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Body-mass index and mortality in a prospective cohort of U.S. adults.
N Engl J Med. 1999 Oct 7;341(15):1097-105.
Body-mass index and mortality in a prospective cohort of U.S. adults. Calle EE, Thun MJ, Petrelli JM, Rodriguez C, Heath CW Jr. Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA 30329, USA. BACKGROUND: Body-mass index (the weight in kilograms divided by the square of the height in meters) is known to be associated with overall mortality. We investigated the effects of age, race, sex, smoking status, and history of disease on the relation between body-mass index and mortality. METHODS: In a prospective study of more than 1 million adults in the United States (457,785 men and 588,369 women), 201,622 deaths occurred during 14 years of follow-up. We examined the relation between body-mass index and the risk of death from all causes in four subgroups categorized according to smoking status and history of disease. In healthy people who had never smoked, we further examined whether the relation varied according to race, cause of death, or age. The relative risk was used to assess the relation between mortality and body-mass index. RESULTS: The association between body-mass index and the risk of death was substantially modified by smoking status and the presence of disease. In healthy people who had never smoked, the nadir of the curve for body-mass index and mortality was found at a body-mass index of 23.5 to 24.9 in men and 22.0 to 23.4 in women. Among subjects with the highest body-mass indexes, white men and women had a relative risk of death of 2.58 and 2.00, respectively, as compared with those with a body-mass index of 23.5 to 24.9. Black men and women with the highest body-mass indexes had much lower risks of death (1.35 and 1.21), which did not differ significantly from 1.00. A high body-mass index was most predictive of death from cardiovascular disease, especially in men (relative risk, 2.90; 95 percent confidence interval, 2.37 to 3.56). Heavier men and women in all age groups had an increased risk of death. CONCLUSIONS: The risk of death from all causes, cardiovascular disease, cancer, or other diseases increases throughout the range of moderate and severe overweight for both men and women in all age groups. The risk associated with a high body-mass index is greater for whites than for blacks. **** -- Steve º¤º°`°º¤ø,¸¸,ø¤º°`°º¤º Steve Chaney Remove "Vegetus." to get my real email address See the soc.singles HALL OF STUPID: http://member.newsguy.com/~gunhed/hallofstupid "If only sheep could cook, we wouldn't need women at all! 8)" - Dizzy, Message-ID: "Outside of this group, I don't remember hearing anyone in RL say that fat people are worthless." - some anonymous coward admitting the truth, Message-ID: "I watched The Accused last night with Jodie Foster. Tough movie. I was wondering what people felt as to whether or not they feel she deserved what happened to her." - Brenda Lee Ehmka, Message-ID: "Jade, your whole existence is spent trying to find people you can justify vetting your rage toward thorugh all forms of harassment. Do you realize that?" - Sunny, on Jade's life in a nutshell |
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