Healthy saturated fat?

But doesn't Jenny say (based on her readings, mind you) that SF is harmful
the beta cells of a diabetic person?

Ignoramus7404 wrote:
:: What a bummer!
::
:: ``The present study demonstrated that the addition of SF to the meal
:: resulted in lower postprandial glucose and insulin than when the meal
:: contained MUFA. Thus, SF may be useful in controlling postprandial
:: glucose.''
::
::
http://www.ncbi.nlm.nih.gov/entrez/q..._uids=10774766
::
:: Comparison of the effect of saturated and monounsaturated fat on
:: postprandial plasma glucose and insulin concentration in women with
:: gestational diabetes mellitus.
::
:: Ilic S, Jovanovic L, Pettitt DJ.
::
:: Sansum Medical Research Institute, Santa Barbara, California 93105,
:: USA.
::
:: The goal of this study was to determine whether the type of fat plays
:: a role in the glucose response to a meal, independent of the
:: carbohydrate content. Ten gestational diabetic women (gestational
:: weeks 29-34) who were well controlled on diet alone were randomized
:: as to the order in which they would eat a meal, after overnight fast,
:: containing saturated fat (SF) or monounsaturated fat (MUFA). Blood
:: was drawn at 0, 60, 120, and 180 min for plasma glucose, insulin,
:: lipid profile (triglycerides, total cholesterol, HDL-cholesterol,
:: LDL-cholesterol, VLDL-cholesterol) and free fatty acids. After 2
:: weeks, each patient received the other type of meal. The test meal
:: was composed of 20% of the total daily caloric needs based on ideal
:: body weight. The area under the curve showed a significantly lower
:: glucose concentration for SF meal (p = 0.001). Serum insulin
:: concentrations followed the glucose response with the peak at the
:: 60-min time point and a significantly lower concentration at the
:: 180-min time point in the SF than in the MUFA group. The present
:: study demonstrated that the addition of SF to the meal resulted in
:: lower postprandial glucose and insulin than when the meal contained
:: MUFA. Thus, SF may be useful in controlling postprandial glucose.

But doesn't Jenny say (based on her readings, mind you) that SF is harmful
the beta cells of a diabetic person?

Ignoramus7404 wrote:
:: What a bummer!
::
:: ``The present study demonstrated that the addition of SF to the meal
:: resulted in lower postprandial glucose and insulin than when the meal
:: contained MUFA. Thus, SF may be useful in controlling postprandial
:: glucose.''
::
::
http://www.ncbi.nlm.nih.gov/entrez/q..._uids=10774766
::
:: Comparison of the effect of saturated and monounsaturated fat on
:: postprandial plasma glucose and insulin concentration in women with
:: gestational diabetes mellitus.
::
:: Ilic S, Jovanovic L, Pettitt DJ.
::
:: Sansum Medical Research Institute, Santa Barbara, California 93105,
:: USA.
::
:: The goal of this study was to determine whether the type of fat plays
:: a role in the glucose response to a meal, independent of the
:: carbohydrate content. Ten gestational diabetic women (gestational
:: weeks 29-34) who were well controlled on diet alone were randomized
:: as to the order in which they would eat a meal, after overnight fast,
:: containing saturated fat (SF) or monounsaturated fat (MUFA). Blood
:: was drawn at 0, 60, 120, and 180 min for plasma glucose, insulin,
:: lipid profile (triglycerides, total cholesterol, HDL-cholesterol,
:: LDL-cholesterol, VLDL-cholesterol) and free fatty acids. After 2
:: weeks, each patient received the other type of meal. The test meal
:: was composed of 20% of the total daily caloric needs based on ideal
:: body weight. The area under the curve showed a significantly lower
:: glucose concentration for SF meal (p = 0.001). Serum insulin
:: concentrations followed the glucose response with the peak at the
:: 60-min time point and a significantly lower concentration at the
:: 180-min time point in the SF than in the MUFA group. The present
:: study demonstrated that the addition of SF to the meal resulted in
:: lower postprandial glucose and insulin than when the meal contained
:: MUFA. Thus, SF may be useful in controlling postprandial glucose.

On Tue, 3 Aug 2004 11:18:00 -0500, "revek" wrote:


As in: oh gee, lookitthis, too bad it will kill you with heart disease
while it manages your diabetes!

Possibly one of those "many a true word spoken in jest" statements. I
don't get palpitations over sat fat (just finished my bacon and egg
breakfast - steak for dinner tonight) but I do trim and drain as much as
possible. It's all a matter of balance; so lipids, BGs, excess weight,
exercise are all part of the equation.


Cheers, Alan, T2 d&e, Australia.
Remove weight and carbs to email.
--
Everything in Moderation - Except Laughter.

On Tue, 3 Aug 2004 11:18:00 -0500, "revek" wrote:


As in: oh gee, lookitthis, too bad it will kill you with heart disease
while it manages your diabetes!

Possibly one of those "many a true word spoken in jest" statements. I
don't get palpitations over sat fat (just finished my bacon and egg
breakfast - steak for dinner tonight) but I do trim and drain as much as
possible. It's all a matter of balance; so lipids, BGs, excess weight,
exercise are all part of the equation.


Cheers, Alan, T2 d&e, Australia.
Remove weight and carbs to email.
--
Everything in Moderation - Except Laughter.

On Tue, 3 Aug 2004 11:18:00 -0500, "revek" wrote:


As in: oh gee, lookitthis, too bad it will kill you with heart disease
while it manages your diabetes!

Possibly one of those "many a true word spoken in jest" statements. I
don't get palpitations over sat fat (just finished my bacon and egg
breakfast - steak for dinner tonight) but I do trim and drain as much as
possible. It's all a matter of balance; so lipids, BGs, excess weight,
exercise are all part of the equation.


Cheers, Alan, T2 d&e, Australia.
Remove weight and carbs to email.
--
Everything in Moderation - Except Laughter.

Alan generously shared with us this little ditty:
On Tue, 3 Aug 2004 11:18:00 -0500, "revek"
wrote:


As in: oh gee, lookitthis, too bad it will kill you with heart
disease while it manages your diabetes!

Possibly one of those "many a true word spoken in jest" statements. I
don't get palpitations over sat fat (just finished my bacon and egg
breakfast - steak for dinner tonight) but I do trim and drain as much
as possible. It's all a matter of balance; so lipids, BGs, excess
weight, exercise are all part of the equation.


Cheers, Alan, T2 d&e, Australia.
Remove weight and carbs to email.

Whatever works for you is what you need to go with. However sat fat is
not the evil so many have made it out to be.

--
revek
".Sig, .sig a .sog, .sig out loud, .sig out .strog ." -- Karen
Carpenter with a head cold.

Alan generously shared with us this little ditty:
On Tue, 3 Aug 2004 11:18:00 -0500, "revek"
wrote:


As in: oh gee, lookitthis, too bad it will kill you with heart
disease while it manages your diabetes!

Possibly one of those "many a true word spoken in jest" statements. I
don't get palpitations over sat fat (just finished my bacon and egg
breakfast - steak for dinner tonight) but I do trim and drain as much
as possible. It's all a matter of balance; so lipids, BGs, excess
weight, exercise are all part of the equation.


Cheers, Alan, T2 d&e, Australia.
Remove weight and carbs to email.

Whatever works for you is what you need to go with. However sat fat is
not the evil so many have made it out to be.

--
revek
".Sig, .sig a .sog, .sig out loud, .sig out .strog ." -- Karen
Carpenter with a head cold.

Bob in CT wrote:


I suspect, based on my current readings, that saturated fat is
maligned unfairly. That was the basis for the humorous attitude, so
see saturated fat perform pretty well.

I was surprised that saturated fat worked BETTER THAN OTHER
FATS. That, to be, is counterintuitive. Why does it work better? I do
not know.

i


Personally, I'm surprised that saturated fat is bad, simply from a
chemical perspective. Saturated fat means that all possible locations
on the fat are filled. To me, this should yield a relatively inert
substance. However, the body isn't always logical.


I am sure that if you look, you will find plenty of uses of the
saturated fats in basic body cellular structures.

However, I have no good references.... just some vague recollections
which could be mistaken...

Jim

Bob in CT wrote:


I suspect, based on my current readings, that saturated fat is
maligned unfairly. That was the basis for the humorous attitude, so
see saturated fat perform pretty well.

I was surprised that saturated fat worked BETTER THAN OTHER
FATS. That, to be, is counterintuitive. Why does it work better? I do
not know.

i


Personally, I'm surprised that saturated fat is bad, simply from a
chemical perspective. Saturated fat means that all possible locations
on the fat are filled. To me, this should yield a relatively inert
substance. However, the body isn't always logical.


I am sure that if you look, you will find plenty of uses of the
saturated fats in basic body cellular structures.

However, I have no good references.... just some vague recollections
which could be mistaken...

Jim

Hi Ig:

do you have any references to valid current research (randomized
controlled studies) of saturated animal fat? I looked a lot in medline
yesterday, and besides the study that I posted to start this thread,
there was nothing. Dozens of references to saturated fat as bad
without any substantiation.


Some key words/phrases: ceramide, beta cell apoptosis
High-Wire search for phrase "beta cell apoptosis"+saturated+fatty
resulted in 57 finds - http://tinyurl.com/4tsud.

Adding ceramide to the above search terms resulted in 34 finds -
http://tinyurl.com/6oysd

Palmitate is a type of saturated fatty acid.

Monounsaturated Fatty Acids Prevent the Deleterious Effects of Palmitate
and High Glucose on Human Pancreatic ß-Cell Turnover and Function
http://diabetes.diabetesjournals.org.../full/52/3/726
"Glucotoxicity and lipotoxicity contribute to the impaired ß-cell
function observed in type 2 diabetes. Here we examine the effect of
saturated and monounsaturated fatty acids at different glucose
concentrations on human ß-cell turnover and secretory function. Exposure
of cultured human islets to saturated fatty acid and/or to an elevated
glucose concentration for 4 days increased ß-cell DNA fragmentation and
decreased ß-cell proliferation. In contrast, the monounsaturated
palmitoleic acid or oleic acid did not affect DNA fragmentation and
induced ß-cell proliferation. Moreover, each monounsaturated fatty acid
prevented the deleterious effects of both palmitic acid and high glucose
concentration. The cell-permeable ceramide analogue C2-ceramide mimicked
both the palmitic acid-induced ß-cell apoptosis and decrease in
proliferation. Furthermore, the ceramide synthetase inhibitor fumonisin
B1 blocked the deleterious effects of palmitic acid on ß-cell turnover.
In addition, palmitic acid decreased Bcl-2 expression and induced
release of cytochrome c from the mitochondria into the cytosol, which
was prevented by fumonisin B1 and by oleic acid. Finally, each
monounsaturated fatty acid improved ß-cell secretory function that was
reduced by palmitic acid and by high glucose. Thus, in human islets, the
saturated palmitic acid and elevated glucose concentration induce ß-cell
apoptosis, decrease ß-cell proliferation, and impair ß-cell function,
which can be prevented by monounsaturated fatty acids. The deleterious
effect of palmitic acid is mediated via formation of ceramide and
activation of the apoptotic mitochondrial pathway, whereas Bcl-2 may
contribute to the protective effect of monounsaturated fatty acids."

Read the whole article and some others in the searches above. Also read
some of the follow up articles that cite the articles. Free fatty acids
(FFA) are also significant for type 2 diabetes and can result from
dyfunctional metabolism of protein, carbohydrates, and fatty acids
particularly when there is a positive energy balance such as occurs in
eating to much and not getting enough exercise.

Frank