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#1
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Why a high-carb diet can kill...
Asia Pac J Clin Nutr. 2005;14 Suppl:S120.
High glycemic index carbohydrate mediates an acute proinflammatory process as measured by NF-kappaB activation. Dickinson S, Hancock DP, Petocz P, Brand-Miller JC. School of Molecular and Microbial Biosciences, University of Sydney, NSW, 2006. Background - Some high-carbohydrate diets may increase the risk of cardiovascular disease (CVD) by promoting hyperglycemia, oxidative stress, endothelial dysfunction and low-grade inflammation. In this context, the classification of carbohydrates according to their postprandial effects (ie the glycemic index, GI) may be relevant to prevention and management of CVD. Objectives - The present study was designed to detect differences in postprandial NF-kappaB activation (an acute inflammatory marker) in mononuclear cells and nitrotyrosine levels (a marker of oxidative stress) after high vs low GI meals in 10 lean, young, healthy European Caucasian subjects (5 male, 5 female) matched for age, BMI, waist circumference, diet and physical activity. Design - A 50 g portion of a high GI (white bread) was compared with an isoenergetic, macronutrient-matched portion of a low GI food (pasta) consumed in random order after an overnight fast. Glycaemia, insulinemia, NF-kappaB and nitrotyrosine levels were determined at 0, 60, 120 and 180 min and quantitated using the area under the curve (AUC). Outcome - Glycemia and insulinemia were within the normal range but 3- and nearly 4-fold higher respectively after the bread meal compared with the pasta meal. As hypothesised, the NF-kappaB response was 3-fold greater after the bread meal (mean +/- SEM: 69 +/- 16 optical density (OD) h) compared with the pasta meal (23 +/- 4.7 OD h). Nitrotyrosine levels increased after the bread meal (0.67 +/- 0.49 nmoles/L) and decreased after the pasta (-0.81 +/- 0.30 nmoles/L) but the difference did not reach statistical significance. Conclusion - The present study shows that high GI carbohydrate, but not low GI carbohydrate, mediates an acute proinflammatory process as measured by NF-kappaB activity. Blunting postprandial glycemia via low GI carbohydrate may lower CVD risk. PMID: 16326481 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/q...81&query_hl=16 |
#2
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Why a high-carb diet can kill...
On Wed, 07 Dec 2005 19:02:59 GMT, "Katt" wrote:
Asia Pac J Clin Nutr. 2005;14 Suppl:S120. High glycemic index carbohydrate mediates an acute proinflammatory process as measured by NF-kappaB activation. Dickinson S, Hancock DP, Petocz P, Brand-Miller JC. School of Molecular and Microbial Biosciences, University of Sydney, NSW, 2006. Background - Some high-carbohydrate diets may increase the risk of cardiovascular disease (CVD) by promoting hyperglycemia, oxidative stress, endothelial dysfunction and low-grade inflammation. In this context, the classification of carbohydrates according to their postprandial effects (ie the glycemic index, GI) may be relevant to prevention and management of CVD. Objectives - The present study was designed to detect differences in postprandial NF-kappaB activation (an acute inflammatory marker) in mononuclear cells and nitrotyrosine levels (a marker of oxidative stress) after high vs low GI meals in 10 lean, young, healthy European Caucasian subjects (5 male, 5 female) matched for age, BMI, waist circumference, diet and physical activity. Design - A 50 g portion of a high GI (white bread) was compared with an isoenergetic, macronutrient-matched portion of a low GI food (pasta) consumed in random order after an overnight fast. Glycaemia, insulinemia, NF-kappaB and nitrotyrosine levels were determined at 0, 60, 120 and 180 min and quantitated using the area under the curve (AUC). Outcome - Glycemia and insulinemia were within the normal range but 3- and nearly 4-fold higher respectively after the bread meal compared with the pasta meal. As hypothesised, the NF-kappaB response was 3-fold greater after the bread meal (mean +/- SEM: 69 +/- 16 optical density (OD) h) compared with the pasta meal (23 +/- 4.7 OD h). Nitrotyrosine levels increased after the bread meal (0.67 +/- 0.49 nmoles/L) and decreased after the pasta (-0.81 +/- 0.30 nmoles/L) but the difference did not reach statistical significance. Conclusion - The present study shows that high GI carbohydrate, but not low GI carbohydrate, mediates an acute proinflammatory process as measured by NF-kappaB activity. Blunting postprandial glycemia via low GI carbohydrate may lower CVD risk. May lower risk..so what have we learned here? Nothing |
#3
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Why a high-carb diet can kill...
"Katt" wrote in message news Asia Pac J Clin Nutr. 2005;14 Suppl:S120. High glycemic index carbohydrate mediates an acute proinflammatory process as measured by NF-kappaB activation. Dickinson S, Hancock DP, Petocz P, Brand-Miller JC. School of Molecular and Microbial Biosciences, University of Sydney, NSW, 2006. Background - Some high-carbohydrate diets may increase the risk of Cuting and pasting stuff you know nothing about may also kill! |
#4
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Why a high-carb diet can kill...
Low carb diets have their own risk profile.
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#5
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Why a high-carb diet can kill...
Low carb diets have their own risk profile. The world is not black
and white. As an example, (healthy) internal organs depicted in medical textbooks are not representative of ALL (healthy) internal organs. They come in all shapes and sizes! |
#6
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Why a high-carb diet can kill...
On Wed, 07 Dec 2005 16:17:58 -0500, Susan
wrote: On the contrary, there are a zillion studies demonstrating that higher glycemic load diets promote heart disease, certain cancers, insulin resistance, diabetes and inflammation. Yes zillions of studies and now another one that shows us what? The same thing. Whole grains are better than refined flour. It has already been shown that one can live a long healthy life on a diet consisting primarily on carbs that are unrefined. In human nutrition, there is no essential carbohydrate, only essential fats and proteins. Yes we have already heard this from TC and yes there is no essential carb as any carb will do but they are needed as a macronutirent and better that they are healthy carbs than from poptarts. |
#7
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Why a high-carb diet can kill...
Glassman wrote:
|| "Katt" wrote in message || news ||| Asia Pac J Clin Nutr. 2005;14 Suppl:S120. ||| ||| High glycemic index carbohydrate mediates an acute proinflammatory ||| process as measured by NF-kappaB activation. ||| ||| Dickinson S, Hancock DP, Petocz P, Brand-Miller JC. ||| ||| School of Molecular and Microbial Biosciences, University of Sydney, ||| NSW, 2006. ||| ||| Background - Some high-carbohydrate diets may increase the risk of ||| || || Cuting and pasting stuff you know nothing about may also kill! HUH???????? -- Peter Website: http://users.thelink.net/marengo |
#8
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Why a high-carb diet can kill...
On Wed, 07 Dec 2005 21:45:07 -0500, Susan
wrote: Yes we have already heard this from TC and yes there is no essential carb as any carb will do but they are needed as a macronutirent and better that they are healthy carbs than from poptarts. No, they are not needed as a macronutrient. Look up "essential" as it pertains to human nutrition. Only fat and protein are needed. Try running a marathon or even 5 miles a day and tell me carbs are not needed. Either one is not equivalent with what early man needed for energy. |
#9
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Why a high-carb diet can kill...
"jt" wrote in message
... Try running a marathon or even 5 miles a day and tell me carbs are not needed. Either one is not equivalent with what early man needed for energy. Humans can adapt readily to do things like running 5 miles on pretty much any type of diet, including one that is very low in CHO. There is reason for this, in that some of our ancestors in northern climates would have had to subsist primarily on game, during cold times of year when fruit was not available and limited stores of seeds and similar were used up. This is confirmed by all the low-carbers who are quite able to exercise, even for long periods of time, on a low-carb diet. This does appear to require a period of adaptation, however, especially for someone who has been eating a high-CHO diet for a lifetime. Personally, I found I had better stamina on a low-CHO diet than on a high-CHO diet. Granted I was doing moderate-intensity aerobic exercise, but my stamina was definitely enhanced. In the past there's been some good information posted in both asdl-c and smn about low-CHO training-based enhancement of the body's abilility to store and use fatty acids for muscular activity There's no question that increasing CHO intake can enhance performance for many, especially for high-intensity anaerobic activities, including repeated lifting of heavy weights. But an adapted individual can still do quite well with a relatively low CHO intake. HG |
#10
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Why a high-carb diet can kill...
"Susan" wrote in message
... jt wrote: Yes zillions of studies and now another one that shows us what? Huh? Well, Susan, apparently not everyone is interested in seeing yet another mechanism demonstrated. 8-) Personally I found the abstract really interesting. There's been a lot of talk for the last few years about the importance of inflammation in development of coronary heart disease. The studies coming along that indicate various ways inflammation occurs are, to my mind, pretty important. But that's just me. HG |
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