mercilessly destroyed. And the methods work. Takes about two weeks for the
immune system to detect the invasion, learn the cell-surface markers left by
the viruses, make enough antibody factories ( B-Cells and others ), and do
the search and destroy job. When it is all done, and the antibody production
shuts down, there are extra of these chemical factories circulating in the
blood, sort of on standby, in case the same invaders come again. They would
be able to attack and destroy them before they ever get a foothold again.
That is learned immunity.

Immunity
Learned immunity is what we try to induce with a vaccine. A vaccine is just
a whole lot of these cell surface markers without the offending bacterium or
virus still attached, or at least if the cell is still there it has,
hopefully, been killed. Seems to work pretty well most of the time. So we
make a mixture of water with pieces of surface marker protein in it and
inject it into the inside of the body. The immune system sees the invading
stuff and sets up new antibody manufacturing to fight it off. Since there
are no real invaders, it is easy to clean up the debris, but the result is
that the immune system now has standby troops for that particular type of
invader. It is much better to learn immunity without having to suffer
through a full scale invasion.

The Flags are Proteins
So the cell surface markers are mostly bits of protein, which are really
just interconnected amino acids, which have shapes unique for that kind of
organism. Amino acids are some of the basic building blocks of the human
body. We get amino acids from eating and digesting meats and plant
materials, although some of them can be made by our own cells. Amino acids
also serve as a source of food energy when needed. Depending on what order
you string the amino acids together, and what other chemical bits you hook
onto the chain at various places, the whole thing folds into a three
dimensional shape. These proteins are sometimes referred to as "peptides".
(A peptide, then is just a piece of protein.) And shape is what is used by
antibodies to "recognize" a cell surface marker.

Intestinal Tract
The intestinal tract has a single cell layer, the epithelium that forms
villi - little finger-like projections that are filled with immune system
cells - lymphocytes - T cells, B cells, macrophages and so on. Below the
epithelium is something called the submucosa. and under all of it, or more
properly surrounding all of it is the muscular intestinal wall.

When gluten is present in the intestine, these immune system cells react,
and cause inflammation. Inflammation makes blood cell walls - epithelial
tissue - become leaky so that plasma containing antibodies can get at the
invasion more easily, along with lymphocytes. Unfortunately, the epithelial
wall of the intestine becomes leakier, too. It is a positive feedback loop
with inflammation.

And the worse the inflammation, the more of the gluten protein segments can
get in while other stuff is getting "out" into the digestive tract.

Antibodies
Well, one part of the immune response is to turn on the manufacture of
antibodies - chemicals that physically fit like hand and glove, or plug and
socket - that match up to the antigens. These little chemical factories are
in the B cells. And activating a B cell with a matching antibody causes it
to make antibodies and to replicate.

As long as antigen is being found, the B cells will be told by the T cells
and macrophages to make antibodies. Or is it the T helper cells that do
this? Any way the replicators get busy and the B cells get busy, flooding
the blood plasma with antibody chemicals that attach to the antigenic gluten
protein. Since gluten consumes the antibodies, they have to be replaced
when more gluten comes along.

Fuzzy Logic
Well, B cell replication is designed to not be perfect. The mechanisms that
transcribe the DNA/RNA stretches that encode antibody peptide sequences have
a built in randomizer that will occasionally substitute a different amino
acid into the sequence than was in the original. This apparently serves the
purpose of making the immune system more adaptable in case the original
match was not quite perfect. And if the new antibody shapes don't match
anything, they are never activated to make antibodies, and do not replicate
further.

So under a continuous attack from an antigen, such as gluten, the production
of antibodies is always running, perhaps even in high gear. And along with
this high rate of activity comes continual varying of the antibody patterns.

Unfortunately, many people have self-identification cell surface marker
peptides that bear a strong resemblance to gluten protein pieces. So when
the random variations in antibody shapes just happen to match fairly closely
with one of these usually protective Human Leukocyte Antigens (HLA), the
particular type of tissue in the human organism that bears that particular
variation of HLA is suddenly treated as a bad guy, as INVADER, instead of
SELF. And bang! There goes the thyroid producing cells. Or the Islets of
Langerhans insulin producing cells. Or any one of a whole lot of other
tissue types.

Endomysial tissue, a connective fibrous material surrounding muscle cells
apparently is one of the targets of attack, at least as long as gluten is
revving up the B cells. I'm not sure what the difference between this sort
of attack that only goes on as long as gluten is being consumed and the
thyroid or insulin cell attacks that seem to continue after gluten is
removed. Perhaps endomysial tissue is only in out-of-the-way places that
don't typically get visited by T cells or macrophages, and thus only suffer
when the antibodies are being produced in large amounts to fight off gluten.

That seems reasonable, since the gluten sets things going by showing up at
the intestinal inner wall epithelium which is just loaded with lymphocytes
to keep the fauna and flora of the inside of the intestine from getting
anywhere they shouldn't. And then there is apparently endomysial tissue in
the submucosa of the intestine? At any rate, the intestinal villi get
destroyed after a long enough time, and since that is where a lot of
digestive enzymes are produced, food doesn't get properly digested, and
since the surface area is smaller, it doesn't get properly absorbed.

So some of these tissue types are continually exposed to lymphocytes, and so
cause a sustained attack, while others seem to be typically sheltered, and
thus don't sustain antibody production when gluten is absent. And then
there is the increased risk of cancer that is associated with untreated CD.
Only is a problem when the immune system is churning away. Not when all is
quiescent.

All of this suggests that many people who never get Celiac Disease are still
experiencing varying degrees of intestinal inflammation from the consumption
of gluten. And there is a lot known about inflammation and its apparent
linkage to heart trouble, arthritis and a whole lot of other disorders. And
there are all the autoimmune disorders that seem to be the result of the
churning immune system hitting the wrong combination by accident.

There is even one website by a gastroenterologist suggesting that it could
be sixty percent or more of mankind that experiences this immune response
from gluten ingestion.

Various theories have been discussed that involved trigger events to start
off the attack against self causing an autoimmune disorder. I suspect that
that is not necessary, although it could play some role in starting some
autoimmune disorders in some people. Apparently H. Pylori bacteria, the
stuff of stomach ulcers, carried by the common housefly, can maintain a
chronic infection in the stomach that does the same sort of job as gluten in
the intestine. At least it maintains a constant inflammatory state, and has
an association with stomach cancers.

And supposedly there is an immune reaction in some people to bakers yeast.

So what to make of all of this? I think that because there is legitimate
research published about the increased risk of cancer in untreated Celiac
Disease (CD) patients, and that we have, in the US, only identified about
three per cent of those that actually have CD, that one could honestly make
a statement. about the safety of consuming gluten from wheat, barley or rye.

================================================== ===========

STATEMENT
"Since the ingestion of gluten from wheat, barley or rye has been
demonstrated, through clinical studies with humans, to cause an elevated
risk of cancer, gluten from wheat, barley and rye should be declared a
CARCINOGENIC SUBSTANCES. To do any less is to doom our children to the
lifetime of slow poisoning that most of us have been experiencing."


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University of Chicago Hospitals Celiac disease is far more common than
thought
http://www.uchospitals.edu/news/2003...210-celiac.php



Food Allergy & Anaphylaxis Network
http://www.foodallergy.org/


PBC Lab - Dr. Gershwin
http://internalmedicine.ucdmc.ucdavi...ology/PBC_Lab/


search engine for gluten free friendly inns, bed and breakfasts, and small
hotels
http://www.1-888-inn-seek.com/GFinns.htm


AAAAI - American Academy of Allergy Asthma and Immunology - www.aaaai.org
http://www.aaaai.org/


About.com http--www.autoimmunebook.com
http://thyroid.about.com/gi/dynamic/...munebook.c om


// Acute Inflammation UK BHAM
// http://medweb.bham.ac.uk/http/mod/3/1/a/acute.html


// adam.com Encyclopedia Disease Reference
// http://oso.adam.com/


Adenoviruses
http://www.tulane.edu/~dmsander/WWW/...noviruses.html


AllRefer Health - Autoimmune Disorders
http://health.allrefer.com/health/au...ders-info.html


AllRefer Health - Celiac Disease - Sprue Support Groups
http://health.allrefer.com/health/ce...e-support.html


Alt.Support.Thyroid Newsgroup Website
http://www.altsupportthyroid.org/


American Academy of Dermatology
http://www.aad.org/

American Academy of Dermatology
http://www.skincarephysicians.com/eczemanet/whatIs.html

American Association of Immunologists
http://www.aai.org/

American Association of Immunologists Journal
http://www.jimmunol.org/


American Peptide Society
http://www.ampepsoc.org/


American Pharmaceutical Online References
http://www.medicalresourcesusa.com/pharmrefguide.htm



American Thyroid Association
http://www.thyroid.org/


Antigen Receptor Diversity
http://users.rcn.com/jkimball.ma.ult...Diversity.html


Applied Biosystems
http://www.appliedbiosystems.com/


Archives of
http://maelstrom.stjohns.edu/archives/celiac.html


Aspiration Biopsy of the Thyroid
http://www.thyroidfoundation.org/aspiration.htm


Asthma and Allergy Information and Research (AAIR) Home Page
http://www.users.globalnet.co.uk/~aair/


Atkins Diet & Low Carbohydrate Weight-Loss Support - Low Carb Diet Recipes &
Resources
http://www.lowcarb.ca/


Atkins Nutritionals Home
http://atkinscenter.com/dev/


AuthenticFoods
http://www.authenticfoods.com/


Autoimmune Disorders
http://www.thedoctorsdoctor.com/dise..._disorders.htm


Autoimmunity AARDA American Autoimmune Related Diseases Association
http://www.aarda.org/


B Cells and T Cells
http://users.rcn.com/jkimball.ma.ult...nd_Tcells.html


BBC - Science & Nature - Horizon - The Atkins Diet
http://www.bbc.co.uk/science/horizon...instrans.shtml


Canadian Celiac Association
http://www.celiac.ca/englishcca.html


Candida, Fibromyalgia, IBS, Celiac, Colitis, yeast infections, thrush,
sinusitis, leaky gut syndrome,etc
http://www.candidafree.net/pages/1/index.htm


Candida
http://www.candidafree.net/pages/1/index.htm


Carrageenan, Food Resource [http--food.oregonstate.edu-], Oregon State
University, Corvallis, OR
http://food.oregonstate.edu/gums/carr.html


Case Study A 37-Year-Old Man With Type 1 Diabetes, Vomiting, and Diarrhea
http://journal.diabetes.org/clinical...1999/pg188.htm


CDC Health Topic Foodborne Illnesses
http://www.cdc.gov/health/foodill.htm


CELIAC (Celiac-Coeliac Wheat-Gluten-Free List)
http://www.enabling.org/ia/celiac/


Celiac Disease - DrGreene.com - caring for the next generation
http://www.drgreene.com/21_1522.html


Celiac Disease -- eCureMe.com
http://www.ecureme.com/emyhealth/Ped...ac_Disease.asp


Celiac disease and hypoparathyroidism cross-reaction of endomysial
antibodies with parathyroid tissue.
http://www.pubmedcentral.nih.gov/art...ype=abstrac t


Celiac Disease Foundation
http://www.celiac.org/


Celiac Disease NDDIC
http://digestive.niddk.nih.gov/ddise...liac/index.htm


Celiac Disease
http://digestive.niddk.nih.gov/ddise...liac/index.htm


Celiac Resources for Physicians
http://www.uams.edu/celiac/


Celiac Sprue Research Foundation
http://www.celiacsprue.org/


Celiac.com (Diagnosis & Treatment of Celiac Disease A Gluten-Free Diet)
http://www.celiac.com/cgi-bin/webc.c...37103580146.6d


CELLS alive!
http://www.cellsalive.com/index.htm


Center For Celiac Research
http://www.celiaccenter.org/


Center for Science in the Public Interest
http://cspinet.org/


ChemQuik® - Free MSDS MSDS Service Mobile MSDS Chemical Inventory AOS
http://www.chemquik.com/site/cq/welcome.asp


Chronic inflammatory cells
http://medweb.bham.ac.uk/http/depts/...F/infcell.html


Clan Thompson's Celiac Site
http://www.clanthompson.com/index.php3


Clinical Immunology Society
http://www.clinimmsoc.org/


Clonal Selection
http://users.rcn.com/jkimball.ma.ult...Selection.html


coeliac disease-gluten free info & message board (mainly UK)
http://coeliac.info/


Delphi Celiac Disease On-Line Support Group
http://forums.delphiforums.com/n/mai...li ac%2Fstart


Detecting Celiac Disease in Your Patients - March 1, 1998 - American Academy
of Family Physicians
http://www.aafp.org/afp/980301ap/pruessn.html


Diabetes Care The High Prevalence of Autoantibodies to Tissue
Transglutaminase in First-Degree Relatives
http://www.findarticles.com/cf_dls/m.../article.jhtml


Dietary Soluble Fiber Resource
http://www.gy.com/index.htm


Digestion and Balance
http://www.medhelp.org/forums/gastro...es/35622a.html


Electronic Code of Federal Regulations
http://ecfr.gpoaccess.gov/


EnteroLab
http://www.enterolab.com/


Entrez-PubMed
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi


eosinophils
http://www.nursing.ucla.edu/userpage...c/eosinoph.htm


FDA-CFSAN Food Labeling Overview
http://www.cfsan.fda.gov/label.html


FDA-CFSAN Information about Food Allergies
http://vm.cfsan.fda.gov/~dms/wh-alrgy.html


Food and Drug Administration Home Page
http://www.fda.gov/


Food Safety and Inspection Service Home Page
http://www.fsis.usda.gov/


foodallergynetwork.com
http://foodallergynetwork.com/


FoodNet (CDC)
http://www.cdc.gov/foodnet/


Gastroenterology
http://www2.gastrojournal.org/script...r=home&id=gast


Gluten Free Brewing Project
http://www.fortunecity.com/boozers/b...eer/gfbeer.htm


Gluten Free Medications
http://www.glutenfreedrugs.com/


Gluten Intolerance Group of North America
http://www.gluten.net/


Gluten-Free Trading Company Home Page
http://www.gluten-free.tc/


Glycogen Metabolism
http://www.indstate.edu/thcme/mwking/glycogen.html


GMA, Food Allergy Alliance Develop Easy to Understand Labeling Guidelines
GMA News Release 5-31-01
http://www.gmabrands.com/news/docs/N...cfm?DocID=767&


Google Search r-s medical
http://www.google.com/search?hl=en&i...&q=r-s+medical


Grain Inspection
http://www.usda.gov/gipsa/


GrainPuritySampling
http://www.usda.gov/gipsa/biotech/sample2.htm


GSDL Instestinal Permeability Assessment Application Guide
http://www.gsdl.com/assessments/ip/appguide/


Guar, Food Resource [http--food.oregonstate.edu-], Oregon State University,
Corvallis, OR
http://food.oregonstate.edu/gums/guar.html


Gum Arabic, Food Resource [http--food.oregonstate.edu-], Oregon State
University, Corvallis, OR
http://food.oregonstate.edu/gums/arabic.html


HealthScout
http://www.healthscout.com/


Hospital Practice Recognizing Thyrotoxicosis
http://www.hosppract.com/issues/1999/05/dmmmazz.htm


How Antibodies are Produced
http://www.cellsalive.com/antibody.htm


http--www.cvm.okstate.edu-instruction-kocan-vpar5333-5333iid.htm
http://www.cvm.okstate.edu/instructi...33/5333iid.htm


http--www.inel.gov-x-web-other-framed.shtmlhttp--www.sisweb.com
http://www.inel.gov/x-web/other/fram...www.sisweb.com


http--www.nal.usda.gov-fnic-foodcomp-search-
http://www.nal.usda.gov/fnic/foodcomp/search/


http--www.whatnowheat.com-
http://www.whatnowheat.com/


Hypothyroidism and the TSH Reference Range - Alt.Support.Thyroid Newsgroup
Website
http://www.altsupportthyroid.org/tsh/tshmedrefs1.php


IBM Life Sciences Web Lecture Series
http://www.ibmweblectureservices.iho...rigin=103ALE3S


IMMUNE DEFICIENCY FOUNDATION
http://www.primaryimmune.org/


Immune Recognition of the Mycobacterial Cell Wall
http://www.eurekah.com/abstract.php?...id=69&catid=73


Immune Tolerance Network - Industry Partnerships
http://www.immunetolerance.org/industry/


Immune Tolerance Network
http://www.immunetolerance.org/


Immune Web -- Support and Information Network
http://www.immuneweb.org/


Immunology of Diabetes Society Home Page
http://www.idsoc.org/


IMMUNOSCIENCES LAB.
http://www.immuno-sci-lab.com/2003_cat_page64.htm


Inflammation Long-Term Effects, from Arthritis.com
http://www.arthritis.com/1_5.asp


Inflammation Research Association
http://www.inflammationresearch.org/


Inflammation The Battle Within
http://arthritis.about.com/cs/arthge...flammation.htm


Inflammation, Heart Disease and Stroke The Role of C-Reactive Protein
http://www.americanheart.org/present...dentifier=4648


INFOMED ONLINE
http://www.infomed.org/



International Society for Mountain Medicine
http://www.ismmed.org/



Is Subclinical Gluten Intolerance-Celiac Disease Sabotaging Your Health -
Thyroid Disease Information
http://www.thyroid-info.com/articles/glutenceliac.htm


Kaili's Kitchen
http://www.wheatlessinseattle.com/


Kimball's Biology Pages
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/


Lab Tests Online Welcome!
http://www.labtestsonline.org/


LAMISIL - Nail fungus treatment, tips for healthy nails
http://www.lamisil.com/index.jsp?checked=y


Legacy Laboratory Services - Legacy Health System - Portland, OR
http://www.legacyhealth.org/healthca...php?testid=387


Lipids Online - Educational Resources in Atherosclerosis and Coronary Heart
Disease
http://www.lipidsonline.org/


Low Carb Research, Atkins Diet Research, Low Carb Diet Research
http://www.lowcarbresearch.org/lcr/results.asp


LOW CARBOHYDRATE RECIPES
http://www.carb-lite.au.com/fdbreakfast.html


Lymphoma Patients Information Resources
http://www.lymphoma.org.uk/support/i...on/Default.htm


Lymphoma Research Foundation Learning About Lymphoma
http://www.lymphoma.org/site/PageSer...ename=learning


Lymphoma Research Foundation
http://www.lymphoma.org/site/PageSer...gename=Seattle


Macular Pucker
http://www.vrmny.com/ERM.htm


Making Your Voice Heard at FDA How to Comment on Proposed Regulations and
Submit Petitions
http://www.fda.gov/opacom/backgrounders/voice.html


MayoClinic.com - Medical and health information for a healthier life from
Mayo Clinic
http://www.mayoclinic.com/invoke.cfm?id=DS00319


MDDI
http://www.devicelink.com/mddi/


MedicineNetInformation on Celiac disease
http://www.medicinenet.com/Celiac_Disease/article.htm


MedlinePlus Celiac Disease
http://www.nlm.nih.gov/medlineplus/celiacdisease.html


MEDLINEplus Health Information from the National Library of Medicine
http://www.nlm.nih.gov/medlineplus/medlineplus.html


MedlinePlus Medical Encyclopedia Autoimmune disorders
http://www.nlm.nih.gov/medlineplus/e...cle/000816.htm


Metabolic Pathways of Biochemistry
http://www.gwu.edu/~mpb/


Molecular Immunology
http://www.mi.interhealth.info/


Monterey Bay Aquarium Seafood Watch Program - Regional Seafood Watch Cards
http://www.mbayaq.org/cr/cr_seafoodw...w_regional.asp


Muscle Biopsy
http://www.neuro.wustl.edu/neuromusc...ab/mbiopsy.htm


National Institute of Allergy and Infectious Diseases Home Page (NIAID),
National Institutes of Health
http://www.niaid.nih.gov/default.htm


National Institute of Neurological Disorders and Stroke (NINDS)
http://www.ninds.nih.gov/


National Institute of Standards and Technology
http://nist.gov/


National Pork Producers Council
http://www.nppc.org/


Neuromuscular Muscle Autoantibodies
http://www.neuro.wustl.edu/neuromusc...mantibody.html


NIAID Links to Other Sites
http://www.niaid.nih.gov/information/externallinks.htm


Nikon MicroscopyU Confocal Image Gallery - Peyer's Patches
http://www.microscopyu.com/galleries...rspatches.html


NLM's Databases and Electronic Information Sources
http://www.nlm.nih.gov/databases/databases.html


No WorriesT Gluten-Free Bread Mix
http://www.noworriesbread.com/


OMIM - CELIAC DISEASE; CD
http://www.ncbi.nlm.nih.gov/entrez/d....cgi?id=212750


Pathology Teaching Menu
http://medweb.bham.ac.uk/http/depts/.../teachdir.html


Peptide bond - Wikipedia
http://en.wikipedia.org/wiki/Peptide_bond


Periodic table (WebElements)
http://www.webelements.com/


Planet Celiac--the gluten free place to be if you have celiac sprue --
recipes, books and more.
http://www.planetceliac.com/


PorkBoard
http://www.porkboard.org/Home/default.asp


PROWL - Amino Acid Properties
http://prowl.rockefeller.edu/aainfo/contents.htm


PsoriasisNet
http://www.skincarephysicians.com/ps...snet/index.htm


Science of dieting Slim pickings
http://www.nature.com/cgi-taf/DynaPa...28252a_fs.html


Seattle Celiac Support Group
http://www.seattleceliacs.com/


Seborrheic Dermatitis
http://www.aad.org/pamphlets/seborrhe.html


Skindex
http://www.skindex.com/index.html


Society for Mucosal Immunology
http://www.socmucimm.org/


Special Communication - March 8, 1995. Treatment Guidelines for
Hyperthyroidism and Hypothyroid
http://www.ama-assn.org/sci-pubs/jou..._10/sc4291.htm



Special Communication - March 8, 1995. Treatment Guidelines for
Hyperthyroidism and Hypothyroidism. (c) AMA 1996
http://www.ama-assn.org/sci-pubs/jou..._10/sc4291.htm


Specialty Laboratories - clinical reference laboratory contract research
organization
http://www.specialtylabs.com/


StopAllergy.com Ask an Allergist
http://allergist.stopallergy.com/For...lth/Allergist/


Support Groups
http://www.whatnowheat.com/Support%20Groups.htm


Swedish Medical Center Home
http://www.swedish.org/home.asp?Home


The American Gastroenterological Association - Clinical Resources (Patient
Brochures)
http://www.gastro.org/clinicalRes/brochures/ibd.html


The American Gastroenterological Association
http://www.gastro.org/


The Antibody Resource Page educational
http://www.antibodyresource.com/educational.html


The Gluten Free Kitchen
http://gfkitchen.server101.com/


The gluten free message board
http://members2.boardhost.com/gluten...html?999235741


The Great Plains Laboratory, your center of testing and analysis for Autism,
Pervasive Developmental Disorder (PDD)
http://www.greatplainslaboratory.com/immune.html


The Merck Manual
http://www.merck.com/pubs/


The National Fibromyalgia Association
http://www.fmaware.org/


Thinner - guide to lowcarb weight loss
http://www.thinner.com/


ThirdAge - Health Newsletter - Overlooked, Under-Diagnosed Thyroid Disease
Poses a Challenge
http://www.thirdage.com/news/article...040326-01.html


Thyroid Disease Manager, your source on thyroid disease, hyperthyroidism,
hypothyroidism, thyroiditis,thyroid cancer
http://www.thyroidmanager.org/


Thyroid Disease Symptoms - Hypothyroidism Symptoms
http://www.armourthyroid.com/hypothy.../symptoms.html


TNFA promoter polymorphism and susceptibility to brucellosis - Clin Exp
Immunol, Vol 121, Issue 3, pp. 480-483 (Full Text)
http://www.blackwell-synergy.com/lin....01331.x/full/


Two distinct hemolysins in Trichomonas tenax ATCC 30207 - Oral Microbiol
Immunol, Vol 15, Issue 6, pp. 355-359 (Abstract)
http://www.blackwell-synergy.com/lin...d=bHR8zMK2xU2f

USDA NutrientDatabase
http://www.nal.usda.gov/fnic/foodcomp/search/


Van's Wheat Free Waffles.
http://www.vansintl.com/wheatfree.php


VCUendomysiumResident Cases
http://www.pathology.vcu.edu/WirSelfInst/muscle.html


virus-adeno
http://www.stanford.edu/group/virus/adeno/adeno.html


Voluntary Recall of Taco Bell Taco Shells containing StarLink Corn
http://www.cast-science.org/cast-sci...y/20000925.htm


WAFDO
http://www.wafdo.org/


WebRing hub
http://j.webring.com/hub?ring=celiac


Welcome to Medscape
http://www.medscape.com/px/urlinfo


Welcome to MedWeb
http://medweb.bham.ac.uk/


Welcome to the Gluten Intolerance Group of North America
http://www.gluten.net/


Welcome to the Incredible Edible Egg Website
http://www.aeb.org/


www.patientcenters.com -- Non-Hodgkin's Lymphoma Center -- What are the NHLs
http://www.patientcenters.com/lymphoma/news/nhl2.html


York Nutritional Laboratories, Inc... Better health begins at home
http://www.yorkallergyusa.com/


[Report] Treatment Algorithms 2000(Table of Contents)
http://www.the-infoshop.com/study/dc...rithm_toc.html




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  #2  
Old April 2nd, 2004, 08:23 AM
Sseaott
external usenet poster
 
Posts: n/a
Default What it all does to us.......

P

L

O

N

K
"Laurence" lharris@nwlinkDOTcom wrote in message
...
I am Laurence Harris. I live near Seattle, Washington, USA. I have

Celiac
Disorder, Hashimoto's Thyroiditis, and about five other brushes with
autoimmune disorders. I have a BS degree, have read extensively in
chemistry, biochemistry, and broad ranging medical research topics. I

have
been creating software for computers embedded in medical devices. Most
recently, software to operate a Left Ventricular Assist Device - a heart
pump, which is now successfully operating in at least two humans to good
effect.

After learning about the various medical problems that are associated with
gluten sensitive enteropathy, I saw a real puzzle staring at me. It

became
a real teaser to me, and the more I learned, the more there seemed to be

to
chase down. Since I have a lot of time available, I have jumped in with
both feet.

I have now spent months researching issues regarding how it is that many
people get AutoImmune Disorders, including Celiac Disease, Thyroiditis and

a
whole host of others.

The linking of concepts presented here is my own invention, although all

the
underlying technology is from the credible published technical works of

many
others. I have relied only on legitimate sources, mostly medical journal
articles, although some comes from informational websites put up by

various
professors at universities. Some of my information has come from years of
reading and study, although I have attempted to find current references

for
most of it since science forges on.

I am inserting a huge list of website references at the end of the text.
They are the resources I used for most of my studies. Some of the

websites
allow you to download entire journal articles as PDFs to store on your

hard
drive. I do that wherever I can, since that works better than viewing

them
in your browser. Unfortunately they are not grouped by topic, nor are

they
in any particular order. To use many of them you must open the website

and
drill down into areas having research papers, journal articles, patient
information and so on. There may be a few that require you to register to
be able to access the technical content.

The basic picture is that many people, more than have celiac disorder,

have
an immune system that reacts to some parts of the gluten protein in wheat,
barley and rye. They interpret the protein as "enemy" - an antigen -

just
as though it were a bacterium or virus. Since the immune system reacts to
foreign objects penetrating the skin, perhaps this explains why.

To follow all this you may want to go to some of the websites and read on
peptides, immune system, lymphocytes, acute and chronic inflammation.

The Immune System
The human body has wonderful ways of protecting itself. The system of
interacting parts that defends us from invading bacteria, fungi, viruses

and
other foreign matter is collectively referred to as the "immune system".

The
tale we are telling here is one not of allergies (IgE antibodies), but one
of a different, more insidious kind of immune system activity, (IgA, IgG

and
IgM antibodies).
The immune system includes cells circulating in the blood and lymph and
cells in various other places as well. It includes a variety of cell types
from those that are self-moving blob-like hunter-killer cells

(macrophages)
to several kinds of miniature chemical factories with some making
destructive toxins and others making specially shaped "antibodies" that
match up to and latch onto the fairly unique cell-surface chemicals used

by
attacking organisms as tools or protective cover.
Blood serum, T-cells, B-cells, macrophages, antibodies, bone marrow,

spleen,
lymphatic system, and various other organs all work together to detect and
destroy invasion forces. It has taken many millions of hours of research

and
study for us to come as far as we have in our understanding of what

happens
when a bacterium or virus attempts to invade our bodies. And while we have

a
lot of the picture we are still learning, still searching for missing

pieces
to this magnificent puzzle.

Cells
What we do know is that nearly every type of human cell encases fluids in

a
cell wall made of a smooth, waterproof, very flexible double-layer of
loosely coupled rod-like molecules we call a plasma membrane. The cell

wall
has various special structures embedded in it to transport materials

across
the barrier. That is how food energy gets in and how waste products get

out.
Inside each cell are a variety of different structures; some are tiny
chemical factories that convert glucose to ready-to-use chemical energy,

and
use that energy for motion, or to create other special chemicals needed

for
the cell's operation. Sometimes the chemicals are to sent out into the

rest
of the human body for use elsewhere.

Cell Identity Flags - Friend or Foe?
But dotted all around on the outside of this smooth cell wall there are
several types of special "identity flags" - specially shaped chemicals

that
are firmly anchored in the cell wall with a large specially shaped part
"waving in the breeze" telling all passing observers who they are - self.

It
is not really quite that simplistic, but it is actually a combination of
several possible types of identity markers that are recognized by cells in
the immune system, telling them "Leave me alone! I'm a friend!" And
different types of tissue have slightly differently shaped flags, all

still
self, but not quite all the same. These flags are called Human Leukocyte
Antigens (HLA) proteins.

Woe be unto cells, like bacteria, who don't know the right combination of
markers for "friend" - the immune system learns their surface markers,
creates a complimentary shaped pattern and attaches it to special

proteins,
called antibodies, that hook onto the foes' flags and tell the immune

system
"This is a bad guy! Let's take them out!" Once a particular immune system
cell recognizes an invader it can trigger cells whose job is to make
antibodies to reproduce and make lots more of these useful chemicals.

Immune Responses
Inflammation, created by the fast responders of the immune system, makes

the
area surrounding a detected invasion become porous, or permeable, so that
antibodies and various immune system cells can "get at" the offenders.

Even
blood vessel walls become rather leaky. This makes surrounding tissues

swell
and turn red.

So the various parts of the immune system work to penetrate or perforate

the
cell wall of an invading organism and make its insides all leak out. Some
immune system cells pick up the antigens and carry them around with them
like flags, telling other cells about the invader's identity. Some use the
antibody's matching pattern to latch onto the invading cells' surface
features (antigens) and get up against them to unleash little vesicles of
destructive chemicals. Others engulf an offender and digest it, or at

least
they carry away indigestible stuff.

Picture these blob-like macrophages, fairly big as blood cells go,

slipping
along in the blood stream and encountering a battle site - they send out

an
amoeba-like tentacle, a pseudopod, and pull themselves over to a marked
offender, then they ooze around it and rejoin on the other side. When it

is
fully engulfed they release chemicals, right up against the bad cell,
similar to chlorine bleach, that chemically take apart the proteins and
lipids that make up the invader's structure. Burp.

Even the lowly virus has chemical patterns that the immune system uses to
identify them. Virus surface coat chemicals are really tools to make the
virus stick to the surface of a human cell so they can get inside that

cell.
And as a virus drills through the human cell wall it leaves behind various
parts of its surface coat, sort of embedded in and floating on the human
cell wall. These too are sensed by the immune system and used to identify
cells that are being taken over by a virus. These human cells then, are
mercilessly destroyed. And the methods work. Takes about two weeks for the
immune system to detect the invasion, learn the cell-surface markers left

by
the viruses, make enough antibody factories ( B-Cells and others ), and do
the search and destroy job. When it is all done, and the antibody

production
shuts down, there are extra of these chemical factories circulating in the
blood, sort of on standby, in case the same invaders come again. They

would
be able to attack and destroy them before they ever get a foothold again.
That is learned immunity.

Immunity
Learned immunity is what we try to induce with a vaccine. A vaccine is

just
a whole lot of these cell surface markers without the offending bacterium

or
virus still attached, or at least if the cell is still there it has,
hopefully, been killed. Seems to work pretty well most of the time. So we
make a mixture of water with pieces of surface marker protein in it and
inject it into the inside of the body. The immune system sees the invading
stuff and sets up new antibody manufacturing to fight it off. Since there
are no real invaders, it is easy to clean up the debris, but the result is
that the immune system now has standby troops for that particular type of
invader. It is much better to learn immunity without having to suffer
through a full scale invasion.

The Flags are Proteins
So the cell surface markers are mostly bits of protein, which are really
just interconnected amino acids, which have shapes unique for that kind of
organism. Amino acids are some of the basic building blocks of the human
body. We get amino acids from eating and digesting meats and plant
materials, although some of them can be made by our own cells. Amino acids
also serve as a source of food energy when needed. Depending on what order
you string the amino acids together, and what other chemical bits you hook
onto the chain at various places, the whole thing folds into a three
dimensional shape. These proteins are sometimes referred to as "peptides".
(A peptide, then is just a piece of protein.) And shape is what is used by
antibodies to "recognize" a cell surface marker.

Intestinal Tract
The intestinal tract has a single cell layer, the epithelium that forms
villi - little finger-like projections that are filled with immune system
cells - lymphocytes - T cells, B cells, macrophages and so on. Below the
epithelium is something called the submucosa. and under all of it, or more
properly surrounding all of it is the muscular intestinal wall.

When gluten is present in the intestine, these immune system cells react,
and cause inflammation. Inflammation makes blood cell walls - epithelial
tissue - become leaky so that plasma containing antibodies can get at the
invasion more easily, along with lymphocytes. Unfortunately, the

epithelial
wall of the intestine becomes leakier, too. It is a positive feedback

loop
with inflammation.

And the worse the inflammation, the more of the gluten protein segments

can
get in while other stuff is getting "out" into the digestive tract.

Antibodies
Well, one part of the immune response is to turn on the manufacture of
antibodies - chemicals that physically fit like hand and glove, or plug

and
socket - that match up to the antigens. These little chemical factories

are
in the B cells. And activating a B cell with a matching antibody causes

it
to make antibodies and to replicate.

As long as antigen is being found, the B cells will be told by the T cells
and macrophages to make antibodies. Or is it the T helper cells that do
this? Any way the replicators get busy and the B cells get busy, flooding
the blood plasma with antibody chemicals that attach to the antigenic

gluten
protein. Since gluten consumes the antibodies, they have to be replaced
when more gluten comes along.

Fuzzy Logic
Well, B cell replication is designed to not be perfect. The mechanisms

that
transcribe the DNA/RNA stretches that encode antibody peptide sequences

have
a built in randomizer that will occasionally substitute a different amino
acid into the sequence than was in the original. This apparently serves

the
purpose of making the immune system more adaptable in case the original
match was not quite perfect. And if the new antibody shapes don't match
anything, they are never activated to make antibodies, and do not

replicate
further.

So under a continuous attack from an antigen, such as gluten, the

production
of antibodies is always running, perhaps even in high gear. And along

with
this high rate of activity comes continual varying of the antibody

patterns.

Unfortunately, many people have self-identification cell surface marker
peptides that bear a strong resemblance to gluten protein pieces. So when
the random variations in antibody shapes just happen to match fairly

closely
with one of these usually protective Human Leukocyte Antigens (HLA), the
particular type of tissue in the human organism that bears that particular
variation of HLA is suddenly treated as a bad guy, as INVADER, instead of
SELF. And bang! There goes the thyroid producing cells. Or the Islets of
Langerhans insulin producing cells. Or any one of a whole lot of other
tissue types.

Endomysial tissue, a connective fibrous material surrounding muscle cells
apparently is one of the targets of attack, at least as long as gluten is
revving up the B cells. I'm not sure what the difference between this

sort
of attack that only goes on as long as gluten is being consumed and the
thyroid or insulin cell attacks that seem to continue after gluten is
removed. Perhaps endomysial tissue is only in out-of-the-way places that
don't typically get visited by T cells or macrophages, and thus only

suffer
when the antibodies are being produced in large amounts to fight off

gluten.

That seems reasonable, since the gluten sets things going by showing up at
the intestinal inner wall epithelium which is just loaded with lymphocytes
to keep the fauna and flora of the inside of the intestine from getting
anywhere they shouldn't. And then there is apparently endomysial tissue

in
the submucosa of the intestine? At any rate, the intestinal villi get
destroyed after a long enough time, and since that is where a lot of
digestive enzymes are produced, food doesn't get properly digested, and
since the surface area is smaller, it doesn't get properly absorbed.

So some of these tissue types are continually exposed to lymphocytes, and

so
cause a sustained attack, while others seem to be typically sheltered, and
thus don't sustain antibody production when gluten is absent. And then
there is the increased risk of cancer that is associated with untreated

CD.
Only is a problem when the immune system is churning away. Not when all

is
quiescent.

All of this suggests that many people who never get Celiac Disease are

still
experiencing varying degrees of intestinal inflammation from the

consumption
of gluten. And there is a lot known about inflammation and its apparent
linkage to heart trouble, arthritis and a whole lot of other disorders.

And
there are all the autoimmune disorders that seem to be the result of the
churning immune system hitting the wrong combination by accident.

There is even one website by a gastroenterologist suggesting that it could
be sixty percent or more of mankind that experiences this immune response
from gluten ingestion.

Various theories have been discussed that involved trigger events to start
off the attack against self causing an autoimmune disorder. I suspect

that
that is not necessary, although it could play some role in starting some
autoimmune disorders in some people. Apparently H. Pylori bacteria, the
stuff of stomach ulcers, carried by the common housefly, can maintain a
chronic infection in the stomach that does the same sort of job as gluten

in
the intestine. At least it maintains a constant inflammatory state, and

has
an association with stomach cancers.

And supposedly there is an immune reaction in some people to bakers yeast.

So what to make of all of this? I think that because there is legitimate
research published about the increased risk of cancer in untreated Celiac
Disease (CD) patients, and that we have, in the US, only identified about
three per cent of those that actually have CD, that one could honestly

make
a statement. about the safety of consuming gluten from wheat, barley or

rye.

================================================== ===========

STATEMENT
"Since the ingestion of gluten from wheat, barley or rye has been
demonstrated, through clinical studies with humans, to cause an elevated
risk of cancer, gluten from wheat, barley and rye should be declared a
CARCINOGENIC SUBSTANCES. To do any less is to doom our children to the
lifetime of slow poisoning that most of us have been experiencing."


================================================== ===========
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================================================== ===========


University of Chicago Hospitals Celiac disease is far more common than
thought
http://www.uchospitals.edu/news/2003...210-celiac.php



Food Allergy & Anaphylaxis Network
http://www.foodallergy.org/


PBC Lab - Dr. Gershwin
http://internalmedicine.ucdmc.ucdavi...ology/PBC_Lab/


search engine for gluten free friendly inns, bed and breakfasts, and small
hotels
http://www.1-888-inn-seek.com/GFinns.htm


AAAAI - American Academy of Allergy Asthma and Immunology - www.aaaai.org
http://www.aaaai.org/


About.com http--www.autoimmunebook.com

http://thyroid.about.com/gi/dynamic/...munebook.c om


// Acute Inflammation UK BHAM
// http://medweb.bham.ac.uk/http/mod/3/1/a/acute.html


// adam.com Encyclopedia Disease Reference
// http://oso.adam.com/


Adenoviruses
http://www.tulane.edu/~dmsander/WWW/...noviruses.html


AllRefer Health - Autoimmune Disorders
http://health.allrefer.com/health/au...ders-info.html


AllRefer Health - Celiac Disease - Sprue Support Groups
http://health.allrefer.com/health/ce...e-support.html


Alt.Support.Thyroid Newsgroup Website
http://www.altsupportthyroid.org/


American Academy of Dermatology
http://www.aad.org/

American Academy of Dermatology
http://www.skincarephysicians.com/eczemanet/whatIs.html

American Association of Immunologists
http://www.aai.org/

American Association of Immunologists Journal
http://www.jimmunol.org/


American Peptide Society
http://www.ampepsoc.org/


American Pharmaceutical Online References
http://www.medicalresourcesusa.com/pharmrefguide.htm



American Thyroid Association
http://www.thyroid.org/


Antigen Receptor Diversity

http://users.rcn.com/jkimball.ma.ult...Diversity.html


Applied Biosystems
http://www.appliedbiosystems.com/


Archives of
http://maelstrom.stjohns.edu/archives/celiac.html


Aspiration Biopsy of the Thyroid
http://www.thyroidfoundation.org/aspiration.htm


Asthma and Allergy Information and Research (AAIR) Home Page
http://www.users.globalnet.co.uk/~aair/


Atkins Diet & Low Carbohydrate Weight-Loss Support - Low Carb Diet Recipes

&
Resources
http://www.lowcarb.ca/


Atkins Nutritionals Home
http://atkinscenter.com/dev/


AuthenticFoods
http://www.authenticfoods.com/


Autoimmune Disorders
http://www.thedoctorsdoctor.com/dise..._disorders.htm


Autoimmunity AARDA American Autoimmune Related Diseases Association
http://www.aarda.org/


B Cells and T Cells
http://users.rcn.com/jkimball.ma.ult...nd_Tcells.html


BBC - Science & Nature - Horizon - The Atkins Diet
http://www.bbc.co.uk/science/horizon...instrans.shtml


Canadian Celiac Association
http://www.celiac.ca/englishcca.html


Candida, Fibromyalgia, IBS, Celiac, Colitis, yeast infections, thrush,
sinusitis, leaky gut syndrome,etc
http://www.candidafree.net/pages/1/index.htm


Candida
http://www.candidafree.net/pages/1/index.htm


Carrageenan, Food Resource [http--food.oregonstate.edu-], Oregon State
University, Corvallis, OR
http://food.oregonstate.edu/gums/carr.html


Case Study A 37-Year-Old Man With Type 1 Diabetes, Vomiting, and Diarrhea
http://journal.diabetes.org/clinical...1999/pg188.htm


CDC Health Topic Foodborne Illnesses
http://www.cdc.gov/health/foodill.htm


CELIAC (Celiac-Coeliac Wheat-Gluten-Free List)
http://www.enabling.org/ia/celiac/


Celiac Disease - DrGreene.com - caring for the next generation
http://www.drgreene.com/21_1522.html


Celiac Disease -- eCureMe.com
http://www.ecureme.com/emyhealth/Ped...ac_Disease.asp


Celiac disease and hypoparathyroidism cross-reaction of endomysial
antibodies with parathyroid tissue.

http://www.pubmedcentral.nih.gov/art...ype=abstrac t


Celiac Disease Foundation
http://www.celiac.org/


Celiac Disease NDDIC
http://digestive.niddk.nih.gov/ddise...liac/index.htm


Celiac Disease
http://digestive.niddk.nih.gov/ddise...liac/index.htm


Celiac Resources for Physicians
http://www.uams.edu/celiac/


Celiac Sprue Research Foundation
http://www.celiacsprue.org/


Celiac.com (Diagnosis & Treatment of Celiac Disease A Gluten-Free Diet)

http://www.celiac.com/cgi-bin/webc.c...37103580146.6d


CELLS alive!
http://www.cellsalive.com/index.htm


Center For Celiac Research
http://www.celiaccenter.org/


Center for Science in the Public Interest
http://cspinet.org/


ChemQuik® - Free MSDS MSDS Service Mobile MSDS Chemical Inventory AOS
http://www.chemquik.com/site/cq/welcome.asp


Chronic inflammatory cells

http://medweb.bham.ac.uk/http/depts/...F/infcell.html


Clan Thompson's Celiac Site
http://www.clanthompson.com/index.php3


Clinical Immunology Society
http://www.clinimmsoc.org/


Clonal Selection

http://users.rcn.com/jkimball.ma.ult...Selection.html


coeliac disease-gluten free info & message board (mainly UK)
http://coeliac.info/


Delphi Celiac Disease On-Line Support Group

http://forums.delphiforums.com/n/mai...li ac%2Fstart


Detecting Celiac Disease in Your Patients - March 1, 1998 - American

Academy
of Family Physicians
http://www.aafp.org/afp/980301ap/pruessn.html


Diabetes Care The High Prevalence of Autoantibodies to Tissue
Transglutaminase in First-Degree Relatives
http://www.findarticles.com/cf_dls/m.../article.jhtml


Dietary Soluble Fiber Resource
http://www.gy.com/index.htm


Digestion and Balance
http://www.medhelp.org/forums/gastro...es/35622a.html


Electronic Code of Federal Regulations
http://ecfr.gpoaccess.gov/


EnteroLab
http://www.enterolab.com/


Entrez-PubMed
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi


eosinophils
http://www.nursing.ucla.edu/userpage...c/eosinoph.htm


FDA-CFSAN Food Labeling Overview
http://www.cfsan.fda.gov/label.html


FDA-CFSAN Information about Food Allergies
http://vm.cfsan.fda.gov/~dms/wh-alrgy.html


Food and Drug Administration Home Page
http://www.fda.gov/


Food Safety and Inspection Service Home Page
http://www.fsis.usda.gov/


foodallergynetwork.com
http://foodallergynetwork.com/


FoodNet (CDC)
http://www.cdc.gov/foodnet/


Gastroenterology

http://www2.gastrojournal.org/script...r=home&id=gast


Gluten Free Brewing Project
http://www.fortunecity.com/boozers/b...eer/gfbeer.htm


Gluten Free Medications
http://www.glutenfreedrugs.com/


Gluten Intolerance Group of North America
http://www.gluten.net/


Gluten-Free Trading Company Home Page
http://www.gluten-free.tc/


Glycogen Metabolism
http://www.indstate.edu/thcme/mwking/glycogen.html


GMA, Food Allergy Alliance Develop Easy to Understand Labeling Guidelines
GMA News Release 5-31-01
http://www.gmabrands.com/news/docs/N...cfm?DocID=767&


Google Search r-s medical
http://www.google.com/search?hl=en&i...&q=r-s+medical


Grain Inspection
http://www.usda.gov/gipsa/


GrainPuritySampling
http://www.usda.gov/gipsa/biotech/sample2.htm


GSDL Instestinal Permeability Assessment Application Guide
http://www.gsdl.com/assessments/ip/appguide/


Guar, Food Resource [http--food.oregonstate.edu-], Oregon State

University,
Corvallis, OR
http://food.oregonstate.edu/gums/guar.html


Gum Arabic, Food Resource [http--food.oregonstate.edu-], Oregon State
University, Corvallis, OR
http://food.oregonstate.edu/gums/arabic.html


HealthScout
http://www.healthscout.com/


Hospital Practice Recognizing Thyrotoxicosis
http://www.hosppract.com/issues/1999/05/dmmmazz.htm


How Antibodies are Produced
http://www.cellsalive.com/antibody.htm


http--www.cvm.okstate.edu-instruction-kocan-vpar5333-5333iid.htm
http://www.cvm.okstate.edu/instructi...33/5333iid.htm


http--www.inel.gov-x-web-other-framed.shtmlhttp--www.sisweb.com
http://www.inel.gov/x-web/other/fram...www.sisweb.com


http--www.nal.usda.gov-fnic-foodcomp-search-
http://www.nal.usda.gov/fnic/foodcomp/search/


http--www.whatnowheat.com-
http://www.whatnowheat.com/


Hypothyroidism and the TSH Reference Range - Alt.Support.Thyroid Newsgroup
Website
http://www.altsupportthyroid.org/tsh/tshmedrefs1.php


IBM Life Sciences Web Lecture Series

http://www.ibmweblectureservices.iho...rigin=103ALE3S


IMMUNE DEFICIENCY FOUNDATION
http://www.primaryimmune.org/


Immune Recognition of the Mycobacterial Cell Wall
http://www.eurekah.com/abstract.php?...id=69&catid=73


Immune Tolerance Network - Industry Partnerships
http://www.immunetolerance.org/industry/


Immune Tolerance Network
http://www.immunetolerance.org/


Immune Web -- Support and Information Network
http://www.immuneweb.org/


Immunology of Diabetes Society Home Page
http://www.idsoc.org/


IMMUNOSCIENCES LAB.
http://www.immuno-sci-lab.com/2003_cat_page64.htm


Inflammation Long-Term Effects, from Arthritis.com
http://www.arthritis.com/1_5.asp


Inflammation Research Association
http://www.inflammationresearch.org/


Inflammation The Battle Within
http://arthritis.about.com/cs/arthge...flammation.htm


Inflammation, Heart Disease and Stroke The Role of C-Reactive Protein
http://www.americanheart.org/present...dentifier=4648


INFOMED ONLINE
http://www.infomed.org/



International Society for Mountain Medicine
http://www.ismmed.org/



Is Subclinical Gluten Intolerance-Celiac Disease Sabotaging Your Health -
Thyroid Disease Information
http://www.thyroid-info.com/articles/glutenceliac.htm


Kaili's Kitchen
http://www.wheatlessinseattle.com/


Kimball's Biology Pages
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/


Lab Tests Online Welcome!
http://www.labtestsonline.org/


LAMISIL - Nail fungus treatment, tips for healthy nails
http://www.lamisil.com/index.jsp?checked=y


Legacy Laboratory Services - Legacy Health System - Portland, OR
http://www.legacyhealth.org/healthca...php?testid=387


Lipids Online - Educational Resources in Atherosclerosis and Coronary

Heart
Disease
http://www.lipidsonline.org/


Low Carb Research, Atkins Diet Research, Low Carb Diet Research
http://www.lowcarbresearch.org/lcr/results.asp


LOW CARBOHYDRATE RECIPES
http://www.carb-lite.au.com/fdbreakfast.html


Lymphoma Patients Information Resources
http://www.lymphoma.org.uk/support/i...on/Default.htm


Lymphoma Research Foundation Learning About Lymphoma
http://www.lymphoma.org/site/PageSer...ename=learning


Lymphoma Research Foundation
http://www.lymphoma.org/site/PageSer...gename=Seattle


Macular Pucker
http://www.vrmny.com/ERM.htm


Making Your Voice Heard at FDA How to Comment on Proposed Regulations and
Submit Petitions
http://www.fda.gov/opacom/backgrounders/voice.html


MayoClinic.com - Medical and health information for a healthier life from
Mayo Clinic
http://www.mayoclinic.com/invoke.cfm?id=DS00319


MDDI
http://www.devicelink.com/mddi/


MedicineNetInformation on Celiac disease
http://www.medicinenet.com/Celiac_Disease/article.htm


MedlinePlus Celiac Disease
http://www.nlm.nih.gov/medlineplus/celiacdisease.html


MEDLINEplus Health Information from the National Library of Medicine
http://www.nlm.nih.gov/medlineplus/medlineplus.html


MedlinePlus Medical Encyclopedia Autoimmune disorders
http://www.nlm.nih.gov/medlineplus/e...cle/000816.htm


Metabolic Pathways of Biochemistry
http://www.gwu.edu/~mpb/


Molecular Immunology
http://www.mi.interhealth.info/


Monterey Bay Aquarium Seafood Watch Program - Regional Seafood Watch Cards
http://www.mbayaq.org/cr/cr_seafoodw...w_regional.asp


Muscle Biopsy
http://www.neuro.wustl.edu/neuromusc...ab/mbiopsy.htm


National Institute of Allergy and Infectious Diseases Home Page (NIAID),
National Institutes of Health
http://www.niaid.nih.gov/default.htm


National Institute of Neurological Disorders and Stroke (NINDS)
http://www.ninds.nih.gov/


National Institute of Standards and Technology
http://nist.gov/


National Pork Producers Council
http://www.nppc.org/


Neuromuscular Muscle Autoantibodies
http://www.neuro.wustl.edu/neuromusc...mantibody.html


NIAID Links to Other Sites
http://www.niaid.nih.gov/information/externallinks.htm


Nikon MicroscopyU Confocal Image Gallery - Peyer's Patches
http://www.microscopyu.com/galleries...rspatches.html


NLM's Databases and Electronic Information Sources
http://www.nlm.nih.gov/databases/databases.html


No WorriesT Gluten-Free Bread Mix
http://www.noworriesbread.com/


OMIM - CELIAC DISEASE; CD
http://www.ncbi.nlm.nih.gov/entrez/d....cgi?id=212750


Pathology Teaching Menu
http://medweb.bham.ac.uk/http/depts/.../teachdir.html


Peptide bond - Wikipedia
http://en.wikipedia.org/wiki/Peptide_bond


Periodic table (WebElements)
http://www.webelements.com/


Planet Celiac--the gluten free place to be if you have celiac sprue --
recipes, books and more.
http://www.planetceliac.com/


PorkBoard
http://www.porkboard.org/Home/default.asp


PROWL - Amino Acid Properties
http://prowl.rockefeller.edu/aainfo/contents.htm


PsoriasisNet
http://www.skincarephysicians.com/ps...snet/index.htm


Science of dieting Slim pickings

http://www.nature.com/cgi-taf/DynaPa...28252a_fs.html


Seattle Celiac Support Group
http://www.seattleceliacs.com/


Seborrheic Dermatitis
http://www.aad.org/pamphlets/seborrhe.html


Skindex
http://www.skindex.com/index.html


Society for Mucosal Immunology
http://www.socmucimm.org/


Special Communication - March 8, 1995. Treatment Guidelines for
Hyperthyroidism and Hypothyroid

http://www.ama-assn.org/sci-pubs/jou..._10/sc4291.htm



Special Communication - March 8, 1995. Treatment Guidelines for
Hyperthyroidism and Hypothyroidism. (c) AMA 1996

http://www.ama-assn.org/sci-pubs/jou..._10/sc4291.htm


Specialty Laboratories - clinical reference laboratory contract research
organization
http://www.specialtylabs.com/


StopAllergy.com Ask an Allergist
http://allergist.stopallergy.com/For...lth/Allergist/


Support Groups
http://www.whatnowheat.com/Support%20Groups.htm


Swedish Medical Center Home
http://www.swedish.org/home.asp?Home


The American Gastroenterological Association - Clinical Resources (Patient
Brochures)
http://www.gastro.org/clinicalRes/brochures/ibd.html


The American Gastroenterological Association
http://www.gastro.org/


The Antibody Resource Page educational
http://www.antibodyresource.com/educational.html


The Gluten Free Kitchen
http://gfkitchen.server101.com/


The gluten free message board
http://members2.boardhost.com/gluten...html?999235741


The Great Plains Laboratory, your center of testing and analysis for

Autism,
Pervasive Developmental Disorder (PDD)
http://www.greatplainslaboratory.com/immune.html


The Merck Manual
http://www.merck.com/pubs/


The National Fibromyalgia Association
http://www.fmaware.org/


Thinner - guide to lowcarb weight loss
http://www.thinner.com/


ThirdAge - Health Newsletter - Overlooked, Under-Diagnosed Thyroid Disease
Poses a Challenge
http://www.thirdage.com/news/article...040326-01.html


Thyroid Disease Manager, your source on thyroid disease, hyperthyroidism,
hypothyroidism, thyroiditis,thyroid cancer
http://www.thyroidmanager.org/


Thyroid Disease Symptoms - Hypothyroidism Symptoms
http://www.armourthyroid.com/hypothy.../symptoms.html


TNFA promoter polymorphism and susceptibility to brucellosis - Clin Exp
Immunol, Vol 121, Issue 3, pp. 480-483 (Full Text)

http://www.blackwell-synergy.com/lin....01331.x/full/


Two distinct hemolysins in Trichomonas tenax ATCC 30207 - Oral Microbiol
Immunol, Vol 15, Issue 6, pp. 355-359 (Abstract)

http://www.blackwell-synergy.com/lin...d=bHR8zMK2xU2f

USDA NutrientDatabase
http://www.nal.usda.gov/fnic/foodcomp/search/


Van's Wheat Free Waffles.
http://www.vansintl.com/wheatfree.php


VCUendomysiumResident Cases
http://www.pathology.vcu.edu/WirSelfInst/muscle.html


virus-adeno
http://www.stanford.edu/group/virus/adeno/adeno.html


Voluntary Recall of Taco Bell Taco Shells containing StarLink Corn
http://www.cast-science.org/cast-sci...y/20000925.htm


WAFDO
http://www.wafdo.org/


WebRing hub
http://j.webring.com/hub?ring=celiac


Welcome to Medscape
http://www.medscape.com/px/urlinfo


Welcome to MedWeb
http://medweb.bham.ac.uk/


Welcome to the Gluten Intolerance Group of North America
http://www.gluten.net/


Welcome to the Incredible Edible Egg Website
http://www.aeb.org/


www.patientcenters.com -- Non-Hodgkin's Lymphoma Center -- What are the

NHLs
http://www.patientcenters.com/lymphoma/news/nhl2.html


York Nutritional Laboratories, Inc... Better health begins at home
http://www.yorkallergyusa.com/


[Report] Treatment Algorithms 2000(Table of Contents)
http://www.the-infoshop.com/study/dc...rithm_toc.html




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  #3  
Old April 2nd, 2004, 08:44 AM
Laurence
external usenet poster
 
Posts: n/a
Default What it all does to us.......

What? Wrong place to post this? How many here have IBS? Or similar?


"Sseaott" SseaottATcomcastDOTnet wrote in message
...
P

L

O

N

K
"Laurence" lharris@nwlinkDOTcom wrote in message
...
I am Laurence Harris. I live near Seattle, Washington, USA. I have

Celiac
Disorder, Hashimoto's Thyroiditis, and about five other brushes with
autoimmune disorders. I have a BS degree, have read extensively in
chemistry, biochemistry, and broad ranging medical research topics. I

have
been creating software for computers embedded in medical devices. Most
recently, software to operate a Left Ventricular Assist Device - a heart
pump, which is now successfully operating in at least two humans to good
effect.

After learning about the various medical problems that are associated

with
gluten sensitive enteropathy, I saw a real puzzle staring at me. It

became
a real teaser to me, and the more I learned, the more there seemed to be

to
chase down. Since I have a lot of time available, I have jumped in with
both feet.

I have now spent months researching issues regarding how it is that many
people get AutoImmune Disorders, including Celiac Disease, Thyroiditis

and
a
whole host of others.

The linking of concepts presented here is my own invention, although all

the
underlying technology is from the credible published technical works of

many
others. I have relied only on legitimate sources, mostly medical

journal
articles, although some comes from informational websites put up by

various
professors at universities. Some of my information has come from years

of
reading and study, although I have attempted to find current references

for
most of it since science forges on.

I am inserting a huge list of website references at the end of the text.
They are the resources I used for most of my studies. Some of the

websites
allow you to download entire journal articles as PDFs to store on your

hard
drive. I do that wherever I can, since that works better than viewing

them
in your browser. Unfortunately they are not grouped by topic, nor are

they
in any particular order. To use many of them you must open the website

and
drill down into areas having research papers, journal articles, patient
information and so on. There may be a few that require you to register

to
be able to access the technical content.

The basic picture is that many people, more than have celiac disorder,

have
an immune system that reacts to some parts of the gluten protein in

wheat,
barley and rye. They interpret the protein as "enemy" - an antigen -

just
as though it were a bacterium or virus. Since the immune system reacts

to
foreign objects penetrating the skin, perhaps this explains why.

To follow all this you may want to go to some of the websites and read

on
peptides, immune system, lymphocytes, acute and chronic inflammation.

The Immune System
The human body has wonderful ways of protecting itself. The system of
interacting parts that defends us from invading bacteria, fungi, viruses

and
other foreign matter is collectively referred to as the "immune system".

The
tale we are telling here is one not of allergies (IgE antibodies), but

one
of a different, more insidious kind of immune system activity, (IgA, IgG

and
IgM antibodies).
The immune system includes cells circulating in the blood and lymph and
cells in various other places as well. It includes a variety of cell

types
from those that are self-moving blob-like hunter-killer cells

(macrophages)
to several kinds of miniature chemical factories with some making
destructive toxins and others making specially shaped "antibodies" that
match up to and latch onto the fairly unique cell-surface chemicals used

by
attacking organisms as tools or protective cover.
Blood serum, T-cells, B-cells, macrophages, antibodies, bone marrow,

spleen,
lymphatic system, and various other organs all work together to detect

and
destroy invasion forces. It has taken many millions of hours of research

and
study for us to come as far as we have in our understanding of what

happens
when a bacterium or virus attempts to invade our bodies. And while we

have
a
lot of the picture we are still learning, still searching for missing

pieces
to this magnificent puzzle.

Cells
What we do know is that nearly every type of human cell encases fluids

in
a
cell wall made of a smooth, waterproof, very flexible double-layer of
loosely coupled rod-like molecules we call a plasma membrane. The cell

wall
has various special structures embedded in it to transport materials

across
the barrier. That is how food energy gets in and how waste products get

out.
Inside each cell are a variety of different structures; some are tiny
chemical factories that convert glucose to ready-to-use chemical energy,

and
use that energy for motion, or to create other special chemicals needed

for
the cell's operation. Sometimes the chemicals are to sent out into the

rest
of the human body for use elsewhere.

Cell Identity Flags - Friend or Foe?
But dotted all around on the outside of this smooth cell wall there are
several types of special "identity flags" - specially shaped chemicals

that
are firmly anchored in the cell wall with a large specially shaped part
"waving in the breeze" telling all passing observers who they are -

self.
It
is not really quite that simplistic, but it is actually a combination of
several possible types of identity markers that are recognized by cells

in
the immune system, telling them "Leave me alone! I'm a friend!" And
different types of tissue have slightly differently shaped flags, all

still
self, but not quite all the same. These flags are called Human

Leukocyte
Antigens (HLA) proteins.

Woe be unto cells, like bacteria, who don't know the right combination

of
markers for "friend" - the immune system learns their surface markers,
creates a complimentary shaped pattern and attaches it to special

proteins,
called antibodies, that hook onto the foes' flags and tell the immune

system
"This is a bad guy! Let's take them out!" Once a particular immune

system
cell recognizes an invader it can trigger cells whose job is to make
antibodies to reproduce and make lots more of these useful chemicals.

Immune Responses
Inflammation, created by the fast responders of the immune system, makes

the
area surrounding a detected invasion become porous, or permeable, so

that
antibodies and various immune system cells can "get at" the offenders.

Even
blood vessel walls become rather leaky. This makes surrounding tissues

swell
and turn red.

So the various parts of the immune system work to penetrate or perforate

the
cell wall of an invading organism and make its insides all leak out.

Some
immune system cells pick up the antigens and carry them around with them
like flags, telling other cells about the invader's identity. Some use

the
antibody's matching pattern to latch onto the invading cells' surface
features (antigens) and get up against them to unleash little vesicles

of
destructive chemicals. Others engulf an offender and digest it, or at

least
they carry away indigestible stuff.

Picture these blob-like macrophages, fairly big as blood cells go,

slipping
along in the blood stream and encountering a battle site - they send out

an
amoeba-like tentacle, a pseudopod, and pull themselves over to a marked
offender, then they ooze around it and rejoin on the other side. When it

is
fully engulfed they release chemicals, right up against the bad cell,
similar to chlorine bleach, that chemically take apart the proteins and
lipids that make up the invader's structure. Burp.

Even the lowly virus has chemical patterns that the immune system uses

to
identify them. Virus surface coat chemicals are really tools to make the
virus stick to the surface of a human cell so they can get inside that

cell.
And as a virus drills through the human cell wall it leaves behind

various
parts of its surface coat, sort of embedded in and floating on the human
cell wall. These too are sensed by the immune system and used to

identify
cells that are being taken over by a virus. These human cells then, are
mercilessly destroyed. And the methods work. Takes about two weeks for

the
immune system to detect the invasion, learn the cell-surface markers

left
by
the viruses, make enough antibody factories ( B-Cells and others ), and

do
the search and destroy job. When it is all done, and the antibody

production
shuts down, there are extra of these chemical factories circulating in

the
blood, sort of on standby, in case the same invaders come again. They

would
be able to attack and destroy them before they ever get a foothold

again.
That is learned immunity.

Immunity
Learned immunity is what we try to induce with a vaccine. A vaccine is

just
a whole lot of these cell surface markers without the offending

bacterium
or
virus still attached, or at least if the cell is still there it has,
hopefully, been killed. Seems to work pretty well most of the time. So

we
make a mixture of water with pieces of surface marker protein in it and
inject it into the inside of the body. The immune system sees the

invading
stuff and sets up new antibody manufacturing to fight it off. Since

there
are no real invaders, it is easy to clean up the debris, but the result

is
that the immune system now has standby troops for that particular type

of
invader. It is much better to learn immunity without having to suffer
through a full scale invasion.

The Flags are Proteins
So the cell surface markers are mostly bits of protein, which are really
just interconnected amino acids, which have shapes unique for that kind

of
organism. Amino acids are some of the basic building blocks of the human
body. We get amino acids from eating and digesting meats and plant
materials, although some of them can be made by our own cells. Amino

acids
also serve as a source of food energy when needed. Depending on what

order
you string the amino acids together, and what other chemical bits you

hook
onto the chain at various places, the whole thing folds into a three
dimensional shape. These proteins are sometimes referred to as

"peptides".
(A peptide, then is just a piece of protein.) And shape is what is used

by
antibodies to "recognize" a cell surface marker.

Intestinal Tract
The intestinal tract has a single cell layer, the epithelium that forms
villi - little finger-like projections that are filled with immune

system
cells - lymphocytes - T cells, B cells, macrophages and so on. Below

the
epithelium is something called the submucosa. and under all of it, or

more
properly surrounding all of it is the muscular intestinal wall.

When gluten is present in the intestine, these immune system cells

react,
and cause inflammation. Inflammation makes blood cell walls -

epithelial
tissue - become leaky so that plasma containing antibodies can get at

the
invasion more easily, along with lymphocytes. Unfortunately, the

epithelial
wall of the intestine becomes leakier, too. It is a positive feedback

loop
with inflammation.

And the worse the inflammation, the more of the gluten protein segments

can
get in while other stuff is getting "out" into the digestive tract.

Antibodies
Well, one part of the immune response is to turn on the manufacture of
antibodies - chemicals that physically fit like hand and glove, or plug

and
socket - that match up to the antigens. These little chemical factories

are
in the B cells. And activating a B cell with a matching antibody causes

it
to make antibodies and to replicate.

As long as antigen is being found, the B cells will be told by the T

cells
and macrophages to make antibodies. Or is it the T helper cells that do
this? Any way the replicators get busy and the B cells get busy,

flooding
the blood plasma with antibody chemicals that attach to the antigenic

gluten
protein. Since gluten consumes the antibodies, they have to be replaced
when more gluten comes along.

Fuzzy Logic
Well, B cell replication is designed to not be perfect. The mechanisms

that
transcribe the DNA/RNA stretches that encode antibody peptide sequences

have
a built in randomizer that will occasionally substitute a different

amino
acid into the sequence than was in the original. This apparently serves

the
purpose of making the immune system more adaptable in case the original
match was not quite perfect. And if the new antibody shapes don't match
anything, they are never activated to make antibodies, and do not

replicate
further.

So under a continuous attack from an antigen, such as gluten, the

production
of antibodies is always running, perhaps even in high gear. And along

with
this high rate of activity comes continual varying of the antibody

patterns.

Unfortunately, many people have self-identification cell surface marker
peptides that bear a strong resemblance to gluten protein pieces. So

when
the random variations in antibody shapes just happen to match fairly

closely
with one of these usually protective Human Leukocyte Antigens (HLA), the
particular type of tissue in the human organism that bears that

particular
variation of HLA is suddenly treated as a bad guy, as INVADER, instead

of
SELF. And bang! There goes the thyroid producing cells. Or the Islets

of
Langerhans insulin producing cells. Or any one of a whole lot of other
tissue types.

Endomysial tissue, a connective fibrous material surrounding muscle

cells
apparently is one of the targets of attack, at least as long as gluten

is
revving up the B cells. I'm not sure what the difference between this

sort
of attack that only goes on as long as gluten is being consumed and the
thyroid or insulin cell attacks that seem to continue after gluten is
removed. Perhaps endomysial tissue is only in out-of-the-way places

that
don't typically get visited by T cells or macrophages, and thus only

suffer
when the antibodies are being produced in large amounts to fight off

gluten.

That seems reasonable, since the gluten sets things going by showing up

at
the intestinal inner wall epithelium which is just loaded with

lymphocytes
to keep the fauna and flora of the inside of the intestine from getting
anywhere they shouldn't. And then there is apparently endomysial tissue

in
the submucosa of the intestine? At any rate, the intestinal villi get
destroyed after a long enough time, and since that is where a lot of
digestive enzymes are produced, food doesn't get properly digested, and
since the surface area is smaller, it doesn't get properly absorbed.

So some of these tissue types are continually exposed to lymphocytes,

and
so
cause a sustained attack, while others seem to be typically sheltered,

and
thus don't sustain antibody production when gluten is absent. And then
there is the increased risk of cancer that is associated with untreated

CD.
Only is a problem when the immune system is churning away. Not when all

is
quiescent.

All of this suggests that many people who never get Celiac Disease are

still
experiencing varying degrees of intestinal inflammation from the

consumption
of gluten. And there is a lot known about inflammation and its apparent
linkage to heart trouble, arthritis and a whole lot of other disorders.

And
there are all the autoimmune disorders that seem to be the result of the
churning immune system hitting the wrong combination by accident.

There is even one website by a gastroenterologist suggesting that it

could
be sixty percent or more of mankind that experiences this immune

response
from gluten ingestion.

Various theories have been discussed that involved trigger events to

start
off the attack against self causing an autoimmune disorder. I suspect

that
that is not necessary, although it could play some role in starting some
autoimmune disorders in some people. Apparently H. Pylori bacteria, the
stuff of stomach ulcers, carried by the common housefly, can maintain a
chronic infection in the stomach that does the same sort of job as

gluten
in
the intestine. At least it maintains a constant inflammatory state, and

has
an association with stomach cancers.

And supposedly there is an immune reaction in some people to bakers

yeast.

So what to make of all of this? I think that because there is

legitimate
research published about the increased risk of cancer in untreated

Celiac
Disease (CD) patients, and that we have, in the US, only identified

about
three per cent of those that actually have CD, that one could honestly

make
a statement. about the safety of consuming gluten from wheat, barley or

rye.

================================================== ===========

STATEMENT
"Since the ingestion of gluten from wheat, barley or rye has been
demonstrated, through clinical studies with humans, to cause an elevated
risk of cancer, gluten from wheat, barley and rye should be declared a
CARCINOGENIC SUBSTANCES. To do any less is to doom our children to the
lifetime of slow poisoning that most of us have been experiencing."


================================================== ===========
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================================================== ===========


University of Chicago Hospitals Celiac disease is far more common than
thought
http://www.uchospitals.edu/news/2003...210-celiac.php



Food Allergy & Anaphylaxis Network
http://www.foodallergy.org/


PBC Lab - Dr. Gershwin
http://internalmedicine.ucdmc.ucdavi...ology/PBC_Lab/


search engine for gluten free friendly inns, bed and breakfasts, and

small
hotels
http://www.1-888-inn-seek.com/GFinns.htm


AAAAI - American Academy of Allergy Asthma and Immunology -

www.aaaai.org
http://www.aaaai.org/


About.com http--www.autoimmunebook.com


http://thyroid.about.com/gi/dynamic/...munebook.c om


// Acute Inflammation UK BHAM
// http://medweb.bham.ac.uk/http/mod/3/1/a/acute.html


// adam.com Encyclopedia Disease Reference
// http://oso.adam.com/


Adenoviruses
http://www.tulane.edu/~dmsander/WWW/...noviruses.html


AllRefer Health - Autoimmune Disorders
http://health.allrefer.com/health/au...ders-info.html


AllRefer Health - Celiac Disease - Sprue Support Groups
http://health.allrefer.com/health/ce...e-support.html


Alt.Support.Thyroid Newsgroup Website
http://www.altsupportthyroid.org/


American Academy of Dermatology
http://www.aad.org/

American Academy of Dermatology
http://www.skincarephysicians.com/eczemanet/whatIs.html

American Association of Immunologists
http://www.aai.org/

American Association of Immunologists Journal
http://www.jimmunol.org/


American Peptide Society
http://www.ampepsoc.org/


American Pharmaceutical Online References
http://www.medicalresourcesusa.com/pharmrefguide.htm



American Thyroid Association
http://www.thyroid.org/


Antigen Receptor Diversity


http://users.rcn.com/jkimball.ma.ult...Diversity.html


Applied Biosystems
http://www.appliedbiosystems.com/


Archives of
http://maelstrom.stjohns.edu/archives/celiac.html


Aspiration Biopsy of the Thyroid
http://www.thyroidfoundation.org/aspiration.htm


Asthma and Allergy Information and Research (AAIR) Home Page
http://www.users.globalnet.co.uk/~aair/


Atkins Diet & Low Carbohydrate Weight-Loss Support - Low Carb Diet

Recipes
&
Resources
http://www.lowcarb.ca/


Atkins Nutritionals Home
http://atkinscenter.com/dev/


AuthenticFoods
http://www.authenticfoods.com/


Autoimmune Disorders
http://www.thedoctorsdoctor.com/dise..._disorders.htm


Autoimmunity AARDA American Autoimmune Related Diseases Association
http://www.aarda.org/


B Cells and T Cells

http://users.rcn.com/jkimball.ma.ult...nd_Tcells.html


BBC - Science & Nature - Horizon - The Atkins Diet
http://www.bbc.co.uk/science/horizon...instrans.shtml


Canadian Celiac Association
http://www.celiac.ca/englishcca.html


Candida, Fibromyalgia, IBS, Celiac, Colitis, yeast infections, thrush,
sinusitis, leaky gut syndrome,etc
http://www.candidafree.net/pages/1/index.htm


Candida
http://www.candidafree.net/pages/1/index.htm


Carrageenan, Food Resource [http--food.oregonstate.edu-], Oregon State
University, Corvallis, OR
http://food.oregonstate.edu/gums/carr.html


Case Study A 37-Year-Old Man With Type 1 Diabetes, Vomiting, and

Diarrhea
http://journal.diabetes.org/clinical...1999/pg188.htm


CDC Health Topic Foodborne Illnesses
http://www.cdc.gov/health/foodill.htm


CELIAC (Celiac-Coeliac Wheat-Gluten-Free List)
http://www.enabling.org/ia/celiac/


Celiac Disease - DrGreene.com - caring for the next generation
http://www.drgreene.com/21_1522.html


Celiac Disease -- eCureMe.com
http://www.ecureme.com/emyhealth/Ped...ac_Disease.asp


Celiac disease and hypoparathyroidism cross-reaction of endomysial
antibodies with parathyroid tissue.


http://www.pubmedcentral.nih.gov/art...ype=abstrac t


Celiac Disease Foundation
http://www.celiac.org/


Celiac Disease NDDIC
http://digestive.niddk.nih.gov/ddise...liac/index.htm


Celiac Disease
http://digestive.niddk.nih.gov/ddise...liac/index.htm


Celiac Resources for Physicians
http://www.uams.edu/celiac/


Celiac Sprue Research Foundation
http://www.celiacsprue.org/


Celiac.com (Diagnosis & Treatment of Celiac Disease A Gluten-Free Diet)


http://www.celiac.com/cgi-bin/webc.c...37103580146.6d


CELLS alive!
http://www.cellsalive.com/index.htm


Center For Celiac Research
http://www.celiaccenter.org/


Center for Science in the Public Interest
http://cspinet.org/


ChemQuik® - Free MSDS MSDS Service Mobile MSDS Chemical Inventory

AOS
http://www.chemquik.com/site/cq/welcome.asp


Chronic inflammatory cells


http://medweb.bham.ac.uk/http/depts/...F/infcell.html


Clan Thompson's Celiac Site
http://www.clanthompson.com/index.php3


Clinical Immunology Society
http://www.clinimmsoc.org/


Clonal Selection


http://users.rcn.com/jkimball.ma.ult...Selection.html


coeliac disease-gluten free info & message board (mainly UK)
http://coeliac.info/


Delphi Celiac Disease On-Line Support Group


http://forums.delphiforums.com/n/mai...li ac%2Fstart


Detecting Celiac Disease in Your Patients - March 1, 1998 - American

Academy
of Family Physicians
http://www.aafp.org/afp/980301ap/pruessn.html


Diabetes Care The High Prevalence of Autoantibodies to Tissue
Transglutaminase in First-Degree Relatives
http://www.findarticles.com/cf_dls/m.../article.jhtml


Dietary Soluble Fiber Resource
http://www.gy.com/index.htm


Digestion and Balance
http://www.medhelp.org/forums/gastro...es/35622a.html


Electronic Code of Federal Regulations
http://ecfr.gpoaccess.gov/


EnteroLab
http://www.enterolab.com/


Entrez-PubMed
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi


eosinophils
http://www.nursing.ucla.edu/userpage...c/eosinoph.htm


FDA-CFSAN Food Labeling Overview
http://www.cfsan.fda.gov/label.html


FDA-CFSAN Information about Food Allergies
http://vm.cfsan.fda.gov/~dms/wh-alrgy.html


Food and Drug Administration Home Page
http://www.fda.gov/


Food Safety and Inspection Service Home Page
http://www.fsis.usda.gov/


foodallergynetwork.com
http://foodallergynetwork.com/


FoodNet (CDC)
http://www.cdc.gov/foodnet/


Gastroenterology


http://www2.gastrojournal.org/script...r=home&id=gast


Gluten Free Brewing Project
http://www.fortunecity.com/boozers/b...eer/gfbeer.htm


Gluten Free Medications
http://www.glutenfreedrugs.com/


Gluten Intolerance Group of North America
http://www.gluten.net/


Gluten-Free Trading Company Home Page
http://www.gluten-free.tc/


Glycogen Metabolism
http://www.indstate.edu/thcme/mwking/glycogen.html


GMA, Food Allergy Alliance Develop Easy to Understand Labeling

Guidelines
GMA News Release 5-31-01
http://www.gmabrands.com/news/docs/N...cfm?DocID=767&


Google Search r-s medical
http://www.google.com/search?hl=en&i...&q=r-s+medical


Grain Inspection
http://www.usda.gov/gipsa/


GrainPuritySampling
http://www.usda.gov/gipsa/biotech/sample2.htm


GSDL Instestinal Permeability Assessment Application Guide
http://www.gsdl.com/assessments/ip/appguide/


Guar, Food Resource [http--food.oregonstate.edu-], Oregon State

University,
Corvallis, OR
http://food.oregonstate.edu/gums/guar.html


Gum Arabic, Food Resource [http--food.oregonstate.edu-], Oregon State
University, Corvallis, OR
http://food.oregonstate.edu/gums/arabic.html


HealthScout
http://www.healthscout.com/


Hospital Practice Recognizing Thyrotoxicosis
http://www.hosppract.com/issues/1999/05/dmmmazz.htm


How Antibodies are Produced
http://www.cellsalive.com/antibody.htm


http--www.cvm.okstate.edu-instruction-kocan-vpar5333-5333iid.htm
http://www.cvm.okstate.edu/instructi...33/5333iid.htm


http--www.inel.gov-x-web-other-framed.shtmlhttp--www.sisweb.com
http://www.inel.gov/x-web/other/fram...www.sisweb.com


http--www.nal.usda.gov-fnic-foodcomp-search-
http://www.nal.usda.gov/fnic/foodcomp/search/


http--www.whatnowheat.com-
http://www.whatnowheat.com/


Hypothyroidism and the TSH Reference Range - Alt.Support.Thyroid

Newsgroup
Website
http://www.altsupportthyroid.org/tsh/tshmedrefs1.php


IBM Life Sciences Web Lecture Series


http://www.ibmweblectureservices.iho...rigin=103ALE3S


IMMUNE DEFICIENCY FOUNDATION
http://www.primaryimmune.org/


Immune Recognition of the Mycobacterial Cell Wall
http://www.eurekah.com/abstract.php?...id=69&catid=73


Immune Tolerance Network - Industry Partnerships
http://www.immunetolerance.org/industry/


Immune Tolerance Network
http://www.immunetolerance.org/


Immune Web -- Support and Information Network
http://www.immuneweb.org/


Immunology of Diabetes Society Home Page
http://www.idsoc.org/


IMMUNOSCIENCES LAB.
http://www.immuno-sci-lab.com/2003_cat_page64.htm


Inflammation Long-Term Effects, from Arthritis.com
http://www.arthritis.com/1_5.asp


Inflammation Research Association
http://www.inflammationresearch.org/


Inflammation The Battle Within
http://arthritis.about.com/cs/arthge...flammation.htm


Inflammation, Heart Disease and Stroke The Role of C-Reactive Protein
http://www.americanheart.org/present...dentifier=4648


INFOMED ONLINE
http://www.infomed.org/



International Society for Mountain Medicine
http://www.ismmed.org/



Is Subclinical Gluten Intolerance-Celiac Disease Sabotaging Your

Health -
Thyroid Disease Information
http://www.thyroid-info.com/articles/glutenceliac.htm


Kaili's Kitchen
http://www.wheatlessinseattle.com/


Kimball's Biology Pages
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/


Lab Tests Online Welcome!
http://www.labtestsonline.org/


LAMISIL - Nail fungus treatment, tips for healthy nails
http://www.lamisil.com/index.jsp?checked=y


Legacy Laboratory Services - Legacy Health System - Portland, OR

http://www.legacyhealth.org/healthca...php?testid=387


Lipids Online - Educational Resources in Atherosclerosis and Coronary

Heart
Disease
http://www.lipidsonline.org/


Low Carb Research, Atkins Diet Research, Low Carb Diet Research
http://www.lowcarbresearch.org/lcr/results.asp


LOW CARBOHYDRATE RECIPES
http://www.carb-lite.au.com/fdbreakfast.html


Lymphoma Patients Information Resources
http://www.lymphoma.org.uk/support/i...on/Default.htm


Lymphoma Research Foundation Learning About Lymphoma
http://www.lymphoma.org/site/PageSer...ename=learning


Lymphoma Research Foundation
http://www.lymphoma.org/site/PageSer...gename=Seattle


Macular Pucker
http://www.vrmny.com/ERM.htm


Making Your Voice Heard at FDA How to Comment on Proposed Regulations

and
Submit Petitions
http://www.fda.gov/opacom/backgrounders/voice.html


MayoClinic.com - Medical and health information for a healthier life

from
Mayo Clinic
http://www.mayoclinic.com/invoke.cfm?id=DS00319


MDDI
http://www.devicelink.com/mddi/


MedicineNetInformation on Celiac disease
http://www.medicinenet.com/Celiac_Disease/article.htm


MedlinePlus Celiac Disease
http://www.nlm.nih.gov/medlineplus/celiacdisease.html


MEDLINEplus Health Information from the National Library of Medicine
http://www.nlm.nih.gov/medlineplus/medlineplus.html


MedlinePlus Medical Encyclopedia Autoimmune disorders
http://www.nlm.nih.gov/medlineplus/e...cle/000816.htm


Metabolic Pathways of Biochemistry
http://www.gwu.edu/~mpb/


Molecular Immunology
http://www.mi.interhealth.info/


Monterey Bay Aquarium Seafood Watch Program - Regional Seafood Watch

Cards
http://www.mbayaq.org/cr/cr_seafoodw...w_regional.asp


Muscle Biopsy
http://www.neuro.wustl.edu/neuromusc...ab/mbiopsy.htm


National Institute of Allergy and Infectious Diseases Home Page (NIAID),
National Institutes of Health
http://www.niaid.nih.gov/default.htm


National Institute of Neurological Disorders and Stroke (NINDS)
http://www.ninds.nih.gov/


National Institute of Standards and Technology
http://nist.gov/


National Pork Producers Council
http://www.nppc.org/


Neuromuscular Muscle Autoantibodies
http://www.neuro.wustl.edu/neuromusc...mantibody.html


NIAID Links to Other Sites
http://www.niaid.nih.gov/information/externallinks.htm


Nikon MicroscopyU Confocal Image Gallery - Peyer's Patches
http://www.microscopyu.com/galleries...rspatches.html


NLM's Databases and Electronic Information Sources
http://www.nlm.nih.gov/databases/databases.html


No WorriesT Gluten-Free Bread Mix
http://www.noworriesbread.com/


OMIM - CELIAC DISEASE; CD
http://www.ncbi.nlm.nih.gov/entrez/d....cgi?id=212750


Pathology Teaching Menu
http://medweb.bham.ac.uk/http/depts/.../teachdir.html


Peptide bond - Wikipedia
http://en.wikipedia.org/wiki/Peptide_bond


Periodic table (WebElements)
http://www.webelements.com/


Planet Celiac--the gluten free place to be if you have celiac sprue --
recipes, books and more.
http://www.planetceliac.com/


PorkBoard
http://www.porkboard.org/Home/default.asp


PROWL - Amino Acid Properties
http://prowl.rockefeller.edu/aainfo/contents.htm


PsoriasisNet
http://www.skincarephysicians.com/ps...snet/index.htm


Science of dieting Slim pickings


http://www.nature.com/cgi-taf/DynaPa...28252a_fs.html


Seattle Celiac Support Group
http://www.seattleceliacs.com/


Seborrheic Dermatitis
http://www.aad.org/pamphlets/seborrhe.html


Skindex
http://www.skindex.com/index.html


Society for Mucosal Immunology
http://www.socmucimm.org/


Special Communication - March 8, 1995. Treatment Guidelines for
Hyperthyroidism and Hypothyroid


http://www.ama-assn.org/sci-pubs/jou..._10/sc4291.htm



Special Communication - March 8, 1995. Treatment Guidelines for
Hyperthyroidism and Hypothyroidism. (c) AMA 1996


http://www.ama-assn.org/sci-pubs/jou..._10/sc4291.htm


Specialty Laboratories - clinical reference laboratory contract research
organization
http://www.specialtylabs.com/


StopAllergy.com Ask an Allergist
http://allergist.stopallergy.com/For...lth/Allergist/


Support Groups
http://www.whatnowheat.com/Support%20Groups.htm


Swedish Medical Center Home
http://www.swedish.org/home.asp?Home


The American Gastroenterological Association - Clinical Resources

(Patient
Brochures)
http://www.gastro.org/clinicalRes/brochures/ibd.html


The American Gastroenterological Association
http://www.gastro.org/


The Antibody Resource Page educational
http://www.antibodyresource.com/educational.html


The Gluten Free Kitchen
http://gfkitchen.server101.com/


The gluten free message board
http://members2.boardhost.com/gluten...html?999235741


The Great Plains Laboratory, your center of testing and analysis for

Autism,
Pervasive Developmental Disorder (PDD)
http://www.greatplainslaboratory.com/immune.html


The Merck Manual
http://www.merck.com/pubs/


The National Fibromyalgia Association
http://www.fmaware.org/


Thinner - guide to lowcarb weight loss
http://www.thinner.com/


ThirdAge - Health Newsletter - Overlooked, Under-Diagnosed Thyroid

Disease
Poses a Challenge
http://www.thirdage.com/news/article...040326-01.html


Thyroid Disease Manager, your source on thyroid disease,

hyperthyroidism,
hypothyroidism, thyroiditis,thyroid cancer
http://www.thyroidmanager.org/


Thyroid Disease Symptoms - Hypothyroidism Symptoms
http://www.armourthyroid.com/hypothy.../symptoms.html


TNFA promoter polymorphism and susceptibility to brucellosis - Clin Exp
Immunol, Vol 121, Issue 3, pp. 480-483 (Full Text)


http://www.blackwell-synergy.com/lin....01331.x/full/


Two distinct hemolysins in Trichomonas tenax ATCC 30207 - Oral Microbiol
Immunol, Vol 15, Issue 6, pp. 355-359 (Abstract)


http://www.blackwell-synergy.com/lin...d=bHR8zMK2xU2f

USDA NutrientDatabase
http://www.nal.usda.gov/fnic/foodcomp/search/


Van's Wheat Free Waffles.
http://www.vansintl.com/wheatfree.php


VCUendomysiumResident Cases
http://www.pathology.vcu.edu/WirSelfInst/muscle.html


virus-adeno
http://www.stanford.edu/group/virus/adeno/adeno.html


Voluntary Recall of Taco Bell Taco Shells containing StarLink Corn
http://www.cast-science.org/cast-sci...y/20000925.htm


WAFDO
http://www.wafdo.org/


WebRing hub
http://j.webring.com/hub?ring=celiac


Welcome to Medscape
http://www.medscape.com/px/urlinfo


Welcome to MedWeb
http://medweb.bham.ac.uk/


Welcome to the Gluten Intolerance Group of North America
http://www.gluten.net/


Welcome to the Incredible Edible Egg Website
http://www.aeb.org/


www.patientcenters.com -- Non-Hodgkin's Lymphoma Center -- What are the

NHLs
http://www.patientcenters.com/lymphoma/news/nhl2.html


York Nutritional Laboratories, Inc... Better health begins at home
http://www.yorkallergyusa.com/


[Report] Treatment Algorithms 2000(Table of Contents)
http://www.the-infoshop.com/study/dc...rithm_toc.html




================================================== ===========



















  #4  
Old April 2nd, 2004, 10:24 AM
JJ
external usenet poster
 
Posts: n/a
Default What it all does to us.......

Laurence wrote:
What? Wrong place to post this? How many here have IBS?
Or similar?

Personally, I would ignore the first response you received.

I'll take the time to read and understand what you have
posted and the assertions contained therein. I'm kind of
looking forward to the meaningful responses you might get
from others on this write-up.

--
JJ.


  #5  
Old April 2nd, 2004, 10:26 AM
TavliGal
external usenet poster
 
Posts: n/a
Default What it all does to us.......

Laurence wrote:
What? Wrong place to post this? How many here have IBS? Or
similar?

Don't worry about him Laurence, he's just a kid and a twit to boot. He
"plonks" everyone he doesn't agree with or likes.
I've heard of a few people who have IBS around here.

Monica
--
Started 01/20/04
362/322.4/250
__________________________________________________ ______
"Watch what people are cynical about, and one can often discover
what they lack. - Harry Emerson Fosdick




---
Outgoing mail is certified Virus Free.
Checked by AVG anti-virus system (http://www.grisoft.com).
Version: 6.0.644 / Virus Database: 412 - Release Date: 3/26/04


  #6  
Old April 2nd, 2004, 10:26 AM
Logorrhea
external usenet poster
 
Posts: n/a
Default What it all does to us.......


"Sseaott" SseaottATcomcastDOTnet wrote in message
...
P

L

O

N

K


So, why not snip the OP's 35kb of drivel, rather than steal bandwidth by
repeating it? Sheesh!


  #7  
Old April 2nd, 2004, 11:47 AM
Sseaott
external usenet poster
 
Posts: n/a
Default What it all does to us.......

I'm a kid?

Nice to know you know who I am when you don't know me lol.

This is a newsgroup about carbs, NOT IMBS!

ONCE AGAIN

P
L
O
N
K
!


"TavliGal" wrote in message
news:7labc.10560$oR5.813@pd7tw3no...
Laurence wrote:
What? Wrong place to post this? How many here have IBS? Or
similar?

Don't worry about him Laurence, he's just a kid and a twit to boot. He
"plonks" everyone he doesn't agree with or likes.
I've heard of a few people who have IBS around here.

Monica
--
Started 01/20/04
362/322.4/250
__________________________________________________ ______
"Watch what people are cynical about, and one can often discover
what they lack. - Harry Emerson Fosdick




---
Outgoing mail is certified Virus Free.
Checked by AVG anti-virus system (http://www.grisoft.com).
Version: 6.0.644 / Virus Database: 412 - Release Date: 3/26/04




  #8  
Old April 2nd, 2004, 11:48 AM
Sseaott
external usenet poster
 
Posts: n/a
Default What it all does to us.......

Personally, if I were you, which I'm not, THANK GOD!...I would go order a
Pizza...

P
L
O
N
K
!


"JJ" wrote in message news:Qiabc.58812$w54.368475@attbi_s01...
Laurence wrote:
What? Wrong place to post this? How many here have IBS?
Or similar?

Personally, I would ignore the first response you received.

I'll take the time to read and understand what you have
posted and the assertions contained therein. I'm kind of
looking forward to the meaningful responses you might get
from others on this write-up.

--
JJ.




  #9  
Old April 2nd, 2004, 11:49 AM
Sseaott
external usenet poster
 
Posts: n/a
Default What it all does to us.......

This is a newsgroup about LOW CARBS, NOT IBS!

Now go on you troll, find your way home.


"Laurence" lharris@nwlinkDOTcom wrote in message
...
What? Wrong place to post this? How many here have IBS? Or similar?


"Sseaott" SseaottATcomcastDOTnet wrote in message
...
P

L

O

N

K
"Laurence" lharris@nwlinkDOTcom wrote in message
...
I am Laurence Harris. I live near Seattle, Washington, USA. I have

Celiac
Disorder, Hashimoto's Thyroiditis, and about five other brushes with
autoimmune disorders. I have a BS degree, have read extensively in
chemistry, biochemistry, and broad ranging medical research topics. I

have
been creating software for computers embedded in medical devices.

Most
recently, software to operate a Left Ventricular Assist Device - a

heart
pump, which is now successfully operating in at least two humans to

good
effect.

After learning about the various medical problems that are associated

with
gluten sensitive enteropathy, I saw a real puzzle staring at me. It

became
a real teaser to me, and the more I learned, the more there seemed to

be
to
chase down. Since I have a lot of time available, I have jumped in

with
both feet.

I have now spent months researching issues regarding how it is that

many
people get AutoImmune Disorders, including Celiac Disease, Thyroiditis

and
a
whole host of others.

The linking of concepts presented here is my own invention, although

all
the
underlying technology is from the credible published technical works

of
many
others. I have relied only on legitimate sources, mostly medical

journal
articles, although some comes from informational websites put up by

various
professors at universities. Some of my information has come from

years
of
reading and study, although I have attempted to find current

references
for
most of it since science forges on.

I am inserting a huge list of website references at the end of the

text.
They are the resources I used for most of my studies. Some of the

websites
allow you to download entire journal articles as PDFs to store on your

hard
drive. I do that wherever I can, since that works better than viewing

them
in your browser. Unfortunately they are not grouped by topic, nor are

they
in any particular order. To use many of them you must open the

website
and
drill down into areas having research papers, journal articles,

patient
information and so on. There may be a few that require you to

register
to
be able to access the technical content.

The basic picture is that many people, more than have celiac disorder,

have
an immune system that reacts to some parts of the gluten protein in

wheat,
barley and rye. They interpret the protein as "enemy" - an antigen -

just
as though it were a bacterium or virus. Since the immune system

reacts
to
foreign objects penetrating the skin, perhaps this explains why.

To follow all this you may want to go to some of the websites and read

on
peptides, immune system, lymphocytes, acute and chronic inflammation.

The Immune System
The human body has wonderful ways of protecting itself. The system of
interacting parts that defends us from invading bacteria, fungi,

viruses
and
other foreign matter is collectively referred to as the "immune

system".
The
tale we are telling here is one not of allergies (IgE antibodies), but

one
of a different, more insidious kind of immune system activity, (IgA,

IgG
and
IgM antibodies).
The immune system includes cells circulating in the blood and lymph

and
cells in various other places as well. It includes a variety of cell

types
from those that are self-moving blob-like hunter-killer cells

(macrophages)
to several kinds of miniature chemical factories with some making
destructive toxins and others making specially shaped "antibodies"

that
match up to and latch onto the fairly unique cell-surface chemicals

used
by
attacking organisms as tools or protective cover.
Blood serum, T-cells, B-cells, macrophages, antibodies, bone marrow,

spleen,
lymphatic system, and various other organs all work together to detect

and
destroy invasion forces. It has taken many millions of hours of

research
and
study for us to come as far as we have in our understanding of what

happens
when a bacterium or virus attempts to invade our bodies. And while we

have
a
lot of the picture we are still learning, still searching for missing

pieces
to this magnificent puzzle.

Cells
What we do know is that nearly every type of human cell encases fluids

in
a
cell wall made of a smooth, waterproof, very flexible double-layer of
loosely coupled rod-like molecules we call a plasma membrane. The cell

wall
has various special structures embedded in it to transport materials

across
the barrier. That is how food energy gets in and how waste products

get
out.
Inside each cell are a variety of different structures; some are tiny
chemical factories that convert glucose to ready-to-use chemical

energy,
and
use that energy for motion, or to create other special chemicals

needed
for
the cell's operation. Sometimes the chemicals are to sent out into the

rest
of the human body for use elsewhere.

Cell Identity Flags - Friend or Foe?
But dotted all around on the outside of this smooth cell wall there

are
several types of special "identity flags" - specially shaped chemicals

that
are firmly anchored in the cell wall with a large specially shaped

part
"waving in the breeze" telling all passing observers who they are -

self.
It
is not really quite that simplistic, but it is actually a combination

of
several possible types of identity markers that are recognized by

cells
in
the immune system, telling them "Leave me alone! I'm a friend!" And
different types of tissue have slightly differently shaped flags, all

still
self, but not quite all the same. These flags are called Human

Leukocyte
Antigens (HLA) proteins.

Woe be unto cells, like bacteria, who don't know the right combination

of
markers for "friend" - the immune system learns their surface markers,
creates a complimentary shaped pattern and attaches it to special

proteins,
called antibodies, that hook onto the foes' flags and tell the immune

system
"This is a bad guy! Let's take them out!" Once a particular immune

system
cell recognizes an invader it can trigger cells whose job is to make
antibodies to reproduce and make lots more of these useful chemicals.

Immune Responses
Inflammation, created by the fast responders of the immune system,

makes
the
area surrounding a detected invasion become porous, or permeable, so

that
antibodies and various immune system cells can "get at" the offenders.

Even
blood vessel walls become rather leaky. This makes surrounding tissues

swell
and turn red.

So the various parts of the immune system work to penetrate or

perforate
the
cell wall of an invading organism and make its insides all leak out.

Some
immune system cells pick up the antigens and carry them around with

them
like flags, telling other cells about the invader's identity. Some use

the
antibody's matching pattern to latch onto the invading cells' surface
features (antigens) and get up against them to unleash little vesicles

of
destructive chemicals. Others engulf an offender and digest it, or at

least
they carry away indigestible stuff.

Picture these blob-like macrophages, fairly big as blood cells go,

slipping
along in the blood stream and encountering a battle site - they send

out
an
amoeba-like tentacle, a pseudopod, and pull themselves over to a

marked
offender, then they ooze around it and rejoin on the other side. When

it
is
fully engulfed they release chemicals, right up against the bad cell,
similar to chlorine bleach, that chemically take apart the proteins

and
lipids that make up the invader's structure. Burp.

Even the lowly virus has chemical patterns that the immune system uses

to
identify them. Virus surface coat chemicals are really tools to make

the
virus stick to the surface of a human cell so they can get inside that

cell.
And as a virus drills through the human cell wall it leaves behind

various
parts of its surface coat, sort of embedded in and floating on the

human
cell wall. These too are sensed by the immune system and used to

identify
cells that are being taken over by a virus. These human cells then,

are
mercilessly destroyed. And the methods work. Takes about two weeks for

the
immune system to detect the invasion, learn the cell-surface markers

left
by
the viruses, make enough antibody factories ( B-Cells and others ),

and
do
the search and destroy job. When it is all done, and the antibody

production
shuts down, there are extra of these chemical factories circulating in

the
blood, sort of on standby, in case the same invaders come again. They

would
be able to attack and destroy them before they ever get a foothold

again.
That is learned immunity.

Immunity
Learned immunity is what we try to induce with a vaccine. A vaccine is

just
a whole lot of these cell surface markers without the offending

bacterium
or
virus still attached, or at least if the cell is still there it has,
hopefully, been killed. Seems to work pretty well most of the time. So

we
make a mixture of water with pieces of surface marker protein in it

and
inject it into the inside of the body. The immune system sees the

invading
stuff and sets up new antibody manufacturing to fight it off. Since

there
are no real invaders, it is easy to clean up the debris, but the

result
is
that the immune system now has standby troops for that particular type

of
invader. It is much better to learn immunity without having to suffer
through a full scale invasion.

The Flags are Proteins
So the cell surface markers are mostly bits of protein, which are

really
just interconnected amino acids, which have shapes unique for that

kind
of
organism. Amino acids are some of the basic building blocks of the

human
body. We get amino acids from eating and digesting meats and plant
materials, although some of them can be made by our own cells. Amino

acids
also serve as a source of food energy when needed. Depending on what

order
you string the amino acids together, and what other chemical bits you

hook
onto the chain at various places, the whole thing folds into a three
dimensional shape. These proteins are sometimes referred to as

"peptides".
(A peptide, then is just a piece of protein.) And shape is what is

used
by
antibodies to "recognize" a cell surface marker.

Intestinal Tract
The intestinal tract has a single cell layer, the epithelium that

forms
villi - little finger-like projections that are filled with immune

system
cells - lymphocytes - T cells, B cells, macrophages and so on. Below

the
epithelium is something called the submucosa. and under all of it, or

more
properly surrounding all of it is the muscular intestinal wall.

When gluten is present in the intestine, these immune system cells

react,
and cause inflammation. Inflammation makes blood cell walls -

epithelial
tissue - become leaky so that plasma containing antibodies can get at

the
invasion more easily, along with lymphocytes. Unfortunately, the

epithelial
wall of the intestine becomes leakier, too. It is a positive feedback

loop
with inflammation.

And the worse the inflammation, the more of the gluten protein

segments
can
get in while other stuff is getting "out" into the digestive tract.

Antibodies
Well, one part of the immune response is to turn on the manufacture of
antibodies - chemicals that physically fit like hand and glove, or

plug
and
socket - that match up to the antigens. These little chemical

factories
are
in the B cells. And activating a B cell with a matching antibody

causes
it
to make antibodies and to replicate.

As long as antigen is being found, the B cells will be told by the T

cells
and macrophages to make antibodies. Or is it the T helper cells that

do
this? Any way the replicators get busy and the B cells get busy,

flooding
the blood plasma with antibody chemicals that attach to the antigenic

gluten
protein. Since gluten consumes the antibodies, they have to be

replaced
when more gluten comes along.

Fuzzy Logic
Well, B cell replication is designed to not be perfect. The

mechanisms
that
transcribe the DNA/RNA stretches that encode antibody peptide

sequences
have
a built in randomizer that will occasionally substitute a different

amino
acid into the sequence than was in the original. This apparently

serves
the
purpose of making the immune system more adaptable in case the

original
match was not quite perfect. And if the new antibody shapes don't

match
anything, they are never activated to make antibodies, and do not

replicate
further.

So under a continuous attack from an antigen, such as gluten, the

production
of antibodies is always running, perhaps even in high gear. And along

with
this high rate of activity comes continual varying of the antibody

patterns.

Unfortunately, many people have self-identification cell surface

marker
peptides that bear a strong resemblance to gluten protein pieces. So

when
the random variations in antibody shapes just happen to match fairly

closely
with one of these usually protective Human Leukocyte Antigens (HLA),

the
particular type of tissue in the human organism that bears that

particular
variation of HLA is suddenly treated as a bad guy, as INVADER, instead

of
SELF. And bang! There goes the thyroid producing cells. Or the

Islets
of
Langerhans insulin producing cells. Or any one of a whole lot of

other
tissue types.

Endomysial tissue, a connective fibrous material surrounding muscle

cells
apparently is one of the targets of attack, at least as long as gluten

is
revving up the B cells. I'm not sure what the difference between this

sort
of attack that only goes on as long as gluten is being consumed and

the
thyroid or insulin cell attacks that seem to continue after gluten is
removed. Perhaps endomysial tissue is only in out-of-the-way places

that
don't typically get visited by T cells or macrophages, and thus only

suffer
when the antibodies are being produced in large amounts to fight off

gluten.

That seems reasonable, since the gluten sets things going by showing

up
at
the intestinal inner wall epithelium which is just loaded with

lymphocytes
to keep the fauna and flora of the inside of the intestine from

getting
anywhere they shouldn't. And then there is apparently endomysial

tissue
in
the submucosa of the intestine? At any rate, the intestinal villi get
destroyed after a long enough time, and since that is where a lot of
digestive enzymes are produced, food doesn't get properly digested,

and
since the surface area is smaller, it doesn't get properly absorbed.

So some of these tissue types are continually exposed to lymphocytes,

and
so
cause a sustained attack, while others seem to be typically sheltered,

and
thus don't sustain antibody production when gluten is absent. And

then
there is the increased risk of cancer that is associated with

untreated
CD.
Only is a problem when the immune system is churning away. Not when

all
is
quiescent.

All of this suggests that many people who never get Celiac Disease are

still
experiencing varying degrees of intestinal inflammation from the

consumption
of gluten. And there is a lot known about inflammation and its

apparent
linkage to heart trouble, arthritis and a whole lot of other

disorders.
And
there are all the autoimmune disorders that seem to be the result of

the
churning immune system hitting the wrong combination by accident.

There is even one website by a gastroenterologist suggesting that it

could
be sixty percent or more of mankind that experiences this immune

response
from gluten ingestion.

Various theories have been discussed that involved trigger events to

start
off the attack against self causing an autoimmune disorder. I suspect

that
that is not necessary, although it could play some role in starting

some
autoimmune disorders in some people. Apparently H. Pylori bacteria,

the
stuff of stomach ulcers, carried by the common housefly, can maintain

a
chronic infection in the stomach that does the same sort of job as

gluten
in
the intestine. At least it maintains a constant inflammatory state,

and
has
an association with stomach cancers.

And supposedly there is an immune reaction in some people to bakers

yeast.

So what to make of all of this? I think that because there is

legitimate
research published about the increased risk of cancer in untreated

Celiac
Disease (CD) patients, and that we have, in the US, only identified

about
three per cent of those that actually have CD, that one could honestly

make
a statement. about the safety of consuming gluten from wheat, barley

or
rye.

================================================== ===========

STATEMENT
"Since the ingestion of gluten from wheat, barley or rye has been
demonstrated, through clinical studies with humans, to cause an

elevated
risk of cancer, gluten from wheat, barley and rye should be declared

a
CARCINOGENIC SUBSTANCES. To do any less is to doom our children to

the
lifetime of slow poisoning that most of us have been experiencing."


================================================== ===========
================================================== ===========
================================================== ===========
================================================== ===========
================================================== ===========


University of Chicago Hospitals Celiac disease is far more common than
thought
http://www.uchospitals.edu/news/2003...210-celiac.php



Food Allergy & Anaphylaxis Network
http://www.foodallergy.org/


PBC Lab - Dr. Gershwin
http://internalmedicine.ucdmc.ucdavi...ology/PBC_Lab/


search engine for gluten free friendly inns, bed and breakfasts, and

small
hotels
http://www.1-888-inn-seek.com/GFinns.htm


AAAAI - American Academy of Allergy Asthma and Immunology -

www.aaaai.org
http://www.aaaai.org/


About.com http--www.autoimmunebook.com



http://thyroid.about.com/gi/dynamic/...munebook.c om


// Acute Inflammation UK BHAM
// http://medweb.bham.ac.uk/http/mod/3/1/a/acute.html


// adam.com Encyclopedia Disease Reference
// http://oso.adam.com/


Adenoviruses
http://www.tulane.edu/~dmsander/WWW/...noviruses.html


AllRefer Health - Autoimmune Disorders
http://health.allrefer.com/health/au...ders-info.html


AllRefer Health - Celiac Disease - Sprue Support Groups
http://health.allrefer.com/health/ce...e-support.html


Alt.Support.Thyroid Newsgroup Website
http://www.altsupportthyroid.org/


American Academy of Dermatology
http://www.aad.org/

American Academy of Dermatology
http://www.skincarephysicians.com/eczemanet/whatIs.html

American Association of Immunologists
http://www.aai.org/

American Association of Immunologists Journal
http://www.jimmunol.org/


American Peptide Society
http://www.ampepsoc.org/


American Pharmaceutical Online References
http://www.medicalresourcesusa.com/pharmrefguide.htm



American Thyroid Association
http://www.thyroid.org/


Antigen Receptor Diversity



http://users.rcn.com/jkimball.ma.ult...Diversity.html


Applied Biosystems
http://www.appliedbiosystems.com/


Archives of
http://maelstrom.stjohns.edu/archives/celiac.html


Aspiration Biopsy of the Thyroid
http://www.thyroidfoundation.org/aspiration.htm


Asthma and Allergy Information and Research (AAIR) Home Page
http://www.users.globalnet.co.uk/~aair/


Atkins Diet & Low Carbohydrate Weight-Loss Support - Low Carb Diet

Recipes
&
Resources
http://www.lowcarb.ca/


Atkins Nutritionals Home
http://atkinscenter.com/dev/


AuthenticFoods
http://www.authenticfoods.com/


Autoimmune Disorders
http://www.thedoctorsdoctor.com/dise..._disorders.htm


Autoimmunity AARDA American Autoimmune Related Diseases Association
http://www.aarda.org/


B Cells and T Cells

http://users.rcn.com/jkimball.ma.ult...nd_Tcells.html


BBC - Science & Nature - Horizon - The Atkins Diet
http://www.bbc.co.uk/science/horizon...instrans.shtml


Canadian Celiac Association
http://www.celiac.ca/englishcca.html


Candida, Fibromyalgia, IBS, Celiac, Colitis, yeast infections, thrush,
sinusitis, leaky gut syndrome,etc
http://www.candidafree.net/pages/1/index.htm


Candida
http://www.candidafree.net/pages/1/index.htm


Carrageenan, Food Resource [http--food.oregonstate.edu-], Oregon State
University, Corvallis, OR
http://food.oregonstate.edu/gums/carr.html


Case Study A 37-Year-Old Man With Type 1 Diabetes, Vomiting, and

Diarrhea
http://journal.diabetes.org/clinical...1999/pg188.htm


CDC Health Topic Foodborne Illnesses
http://www.cdc.gov/health/foodill.htm


CELIAC (Celiac-Coeliac Wheat-Gluten-Free List)
http://www.enabling.org/ia/celiac/


Celiac Disease - DrGreene.com - caring for the next generation
http://www.drgreene.com/21_1522.html


Celiac Disease -- eCureMe.com
http://www.ecureme.com/emyhealth/Ped...ac_Disease.asp


Celiac disease and hypoparathyroidism cross-reaction of endomysial
antibodies with parathyroid tissue.



http://www.pubmedcentral.nih.gov/art...ype=abstrac t


Celiac Disease Foundation
http://www.celiac.org/


Celiac Disease NDDIC
http://digestive.niddk.nih.gov/ddise...liac/index.htm


Celiac Disease
http://digestive.niddk.nih.gov/ddise...liac/index.htm


Celiac Resources for Physicians
http://www.uams.edu/celiac/


Celiac Sprue Research Foundation
http://www.celiacsprue.org/


Celiac.com (Diagnosis & Treatment of Celiac Disease A Gluten-Free

Diet)



http://www.celiac.com/cgi-bin/webc.c...37103580146.6d


CELLS alive!
http://www.cellsalive.com/index.htm


Center For Celiac Research
http://www.celiaccenter.org/


Center for Science in the Public Interest
http://cspinet.org/


ChemQuik® - Free MSDS MSDS Service Mobile MSDS Chemical Inventory

AOS
http://www.chemquik.com/site/cq/welcome.asp


Chronic inflammatory cells



http://medweb.bham.ac.uk/http/depts/...F/infcell.html


Clan Thompson's Celiac Site
http://www.clanthompson.com/index.php3


Clinical Immunology Society
http://www.clinimmsoc.org/


Clonal Selection



http://users.rcn.com/jkimball.ma.ult...Selection.html


coeliac disease-gluten free info & message board (mainly UK)
http://coeliac.info/


Delphi Celiac Disease On-Line Support Group



http://forums.delphiforums.com/n/mai...li ac%2Fstart


Detecting Celiac Disease in Your Patients - March 1, 1998 - American

Academy
of Family Physicians
http://www.aafp.org/afp/980301ap/pruessn.html


Diabetes Care The High Prevalence of Autoantibodies to Tissue
Transglutaminase in First-Degree Relatives

http://www.findarticles.com/cf_dls/m.../article.jhtml


Dietary Soluble Fiber Resource
http://www.gy.com/index.htm


Digestion and Balance
http://www.medhelp.org/forums/gastro...es/35622a.html


Electronic Code of Federal Regulations
http://ecfr.gpoaccess.gov/


EnteroLab
http://www.enterolab.com/


Entrez-PubMed
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi


eosinophils
http://www.nursing.ucla.edu/userpage...c/eosinoph.htm


FDA-CFSAN Food Labeling Overview
http://www.cfsan.fda.gov/label.html


FDA-CFSAN Information about Food Allergies
http://vm.cfsan.fda.gov/~dms/wh-alrgy.html


Food and Drug Administration Home Page
http://www.fda.gov/


Food Safety and Inspection Service Home Page
http://www.fsis.usda.gov/


foodallergynetwork.com
http://foodallergynetwork.com/


FoodNet (CDC)
http://www.cdc.gov/foodnet/


Gastroenterology



http://www2.gastrojournal.org/script...r=home&id=gast


Gluten Free Brewing Project
http://www.fortunecity.com/boozers/b...eer/gfbeer.htm


Gluten Free Medications
http://www.glutenfreedrugs.com/


Gluten Intolerance Group of North America
http://www.gluten.net/


Gluten-Free Trading Company Home Page
http://www.gluten-free.tc/


Glycogen Metabolism
http://www.indstate.edu/thcme/mwking/glycogen.html


GMA, Food Allergy Alliance Develop Easy to Understand Labeling

Guidelines
GMA News Release 5-31-01
http://www.gmabrands.com/news/docs/N...cfm?DocID=767&


Google Search r-s medical
http://www.google.com/search?hl=en&i...&q=r-s+medical


Grain Inspection
http://www.usda.gov/gipsa/


GrainPuritySampling
http://www.usda.gov/gipsa/biotech/sample2.htm


GSDL Instestinal Permeability Assessment Application Guide
http://www.gsdl.com/assessments/ip/appguide/


Guar, Food Resource [http--food.oregonstate.edu-], Oregon State

University,
Corvallis, OR
http://food.oregonstate.edu/gums/guar.html


Gum Arabic, Food Resource [http--food.oregonstate.edu-], Oregon State
University, Corvallis, OR
http://food.oregonstate.edu/gums/arabic.html


HealthScout
http://www.healthscout.com/


Hospital Practice Recognizing Thyrotoxicosis
http://www.hosppract.com/issues/1999/05/dmmmazz.htm


How Antibodies are Produced
http://www.cellsalive.com/antibody.htm


http--www.cvm.okstate.edu-instruction-kocan-vpar5333-5333iid.htm
http://www.cvm.okstate.edu/instructi...33/5333iid.htm


http--www.inel.gov-x-web-other-framed.shtmlhttp--www.sisweb.com
http://www.inel.gov/x-web/other/fram...www.sisweb.com


http--www.nal.usda.gov-fnic-foodcomp-search-
http://www.nal.usda.gov/fnic/foodcomp/search/


http--www.whatnowheat.com-
http://www.whatnowheat.com/


Hypothyroidism and the TSH Reference Range - Alt.Support.Thyroid

Newsgroup
Website
http://www.altsupportthyroid.org/tsh/tshmedrefs1.php


IBM Life Sciences Web Lecture Series



http://www.ibmweblectureservices.iho...rigin=103ALE3S


IMMUNE DEFICIENCY FOUNDATION
http://www.primaryimmune.org/


Immune Recognition of the Mycobacterial Cell Wall
http://www.eurekah.com/abstract.php?...id=69&catid=73


Immune Tolerance Network - Industry Partnerships
http://www.immunetolerance.org/industry/


Immune Tolerance Network
http://www.immunetolerance.org/


Immune Web -- Support and Information Network
http://www.immuneweb.org/


Immunology of Diabetes Society Home Page
http://www.idsoc.org/


IMMUNOSCIENCES LAB.
http://www.immuno-sci-lab.com/2003_cat_page64.htm


Inflammation Long-Term Effects, from Arthritis.com
http://www.arthritis.com/1_5.asp


Inflammation Research Association
http://www.inflammationresearch.org/


Inflammation The Battle Within
http://arthritis.about.com/cs/arthge...flammation.htm


Inflammation, Heart Disease and Stroke The Role of C-Reactive Protein
http://www.americanheart.org/present...dentifier=4648


INFOMED ONLINE
http://www.infomed.org/



International Society for Mountain Medicine
http://www.ismmed.org/



Is Subclinical Gluten Intolerance-Celiac Disease Sabotaging Your

Health -
Thyroid Disease Information
http://www.thyroid-info.com/articles/glutenceliac.htm


Kaili's Kitchen
http://www.wheatlessinseattle.com/


Kimball's Biology Pages
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/


Lab Tests Online Welcome!
http://www.labtestsonline.org/


LAMISIL - Nail fungus treatment, tips for healthy nails
http://www.lamisil.com/index.jsp?checked=y


Legacy Laboratory Services - Legacy Health System - Portland, OR

http://www.legacyhealth.org/healthca...php?testid=387


Lipids Online - Educational Resources in Atherosclerosis and Coronary

Heart
Disease
http://www.lipidsonline.org/


Low Carb Research, Atkins Diet Research, Low Carb Diet Research
http://www.lowcarbresearch.org/lcr/results.asp


LOW CARBOHYDRATE RECIPES
http://www.carb-lite.au.com/fdbreakfast.html


Lymphoma Patients Information Resources
http://www.lymphoma.org.uk/support/i...on/Default.htm


Lymphoma Research Foundation Learning About Lymphoma
http://www.lymphoma.org/site/PageSer...ename=learning


Lymphoma Research Foundation
http://www.lymphoma.org/site/PageSer...gename=Seattle


Macular Pucker
http://www.vrmny.com/ERM.htm


Making Your Voice Heard at FDA How to Comment on Proposed Regulations

and
Submit Petitions
http://www.fda.gov/opacom/backgrounders/voice.html


MayoClinic.com - Medical and health information for a healthier life

from
Mayo Clinic
http://www.mayoclinic.com/invoke.cfm?id=DS00319


MDDI
http://www.devicelink.com/mddi/


MedicineNetInformation on Celiac disease
http://www.medicinenet.com/Celiac_Disease/article.htm


MedlinePlus Celiac Disease
http://www.nlm.nih.gov/medlineplus/celiacdisease.html


MEDLINEplus Health Information from the National Library of Medicine
http://www.nlm.nih.gov/medlineplus/medlineplus.html


MedlinePlus Medical Encyclopedia Autoimmune disorders
http://www.nlm.nih.gov/medlineplus/e...cle/000816.htm


Metabolic Pathways of Biochemistry
http://www.gwu.edu/~mpb/


Molecular Immunology
http://www.mi.interhealth.info/


Monterey Bay Aquarium Seafood Watch Program - Regional Seafood Watch

Cards
http://www.mbayaq.org/cr/cr_seafoodw...w_regional.asp


Muscle Biopsy
http://www.neuro.wustl.edu/neuromusc...ab/mbiopsy.htm


National Institute of Allergy and Infectious Diseases Home Page

(NIAID),
National Institutes of Health
http://www.niaid.nih.gov/default.htm


National Institute of Neurological Disorders and Stroke (NINDS)
http://www.ninds.nih.gov/


National Institute of Standards and Technology
http://nist.gov/


National Pork Producers Council
http://www.nppc.org/


Neuromuscular Muscle Autoantibodies
http://www.neuro.wustl.edu/neuromusc...mantibody.html


NIAID Links to Other Sites
http://www.niaid.nih.gov/information/externallinks.htm


Nikon MicroscopyU Confocal Image Gallery - Peyer's Patches
http://www.microscopyu.com/galleries...rspatches.html


NLM's Databases and Electronic Information Sources
http://www.nlm.nih.gov/databases/databases.html


No WorriesT Gluten-Free Bread Mix
http://www.noworriesbread.com/


OMIM - CELIAC DISEASE; CD
http://www.ncbi.nlm.nih.gov/entrez/d....cgi?id=212750


Pathology Teaching Menu
http://medweb.bham.ac.uk/http/depts/.../teachdir.html


Peptide bond - Wikipedia
http://en.wikipedia.org/wiki/Peptide_bond


Periodic table (WebElements)
http://www.webelements.com/


Planet Celiac--the gluten free place to be if you have celiac sprue --
recipes, books and more.
http://www.planetceliac.com/


PorkBoard
http://www.porkboard.org/Home/default.asp


PROWL - Amino Acid Properties
http://prowl.rockefeller.edu/aainfo/contents.htm


PsoriasisNet
http://www.skincarephysicians.com/ps...snet/index.htm


Science of dieting Slim pickings



http://www.nature.com/cgi-taf/DynaPa...28252a_fs.html


Seattle Celiac Support Group
http://www.seattleceliacs.com/


Seborrheic Dermatitis
http://www.aad.org/pamphlets/seborrhe.html


Skindex
http://www.skindex.com/index.html


Society for Mucosal Immunology
http://www.socmucimm.org/


Special Communication - March 8, 1995. Treatment Guidelines for
Hyperthyroidism and Hypothyroid



http://www.ama-assn.org/sci-pubs/jou..._10/sc4291.htm



Special Communication - March 8, 1995. Treatment Guidelines for
Hyperthyroidism and Hypothyroidism. (c) AMA 1996



http://www.ama-assn.org/sci-pubs/jou..._10/sc4291.htm


Specialty Laboratories - clinical reference laboratory contract

research
organization
http://www.specialtylabs.com/


StopAllergy.com Ask an Allergist
http://allergist.stopallergy.com/For...lth/Allergist/


Support Groups
http://www.whatnowheat.com/Support%20Groups.htm


Swedish Medical Center Home
http://www.swedish.org/home.asp?Home


The American Gastroenterological Association - Clinical Resources

(Patient
Brochures)
http://www.gastro.org/clinicalRes/brochures/ibd.html


The American Gastroenterological Association
http://www.gastro.org/


The Antibody Resource Page educational
http://www.antibodyresource.com/educational.html


The Gluten Free Kitchen
http://gfkitchen.server101.com/


The gluten free message board
http://members2.boardhost.com/gluten...html?999235741


The Great Plains Laboratory, your center of testing and analysis for

Autism,
Pervasive Developmental Disorder (PDD)
http://www.greatplainslaboratory.com/immune.html


The Merck Manual
http://www.merck.com/pubs/


The National Fibromyalgia Association
http://www.fmaware.org/


Thinner - guide to lowcarb weight loss
http://www.thinner.com/


ThirdAge - Health Newsletter - Overlooked, Under-Diagnosed Thyroid

Disease
Poses a Challenge

http://www.thirdage.com/news/article...040326-01.html


Thyroid Disease Manager, your source on thyroid disease,

hyperthyroidism,
hypothyroidism, thyroiditis,thyroid cancer
http://www.thyroidmanager.org/


Thyroid Disease Symptoms - Hypothyroidism Symptoms
http://www.armourthyroid.com/hypothy.../symptoms.html


TNFA promoter polymorphism and susceptibility to brucellosis - Clin

Exp
Immunol, Vol 121, Issue 3, pp. 480-483 (Full Text)



http://www.blackwell-synergy.com/lin....01331.x/full/


Two distinct hemolysins in Trichomonas tenax ATCC 30207 - Oral

Microbiol
Immunol, Vol 15, Issue 6, pp. 355-359 (Abstract)



http://www.blackwell-synergy.com/lin...d=bHR8zMK2xU2f

USDA NutrientDatabase
http://www.nal.usda.gov/fnic/foodcomp/search/


Van's Wheat Free Waffles.
http://www.vansintl.com/wheatfree.php


VCUendomysiumResident Cases
http://www.pathology.vcu.edu/WirSelfInst/muscle.html


virus-adeno
http://www.stanford.edu/group/virus/adeno/adeno.html


Voluntary Recall of Taco Bell Taco Shells containing StarLink Corn
http://www.cast-science.org/cast-sci...y/20000925.htm


WAFDO
http://www.wafdo.org/


WebRing hub
http://j.webring.com/hub?ring=celiac


Welcome to Medscape
http://www.medscape.com/px/urlinfo


Welcome to MedWeb
http://medweb.bham.ac.uk/


Welcome to the Gluten Intolerance Group of North America
http://www.gluten.net/


Welcome to the Incredible Edible Egg Website
http://www.aeb.org/


www.patientcenters.com -- Non-Hodgkin's Lymphoma Center -- What are

the
NHLs
http://www.patientcenters.com/lymphoma/news/nhl2.html


York Nutritional Laboratories, Inc... Better health begins at home
http://www.yorkallergyusa.com/


[Report] Treatment Algorithms 2000(Table of Contents)
http://www.the-infoshop.com/study/dc...rithm_toc.html




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  #10  
Old April 2nd, 2004, 11:52 AM
Sseaott
external usenet poster
 
Posts: n/a
Default What it all does to us.......

excuse me, IBS!


"Sseaott" SseaottATcomcastDOTnet wrote in message
...
I'm a kid?

Nice to know you know who I am when you don't know me lol.

This is a newsgroup about carbs, NOT IMBS!

ONCE AGAIN

P
L
O
N
K
!


"TavliGal" wrote in message
news:7labc.10560$oR5.813@pd7tw3no...
Laurence wrote:
What? Wrong place to post this? How many here have IBS? Or
similar?

Don't worry about him Laurence, he's just a kid and a twit to boot. He
"plonks" everyone he doesn't agree with or likes.
I've heard of a few people who have IBS around here.

Monica
--
Started 01/20/04
362/322.4/250
__________________________________________________ ______
"Watch what people are cynical about, and one can often discover
what they lack. - Harry Emerson Fosdick




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