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#1
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CLA helps destroy fat cells, helps with insuiln sensitivity
On 16 Jul 2004 19:52:34 GMT, Ignoramus22273
wrote: Here's two interesting articles, all related to how certain safe nutritional supplements help destroy fat cells, and maintain level of beta cells responsible for insulin production. It works very well in rodents. If you're a mouse, you should take it. If not, read the studies on humans. CLA doesn't have any significant effect of those. Barbara Hirsch, Publisher OBESITY MEDS AND RESEARCH NEWS The latest in obesity research and weight loss drug development http://www.obesity-news.com/ |
#2
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CLA helps destroy fat cells, helps with insuiln sensitivity
On 16 Jul 2004 19:52:34 GMT, Ignoramus22273
wrote: Here's two interesting articles, all related to how certain safe nutritional supplements help destroy fat cells, and maintain level of beta cells responsible for insulin production. It works very well in rodents. If you're a mouse, you should take it. If not, read the studies on humans. CLA doesn't have any significant effect of those. Barbara Hirsch, Publisher OBESITY MEDS AND RESEARCH NEWS The latest in obesity research and weight loss drug development http://www.obesity-news.com/ |
#3
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CLA helps destroy fat cells, helps with insuiln sensitivity
On Fri, 16 Jul 2004 20:13:41 GMT, Barbara Hirsch w
It works very well in rodents. If you're a mouse, you should take it. If not, read the studies on humans. CLA doesn't have any significant effect of those. Here's a study that says CLA works very well on humans: http://biz.yahoo.com/prnews/040520/dcw047a_1.html |
#4
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CLA helps destroy fat cells, helps with insuiln sensitivity
On Fri, 16 Jul 2004 20:13:41 GMT, Barbara Hirsch w
It works very well in rodents. If you're a mouse, you should take it. If not, read the studies on humans. CLA doesn't have any significant effect of those. Here's a study that says CLA works very well on humans: http://biz.yahoo.com/prnews/040520/dcw047a_1.html |
#5
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CLA helps destroy fat cells, helps with insuiln sensitivity
One dark day on Usenet, Barbara Hirsch said:
On 16 Jul 2004 19:52:34 GMT, Ignoramus22273 wrote: Here's two interesting articles, all related to how certain safe nutritional supplements help destroy fat cells, and maintain level of beta cells responsible for insulin production. It works very well in rodents. If you're a mouse, you should take it. If not, read the studies on humans. CLA doesn't have any significant effect of those. What the dickens *is* CLA, anyway..? -- J.J. in WA * 275/231/225 (mini) (COLD to HOT for e-mail) |
#6
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CLA helps destroy fat cells, helps with insuiln sensitivity
One dark day on Usenet, Barbara Hirsch said:
On 16 Jul 2004 19:52:34 GMT, Ignoramus22273 wrote: Here's two interesting articles, all related to how certain safe nutritional supplements help destroy fat cells, and maintain level of beta cells responsible for insulin production. It works very well in rodents. If you're a mouse, you should take it. If not, read the studies on humans. CLA doesn't have any significant effect of those. What the dickens *is* CLA, anyway..? -- J.J. in WA * 275/231/225 (mini) (COLD to HOT for e-mail) |
#7
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CLA helps destroy fat cells, helps with insuiln sensitivity
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#8
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CLA helps destroy fat cells, helps with insuiln sensitivity
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#9
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CLA helps destroy fat cells, helps with insuiln sensitivity
On Fri, 16 Jul 2004 20:18:35 GMT, none@ (Sped) wrote:
Here's a study that says CLA works very well on humans: http://biz.yahoo.com/prnews/040520/dcw047a_1.html That's not a study, it's a press release. However, I took a look at the original study. In the first place, the "significant decline in body weight " in the CLA group was a baseline BMI of 28.1 ± 1.5 and 27.7 ± 1.7 at the end of a year. Baseline body fat was 31.6 ± 5.2 and at the end of a year it was 29.9 ± 5.6.. There was no change in LBM. The study was also supported by Natural LTD and Cognis Nutrition and Health. Cognis Nutrition supplies the raw materials for Tonalin CLA. So the independence of this study is questionable. Here are two recent reviews of the literature that describe the effect of cla on humans as minimal: Effect of conjugated linoleic acid on body composition and plasma lipids in humans: an overview of the literature. Terpstra AH. Am J Clin Nutr. 2004 Mar;79(3):352-61. From the results section: Body weight and composition All the studies indicated that the administration of CLA had no significant effect on body weight or body weight regain. After correction for changes in body weight in the control groups, there was a net increase in body weight due to CLA in the body weight regain study by Kamphuis et al, and this increase ranged from 0.6 to 2.0 kg. In the other studies, the corrected net change in body weight ranged from an increase of 0.4 kg to a decrease of 2.2 kg. None of these changes, however, were significant There was a significant effect of CLA on body fat mass in only 2 studies. This effect could not be ascribed to a higher intake of CLA in these studies than in the other studies, and there appeared to be no relation between the dose of trans-10, cis-12 isomer, the isomer involved in the body fat-lowering effect, and the body fat-lowering effect. Furthermore, in these 2 studies that reported a significant body fat-lowering effect of CLA, the subjects also participated in a light or intensive training program or did 90 min of strenuous exercise 3 times/wk. Thus, it is possible that exercise may have enhanced the body fat-lowering effect of CLA. In the studies by Berven et al, Blankson et al, and Thom et al, the net decrease in body fat tended to be greater than the net decrease in body weight, and in the study by Smedman and Vessby, there was a slight net increase in body weight but a net decrease in body fat. This finding indicates that in these studies, a change took place not only in body fat but also in lean body mass (LBM). A net decrease in body fat that was greater than the net decrease in body weight indicates that there was an increase in LBM or that the decrease in LBM was less than that in the control group, as seen in the study by Berven et al. Furthermore, in the weight regain study by Kamphuis et al, CLA tended to promote body weight regain after a weight-loss regimen, and this net increase in body weight was predominantly due to an increase in LBM. See also: Efficacy and safety of dietary supplements containing CLA for the treatment of obesity: evidence from animal and human studies. Larsen TM, et al. J Lipid Res. 2003 Dec;44(12):2234-41. Epub 2003 Aug 16. From the results section: No effect of CLA consumption on body weight was found in any of the 13 studies. FM was assessed in 10 studies, and three of these found a decrease in FM. Fat-free mass (FFM) was assessed in seven studies, but only one of these studies found a slight increase in body FFM (FFM assumed to correspond to lean body mass). Three studies assessed neither FM nor FFM. With respect to cardiovascular risk factors, either no or very small changes in cholesterol levels were reported, and no consistent changes were observed. Only one study included direct insulin sensitivity measurements. In this study by Riserus et al., for 12 weeks, supplementation with 3.4 g/day of purified (75%) t10,c12 resulted in a significant decrease in insulin sensitivity (using an intravenous glucose tolerance test), an increase in fasting plasma glucose, and a significant increase in the concentration of C-reactive protein, a marker of inflammation and a strong predictor of cardiovascular risk. CLA supplementation in humans has been shown to increase urinary levels of 8-iso-PGF2-a and 15-keto-dihydro-PGF2-a, which are in vivo markers of nonenzymatic and enzymatic lipid peroxidation and oxidative stress, processes that may contribute to insulin resistance. To summarize, the present data from human trials does not support any weight loss-inducing effect of CLA, and there is no unequivocal evidence of an effect on body fat percentage. In addition, it seems that CLA may actually induce adverse effects, including insulin resistance, in subjects susceptible to type 2 diabetes. I wrote a review of my own a couple of years ago which found the same thing that these researchers did. FWIW, Barbara Hirsch, Publisher OBESITY MEDS AND RESEARCH NEWS The latest in obesity research and weight loss drug development http://www.obesity-news.com/ |
#10
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CLA helps destroy fat cells, helps with insuiln sensitivity
On Sat, 17 Jul 2004 01:25:52 GMT, Barbara Hirsch
wrote: On Fri, 16 Jul 2004 20:18:35 GMT, none@ (Sped) wrote: Here's a study that says CLA works very well on humans: http://biz.yahoo.com/prnews/040520/dcw047a_1.html That's not a study, it's a press release. It's not a press release, it's a story in a mainstream news source about a study showing that CLA helps overweight people lose fat. You can follow the links and read the actual study for yourself. |
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