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Effect of High-Carbohydrate Feeding on Triglyceride and Saturated Fatty Acid Synthesis
Interesting paper at
http://www.ebmonline.org/cgi/content/full/225/3/178 Effect of High-Carbohydrate Feeding on Triglyceride and Saturated Fatty Acid Synthesis Lisa C. Hudgins1, The Rogosin Institute, Rockefeller University, New York, New York 10021 Abstract It has been known for decades that low-fat, high-carbohydrate diets can increase plasma triglyceride levels, but the mechanism for this effect has been uncertain. Recently, new isotopic and nonisotopic methods have been used to determine in vivo whether low-fat, high-carbohydrate diets increase triglyceride levels by stimulating fatty acid synthesis. The results of a series of studies in lean and obese weight-stable volunteers showed that very-low-fat (10%), high-carbohydrate diets enriched in simple sugars increased the fraction of newly synthesized fatty acids, along with a proportionate increase in the concentration of plasma triglyceride. Furthermore, the concentration of the saturated fatty acid, palmitate, increased and the concentration of the essential polyunsaturated fatty acid, linoleate, decreased in triglyceride and VLDL triglyceride. The magnitude of the increase in triglyceride varied considerably among subjects, was unrelated to sex, body mass index, or insulin levels, and was higher when fatty acid synthesis was constantly elevated rather than having a diurnal variation. It was notable that minimal stimulation of fatty acid synthesis occurred with higher fat diets (30%) or with 10% fat diets enriched in complex carbohydrate. Public health recommendations to reduce dietary fat must take into account the distinct effects of different types of carbohydrate that may increase plasma triglycerides and fatty acid synthesis in a highly variable manner. The mediators and health consequences of this dietary effect deserve further study. ----- I love this part "Furthermore, the concentration of the saturated fatty acid, palmitate, increased and the concentration of the essential polyunsaturated fatty acid, linoleate, decreased in triglyceride and VLDL triglyceride." Bwahaha. Lo fatters avoid all those fats only to have their body make it in its most saturated form and at the expense of good fats. Another good one "It was notable that minimal stimulation of fatty acid synthesis occurred with higher fat diets (30%) or with 10% fat diets enriched in complex carbohydrate." |
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Effect of High-Carbohydrate Feeding on Triglyceride and Saturated Fatty Acid Synthesis
On Mon, 16 Feb 2004 00:58:33 GMT, Charles Henkel wrote:
OK, one more http://www.ebmonline.org/cgi/content/full/225/3/175 Introduction: Low-Saturated Fat, High-Carbohydrate Diets: Effects on Triglyceride and LDL Synthesis, the LDL Receptor, and Cardiovascular Disease Risk Robert H. Knopp, Northwest Lipid Research Clinic, University of Washington, Seattle, Washington 98104 No abstract, but here are some great quotes "This symposium was borne out of the observation that low-fat, high-carbohydrate feeding is associated with an acute increase in plasma triglyceride concentrations." "Because the plasma triglyceride and HDL perturbations of low-fat, high-carbohydrate feeding so resemble the abnormalities associated with Syndrome X or the familial CHL phenotype, we asked in this symposium whether the lipid abnormalities of low-fat, high-carbohydrate feeding might have a similarly negative effect on cardiovascular health." "Should the synthesis of palmitic acid be enhanced during carbohydrate induction, this compensatory effect would have the unwanted effect of cancelling out or subverting the dietary reduction in intake of saturated fat, which is the central goal of the low-fat diet teaching approach." "The Willet paper (16) finally brings the metabolic observations to a level of association with cardiovascular disease employing observational epidemiology. His research indicates that fat restriction per se is not associated with a reduction in coronary artery disease (17). More specifically, the substitution of saturated fat with carbohydrate is associated with no reduction in coronary artery disease whereas substitution of saturated fat with mono- or polyunsaturated acids is associated with a reduction in coronary artery disease in prospective cohort studies (18). As if saturated fat were not bad enough, Dr. Willet's studies point to the fact that trans fatty acids cause even greater increases in LDL cholesterol concentrations than saturated fat and reduce HDL cholesterol and increase Lp(a) concentrations. " |
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