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#21
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Healthy saturated fat?
Hi Ig: do you have any references to valid current research (randomized controlled studies) of saturated animal fat? I looked a lot in medline yesterday, and besides the study that I posted to start this thread, there was nothing. Dozens of references to saturated fat as bad without any substantiation. Some key words/phrases: ceramide, beta cell apoptosis High-Wire search for phrase "beta cell apoptosis"+saturated+fatty resulted in 57 finds - http://tinyurl.com/4tsud. Adding ceramide to the above search terms resulted in 34 finds - http://tinyurl.com/6oysd Palmitate is a type of saturated fatty acid. Monounsaturated Fatty Acids Prevent the Deleterious Effects of Palmitate and High Glucose on Human Pancreatic ß-Cell Turnover and Function http://diabetes.diabetesjournals.org.../full/52/3/726 "Glucotoxicity and lipotoxicity contribute to the impaired ß-cell function observed in type 2 diabetes. Here we examine the effect of saturated and monounsaturated fatty acids at different glucose concentrations on human ß-cell turnover and secretory function. Exposure of cultured human islets to saturated fatty acid and/or to an elevated glucose concentration for 4 days increased ß-cell DNA fragmentation and decreased ß-cell proliferation. In contrast, the monounsaturated palmitoleic acid or oleic acid did not affect DNA fragmentation and induced ß-cell proliferation. Moreover, each monounsaturated fatty acid prevented the deleterious effects of both palmitic acid and high glucose concentration. The cell-permeable ceramide analogue C2-ceramide mimicked both the palmitic acid-induced ß-cell apoptosis and decrease in proliferation. Furthermore, the ceramide synthetase inhibitor fumonisin B1 blocked the deleterious effects of palmitic acid on ß-cell turnover. In addition, palmitic acid decreased Bcl-2 expression and induced release of cytochrome c from the mitochondria into the cytosol, which was prevented by fumonisin B1 and by oleic acid. Finally, each monounsaturated fatty acid improved ß-cell secretory function that was reduced by palmitic acid and by high glucose. Thus, in human islets, the saturated palmitic acid and elevated glucose concentration induce ß-cell apoptosis, decrease ß-cell proliferation, and impair ß-cell function, which can be prevented by monounsaturated fatty acids. The deleterious effect of palmitic acid is mediated via formation of ceramide and activation of the apoptotic mitochondrial pathway, whereas Bcl-2 may contribute to the protective effect of monounsaturated fatty acids." Read the whole article and some others in the searches above. Also read some of the follow up articles that cite the articles. Free fatty acids (FFA) are also significant for type 2 diabetes and can result from dyfunctional metabolism of protein, carbohydrates, and fatty acids particularly when there is a positive energy balance such as occurs in eating to much and not getting enough exercise. Frank |
#22
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Healthy saturated fat?
jbuch wrote: I am sure that if you look, you will find plenty of uses of the saturated fats in basic body cellular structures. However, I have no good references.... just some vague recollections which could be mistaken... This is probably true. The nitty-gritty issue is really one of balance. It is like arachidonic acid (AA) derived from omega 6 series fatty acids. AA is important in some physiological actions, but it can give you a headache or other aches and pains if you have a bad omega 6 to omega 3 balance in your diet. Frank |
#23
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Healthy saturated fat?
Jefferson wrote:
jbuch wrote: I am sure that if you look, you will find plenty of uses of the saturated fats in basic body cellular structures. However, I have no good references.... just some vague recollections which could be mistaken... This is probably true. The nitty-gritty issue is really one of balance. It is like arachidonic acid (AA) derived from omega 6 series fatty acids. AA is important in some physiological actions, but it can give you a headache or other aches and pains if you have a bad omega 6 to omega 3 balance in your diet. Frank Yes, Balance. we really screw ourselves up with the attitude that: "If a little is good, a lot must be better." Rather than..."Now that I've got that, what else do I need to add to it?" These answers, unfortunately, won't work out to be identical for all, because we complex bio-machines are built with all kinds of modest programming errors. Carbohydrate handling problems for some, Fat handling problems for others, Cholesterol handling problems for still others, and even more problems in case you haven't gotten one of the above. Trial and ERROR still seems necessary. Jim Jim |
#24
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Healthy saturated fat?
Jefferson wrote:
jbuch wrote: I am sure that if you look, you will find plenty of uses of the saturated fats in basic body cellular structures. However, I have no good references.... just some vague recollections which could be mistaken... This is probably true. The nitty-gritty issue is really one of balance. It is like arachidonic acid (AA) derived from omega 6 series fatty acids. AA is important in some physiological actions, but it can give you a headache or other aches and pains if you have a bad omega 6 to omega 3 balance in your diet. Frank Yes, Balance. we really screw ourselves up with the attitude that: "If a little is good, a lot must be better." Rather than..."Now that I've got that, what else do I need to add to it?" These answers, unfortunately, won't work out to be identical for all, because we complex bio-machines are built with all kinds of modest programming errors. Carbohydrate handling problems for some, Fat handling problems for others, Cholesterol handling problems for still others, and even more problems in case you haven't gotten one of the above. Trial and ERROR still seems necessary. Jim Jim |
#25
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Healthy saturated fat?
Alan wrote:
Possibly one of those "many a true word spoken in jest" statements. I don't get palpitations over sat fat (just finished my bacon and egg breakfast - steak for dinner tonight) but I do trim and drain as much as possible. It's all a matter of balance; so lipids, BGs, excess weight, exercise are all part of the equation. I'm getting to be of the opinion that there is no 'right diet' suitable for 'everyone' with regard to macronutrients (iow fat+protein+carbohydrate). I've always had problems with wheat. After diebetes, with all starch. I'm getting to think that some are suited for a mainly sat fat/meat diet, others more towards fish/unsaturated fat, still others a vegetarian diet, still others a diet high in carbohydrate. For me, a diet high in fish/protein/ and vegetables with a low carb concentration seems to work best. but I'd be wary of recommending it to anyone else for the reasons stated above. Wouldn't it be easy if one size fits all. But it seems that for some of us, there isn't even a size. -- John38 : t2 since 11/03 |
#26
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Healthy saturated fat?
Alan wrote:
Possibly one of those "many a true word spoken in jest" statements. I don't get palpitations over sat fat (just finished my bacon and egg breakfast - steak for dinner tonight) but I do trim and drain as much as possible. It's all a matter of balance; so lipids, BGs, excess weight, exercise are all part of the equation. I'm getting to be of the opinion that there is no 'right diet' suitable for 'everyone' with regard to macronutrients (iow fat+protein+carbohydrate). I've always had problems with wheat. After diebetes, with all starch. I'm getting to think that some are suited for a mainly sat fat/meat diet, others more towards fish/unsaturated fat, still others a vegetarian diet, still others a diet high in carbohydrate. For me, a diet high in fish/protein/ and vegetables with a low carb concentration seems to work best. but I'd be wary of recommending it to anyone else for the reasons stated above. Wouldn't it be easy if one size fits all. But it seems that for some of us, there isn't even a size. -- John38 : t2 since 11/03 |
#27
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Healthy saturated fat?
John38 generously shared with us this little ditty:
Alan wrote: Possibly one of those "many a true word spoken in jest" statements. I don't get palpitations over sat fat (just finished my bacon and egg breakfast - steak for dinner tonight) but I do trim and drain as much as possible. It's all a matter of balance; so lipids, BGs, excess weight, exercise are all part of the equation. I'm getting to be of the opinion that there is no 'right diet' suitable for 'everyone' with regard to macronutrients (iow fat+protein+carbohydrate). I've always had problems with wheat. After diebetes, with all starch. I'm getting to think that some are suited for a mainly sat fat/meat diet, others more towards fish/unsaturated fat, still others a vegetarian diet, still others a diet high in carbohydrate. For me, a diet high in fish/protein/ and vegetables with a low carb concentration seems to work best. but I'd be wary of recommending it to anyone else for the reasons stated above. Wouldn't it be easy if one size fits all. But it seems that for some of us, there isn't even a size. Wize man. -- revek "Time is an illusion perpetrated by the manufacturers of space." |
#28
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Healthy saturated fat?
John38 generously shared with us this little ditty:
Alan wrote: Possibly one of those "many a true word spoken in jest" statements. I don't get palpitations over sat fat (just finished my bacon and egg breakfast - steak for dinner tonight) but I do trim and drain as much as possible. It's all a matter of balance; so lipids, BGs, excess weight, exercise are all part of the equation. I'm getting to be of the opinion that there is no 'right diet' suitable for 'everyone' with regard to macronutrients (iow fat+protein+carbohydrate). I've always had problems with wheat. After diebetes, with all starch. I'm getting to think that some are suited for a mainly sat fat/meat diet, others more towards fish/unsaturated fat, still others a vegetarian diet, still others a diet high in carbohydrate. For me, a diet high in fish/protein/ and vegetables with a low carb concentration seems to work best. but I'd be wary of recommending it to anyone else for the reasons stated above. Wouldn't it be easy if one size fits all. But it seems that for some of us, there isn't even a size. Wize man. -- revek "Time is an illusion perpetrated by the manufacturers of space." |
#29
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Healthy saturated fat?
"John38" wrote in message
... For me, a diet high in fish/protein/ and vegetables with a low carb concentration seems to work best. but I'd be wary of recommending it to anyone else for the reasons stated above. Wouldn't it be easy if one size fits all. But it seems that for some of us, there isn't even a size. Is your blood type O? My mother swears by this blood type diet she is on, "Eat Right For Your Type." It sounded kind of weird to me, but then I read a science magazine article about them trying to come up with genetic tests to predict which drugs will work for different people which seems like a similar kind of thing. |
#30
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Healthy saturated fat?
In article , None Given
writes "John38" wrote in message ... For me, a diet high in fish/protein/ and vegetables with a low carb concentration seems to work best. but I'd be wary of recommending it to anyone else for the reasons stated above. Wouldn't it be easy if one size fits all. But it seems that for some of us, there isn't even a size. Is your blood type O? My mother swears by this blood type diet she is on, "Eat Right For Your Type." It sounded kind of weird to me, but then I read a science magazine article about them trying to come up with genetic tests to predict which drugs will work for different people which seems like a similar kind of thing. you know, I have no idea what my blood type is. I would be interested in the science describing the dietblood type relationship. Any links? -- John38 : t2 since 11/03 : current Hb1Ac=5.5% : |
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