Glycine

Am J Physiol Regul Integr Comp Physiol. 2004 Aug 26 [Epub ahead of
print] Related Articles, Links
Click here to read
Glycine intake decreases plasma free fatty acids, adipose cell size,
and blood pressure in sucrose-fed rats.

El Hafidi M, Perez I, Zamora J, Soto V, Carvajal-Sandoval G, Banos G.

Bioquimica, Instituto Nacional de Cardiologia (Ignacio Chavez
Mexico, Mexico D.F., Mexico.

The study investigated the mechanism by which glycine protects
against increased circulating nonesterified fatty acids (NEFA), fat cell
size, intra-abdominal fat accumulation, and blood pressure (BP), induced
in male Wistar rats by sucrose-ingestion. The addition of 1% glycine to
the drinking water containing 30% sucrose, for 4 weeks, markedly reduced
high BP in sucrose-fed rats (SFR) (122.3+/-5.6 vs. 147.6+/-5.4 mmHg in
SFR without glycine, p0.05). Decreases in plasma TG levels (0.9+/-0.2
vs. 1.4+/-0.3 mM, p0.001), intra-abdominal fat (8.9+/-3.6 vs 21.2+/-4.9
g, p0.005), and adipose cell size were observed in SFR treated with
glycine, as compared to SFR without treatment. Total NEFA concentration
in the plasma of SFR was significantly decreased by glycine intake
(0.68+/-0.08 vs. 1.11+/-0.09 mM in SFR without glycine p0.001). In
control animals, glycine decreased glucose, TGs, and total NEFA but
without reaching significance. In SFR treated with glycine,
mitochondrial respiration, as an indicator of the rate of fat oxidation,
showed an increase in the state IV oxidation rate of the beta-oxidation
substrates, octanoic acid and palmitoyl-carnitine. This suggests an
enhancement of hepatic fatty acids metabolism, i.e., in their transport,
activation, or beta-oxidation. These findings imply that the protection
by glycine against elevated BP might be attributed to its effect in
increasing fatty acid oxidation, reducing intra-abdominal fat
accumulation and circulating NEFA, which have been proposed as links
between obesity and hypertension.

PMID: 15331379 [PubMed - as supplied by publisher]

"Pouta" wrote in message
om...
Am J Physiol Regul Integr Comp Physiol. 2004 Aug 26 [Epub ahead of
print] Related Articles, Links
Click here to read
Glycine intake decreases plasma free fatty acids, adipose cell size,
and blood pressure in sucrose-fed rats.

El Hafidi M, Perez I, Zamora J, Soto V, Carvajal-Sandoval G, Banos G.

Bioquimica, Instituto Nacional de Cardiologia (Ignacio Chavez
Mexico, Mexico D.F., Mexico.

The study investigated the mechanism by which glycine protects
against increased circulating nonesterified fatty acids (NEFA), fat cell
size, intra-abdominal fat accumulation, and blood pressure (BP), induced
in male Wistar rats by sucrose-ingestion. The addition of 1% glycine to
the drinking water containing 30% sucrose, for 4 weeks, markedly reduced
high BP in sucrose-fed rats (SFR) (122.3+/-5.6 vs. 147.6+/-5.4 mmHg in
SFR without glycine, p0.05). Decreases in plasma TG levels (0.9+/-0.2
vs. 1.4+/-0.3 mM, p0.001), intra-abdominal fat (8.9+/-3.6 vs 21.2+/-4.9
g, p0.005), and adipose cell size were observed in SFR treated with
glycine, as compared to SFR without treatment. Total NEFA concentration
in the plasma of SFR was significantly decreased by glycine intake
(0.68+/-0.08 vs. 1.11+/-0.09 mM in SFR without glycine p0.001). In
control animals, glycine decreased glucose, TGs, and total NEFA but
without reaching significance. In SFR treated with glycine,
mitochondrial respiration, as an indicator of the rate of fat oxidation,
showed an increase in the state IV oxidation rate of the beta-oxidation
substrates, octanoic acid and palmitoyl-carnitine. This suggests an
enhancement of hepatic fatty acids metabolism, i.e., in their transport,
activation, or beta-oxidation. These findings imply that the protection
by glycine against elevated BP might be attributed to its effect in
increasing fatty acid oxidation, reducing intra-abdominal fat
accumulation and circulating NEFA, which have been proposed as links
between obesity and hypertension.

PMID: 15331379 [PubMed - as supplied by publisher]

Us rats will take note.

"Pouta" wrote in message
om...
Am J Physiol Regul Integr Comp Physiol. 2004 Aug 26 [Epub ahead of
print] Related Articles, Links
Click here to read
Glycine intake decreases plasma free fatty acids, adipose cell size,
and blood pressure in sucrose-fed rats.

El Hafidi M, Perez I, Zamora J, Soto V, Carvajal-Sandoval G, Banos G.

Bioquimica, Instituto Nacional de Cardiologia (Ignacio Chavez
Mexico, Mexico D.F., Mexico.

The study investigated the mechanism by which glycine protects
against increased circulating nonesterified fatty acids (NEFA), fat cell
size, intra-abdominal fat accumulation, and blood pressure (BP), induced
in male Wistar rats by sucrose-ingestion. The addition of 1% glycine to
the drinking water containing 30% sucrose, for 4 weeks, markedly reduced
high BP in sucrose-fed rats (SFR) (122.3+/-5.6 vs. 147.6+/-5.4 mmHg in
SFR without glycine, p0.05). Decreases in plasma TG levels (0.9+/-0.2
vs. 1.4+/-0.3 mM, p0.001), intra-abdominal fat (8.9+/-3.6 vs 21.2+/-4.9
g, p0.005), and adipose cell size were observed in SFR treated with
glycine, as compared to SFR without treatment. Total NEFA concentration
in the plasma of SFR was significantly decreased by glycine intake
(0.68+/-0.08 vs. 1.11+/-0.09 mM in SFR without glycine p0.001). In
control animals, glycine decreased glucose, TGs, and total NEFA but
without reaching significance. In SFR treated with glycine,
mitochondrial respiration, as an indicator of the rate of fat oxidation,
showed an increase in the state IV oxidation rate of the beta-oxidation
substrates, octanoic acid and palmitoyl-carnitine. This suggests an
enhancement of hepatic fatty acids metabolism, i.e., in their transport,
activation, or beta-oxidation. These findings imply that the protection
by glycine against elevated BP might be attributed to its effect in
increasing fatty acid oxidation, reducing intra-abdominal fat
accumulation and circulating NEFA, which have been proposed as links
between obesity and hypertension.

PMID: 15331379 [PubMed - as supplied by publisher]

Us rats will take note.

Us rats will take note.

you're not a rat, you're a pig.