lowering of metabolism after weight loss

Polar Light wrote:


When you say 'obesity is said to be related to genetics', what does it mean?
Is it the tendency to overeat? the bigger apetite? the taste for high
calorie food?
or do obese people really have a slower metabolism? or better absorption?

It can be lots of things.

http://www.eurekalert.org/pub_releas...-jtt011905.php
http://fatnews.com/index.php/weblog/...d-by-heredity/
http://fatnews.com/index.php/weblog/comments/1497/
http://fatnews.com/index.php/weblog/...oss_in_blacks/
http://query.nytimes.com/gst/abstrac...0894DB4044 82
http://www.eurekalert.org/pub_releas...-ona020303.php
http://www.washingtonmonthly.com/fea....mencimer.html
http://www.ncbi.nlm.nih.gov/entrez/q..._uids=14660491
http://www.ima.org.il/imaj/ar02sep-13.pdf
http://www.wvdhhr.org/bph/oehp/obesity/section1.htm

* http://www.the-scientist.com/2002/04/29/22/1

Genes Do Play a Role in Obesity

For some people, overeating is not the only culprit By Myrna E. Watanabe
Sedentary people who enjoy high-caloric diets—adults and children
alike—are getting dangerously fat.1 Along with the increased weight
comes complications. Take obesity, for example. It is a risk factor for
Type 2 diabetes. Once considered a strictly adult disease, Type 2
diabetes is now diagnosed in both preadolescents and adolescents.2 Some
researchers believe that the interaction between obesity-related genes
and society's increasingly sedentary lifestyle and fat-filled diet is to
blame. The questions of when and how the environmental triggers set off
the genes have, as of yet, no answers. The first hint that obesity has a
genetic rather than a totally behavioral basis came in 1994 when
Rockefeller University researchers identified the obese gene and cloned
the murine version of it.3 The mice were obese, suffered from Type 2
diabetes, and lacked the protein leptin which appears to act primarily
on the hypothalamus, where it influences appetite and energy use. The
discovery opened the genetic floodgates. "It? was the paradigm shift
that turned obesity? into a tractable problem," remarks clinical
endocrinologist Stephen O'Rahilly, University of Cambridge, who studies
the genetics of childhood obesity. O'Rahilly's research had focused on
severe insulin resistance in children; after the discovery, he shifted
to investigating leptin deficiency in extremely obese youngsters and
their families. "Among the first kids we looked at, we did find a pair
of first cousins who were leptin? deficient," says O'Rahilly. In total,
they found three families with this deficit; the children had extremely
large appetites. "It was the first demonstration that a human being
could become severely obese on the basis of a simple genetic defect," he
states.4 O'Rahilly points out that these children are not comparable to
the average, overeating child in the United States or United Kingdom;
the leptin-deficient children would become obese as long as food was
available. But even more remarkable than the gene's discovery and its




It's a combination of both. Weight gain/loss is physiological but
psychological factors affect what you eat. If you're dying for a BigMac it's
more likely to be because of advertising you've seen than for genetical
reasons.

It could be because you have fewer dopamine receptors and the fat and
sugar have lit up your attention system and kick in all the mechanisms
to get you to eat.

http://www.eurekalert.org/pub_releas...-bra110404.php


It may be their
mind that makes them eat like that but their bodies accept it, who is to
blame, body or mind?

You act like they are separate. They aren't.

"wendy" wrote in message
...
GaryG wrote:
Well...it's not rocket science either. Losing weight simply requires
consuming a few less calories per day than one burns.

And running a 4 minute mile simply require running a mile under 4 minutes.

Not everyone is able to run a 4-minute mile - it's not physically possible.

But, it is physically possible for anyone to consume a few less calories
than they burn each day. It can be challenging, because of they availability
of food, and the way it is consumed recreationally and socially.

Is it easy to lose weight? No.

Is it possible? Yes.



As with many other things in life, anything that requires patience and
persistence will tend to have a low rate of success. It's just a lot
easier
for most people to reach for the bag of snacks and the remote control,
rather than get up off the couch and go for a walk. But, that's more an
issue of personal priorities than metabolism.

Why is it easier? You don't forget to breath. You don't over drink
water. Why do you want to eat the snacks and use the remote control? It
could be different, but it's not. The influences are so built-in we
don't even recognize they are at play.

I didn't say it was easy...but, it's not as impossible as you make it sound.
One does have to become "aware", and make more intelligent choices with
respect to food choices and portions, and exercise. But, plenty of people
manage to do this.

GG

GaryG wrote:
The rate of obesity is skyrocketing...are you saying that's due to genetics?
Why were so few people obese 50 years ago?

We are genetically programmed to eat like crazy because that's what is
required to survive. Eating is an organisms number one job, even before
reproduction, and we have lot of overlapping mechanisms to keep us
eating and few to stop eating.

The reason you want to eat is genetic. In the past food was not highly
available so this made a lot of sense. In a scarce food environment you
need a strong drive to eat. Otherwise would you eat? Not really. No more
than you take out the garbage regularly. What stops you from eating?
Very little and for good reason. Can you imagine having a fresh kill and
saying no thanks, i'll wait a week for the next one? Can you imagine
have a big haunch of deer and saying i don't feel like finishing it when
you know your next meal could be in another 3 days? It's not really
rational to expect our biology to work in a world of plenty when it was
"designed" for a world of scarcity.

We also have no instinct to exercise. It's the reverse because it not
exercising wasn't an option. Hunter-gathers walked something like 6-12
miles a day. What we wanted to do was conserve energy. So when we don't
have to do anything we don't.

Now add in that 100 calories extra a day is 10 extra pounds a year. Over
10 years that's 100 pounds. So it takes very little extra for us to
become obese.

50 years ago we simply didn't have the availability of high caloric
density food and we didn't have a drive everywhere do nothing culture.

McDonalds had a goal of making a store available to everyone in the
world in under 5 minutes. That's very different than a few generations
ago. I remember my grandma's stories about the depression.

Fast food has for the first time made highly caloric fatty and sugary
food availble to the masses at and affordable price. These ingredients
activate our reward systems just like heroine does. Not to the same
extent, but it's really the first food that has had the same effect. Why
does the body make this food addictive? So you'll eat it! Fat is
calories. Those calories are what allowed us to develop bigger brains.
Sugar is fruit which is vitamins. That's how the body gets you to do
what it wants. Just like it uses leptin and ghrelin and a zillion other
chemicals to control your hunger.

Now can you exercise? Yes. Can you stop from eating? Yes. Can you hold
your arms up for half hour? Yes. Can you hold your breath until you pass
out? Yes. Can you control your heart rate? Yes. But realize how much we
are going against the tide here. And depending on your genetics it can
be a lot harder than for others.

GaryG wrote:
"wendy" wrote in message
...

GaryG wrote:

Well...it's not rocket science either. Losing weight simply requires
consuming a few less calories per day than one burns.

And running a 4 minute mile simply require running a mile under 4 minutes.


Not everyone is able to run a 4-minute mile - it's not physically possible.

Rubish. It's just mind over matter. Just eat less exercise more. Wait,
that's for weight.

But, it is physically possible for anyone to consume a few less calories
than they burn each day.

And you know this how? As we are just learning about most of these
mechanisms and we are only a generation or two into the world of plenty
without exercise- there's no way for you to know. All evidence is going
the other way. Many yogis can control their breathing so they can stay
in a coffin for days. It's possible. Can the other 99.999956% of
humanity? Unlikely.

"wendy" wrote in message
...
GaryG wrote:
"wendy" wrote in message
...

GaryG wrote:

Well...it's not rocket science either. Losing weight simply requires
consuming a few less calories per day than one burns.

And running a 4 minute mile simply require running a mile under 4
minutes.


Not everyone is able to run a 4-minute mile - it's not physically
possible.

Rubish. It's just mind over matter. Just eat less exercise more. Wait,
that's for weight.

But, it is physically possible for anyone to consume a few less calories
than they burn each day.

And you know this how? As we are just learning about most of these
mechanisms and we are only a generation or two into the world of plenty
without exercise- there's no way for you to know. All evidence is going
the other way. Many yogis can control their breathing so they can stay
in a coffin for days. It's possible. Can the other 99.999956% of
humanity? Unlikely.

So, we should all just give up then? Look for help through drugs and
surgery?

A wise person once said, "If you think you can, or you think you can't...you
are correct."

GG

"wendy" wrote in message
...
GaryG wrote:
The rate of obesity is skyrocketing...are you saying that's due to
genetics?
Why were so few people obese 50 years ago?

We are genetically programmed to eat like crazy because that's what is
required to survive. Eating is an organisms number one job, even before
reproduction, and we have lot of overlapping mechanisms to keep us
eating and few to stop eating.

We're also genetically programmed to mate like crazy, and to commit homicide
when our territory is threatened. But, most of us manage to control those
instinctual drives.

GG


The reason you want to eat is genetic. In the past food was not highly
available so this made a lot of sense. In a scarce food environment you
need a strong drive to eat. Otherwise would you eat? Not really. No more
than you take out the garbage regularly. What stops you from eating?
Very little and for good reason. Can you imagine having a fresh kill and
saying no thanks, i'll wait a week for the next one? Can you imagine
have a big haunch of deer and saying i don't feel like finishing it when
you know your next meal could be in another 3 days? It's not really
rational to expect our biology to work in a world of plenty when it was
"designed" for a world of scarcity.

We also have no instinct to exercise. It's the reverse because it not
exercising wasn't an option. Hunter-gathers walked something like 6-12
miles a day. What we wanted to do was conserve energy. So when we don't
have to do anything we don't.

Now add in that 100 calories extra a day is 10 extra pounds a year. Over
10 years that's 100 pounds. So it takes very little extra for us to
become obese.

50 years ago we simply didn't have the availability of high caloric
density food and we didn't have a drive everywhere do nothing culture.

McDonalds had a goal of making a store available to everyone in the
world in under 5 minutes. That's very different than a few generations
ago. I remember my grandma's stories about the depression.

Fast food has for the first time made highly caloric fatty and sugary
food availble to the masses at and affordable price. These ingredients
activate our reward systems just like heroine does. Not to the same
extent, but it's really the first food that has had the same effect. Why
does the body make this food addictive? So you'll eat it! Fat is
calories. Those calories are what allowed us to develop bigger brains.
Sugar is fruit which is vitamins. That's how the body gets you to do
what it wants. Just like it uses leptin and ghrelin and a zillion other
chemicals to control your hunger.

Now can you exercise? Yes. Can you stop from eating? Yes. Can you hold
your arms up for half hour? Yes. Can you hold your breath until you pass
out? Yes. Can you control your heart rate? Yes. But realize how much we
are going against the tide here. And depending on your genetics it can
be a lot harder than for others.

GaryG wrote:
So, we should all just give up then? Look for help through drugs and
surgery?

Neither of which work either. I didn't say give up. But you also have to
have a realistic idea of what your are trying to accomplish.

A wise person once said, "If you think you can, or you think you can't...you
are correct."

I think i can fly by flapping my arms. I must be correct.

GaryG wrote:

We're also genetically programmed to mate like crazy, and to commit homicide
when our territory is threatened. But, most of us manage to control those
instinctual drives.

Neither is close to as strong as the drive to eat. And we do control
them, somewhat poorly. The problem with somewhat poorly controlling
eating is still obesity.

"wendy" wrote in message
...


A wise person once said, "If you think you can, or you think you
can't...you
are correct."

I think i can fly by flapping my arms. I must be correct.


You can fly if you start out high enough, it's the landings that are hell.

--
No Husband Has Ever Been Shot While Doing The Dishes

wendy wrote:
GaryG wrote:
"wendy" wrote in message
...

GaryG wrote:

Well...it's not rocket science either. Losing weight simply
requires consuming a few less calories per day than one burns.

And running a 4 minute mile simply require running a mile under 4
minutes.


Not everyone is able to run a 4-minute mile - it's not physically
possible.

Rubish. It's just mind over matter. Just eat less exercise more. Wait,
that's for weight.

But, it is physically possible for anyone to consume a few less
calories than they burn each day.

And you know this how? As we are just learning about most of these
mechanisms and we are only a generation or two into the world of
plenty without exercise- there's no way for you to know.

There's no way to know that anyone can consume a few less calories than they
burn each day? Nonsense.

All evidence
is going
the other way.

And you know this how? Most who generate this "evidence" aren't even trying.

Many yogis can control their breathing so they can stay
in a coffin for days. It's possible. Can the other 99.999956% of
humanity? Unlikely.

Meaningless.