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#21
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Splenda tablets - Why can't Johnson & Johnson sell them in the US?
Here are some very nice refernces...
Hsieh MH, Chan P, Sue YM, Liu JC, Liang TH, Huang TY, Tomlinson B, Chow MS, Kao PF, Chen YJ. Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: A two-year, randomized, placebo-controlled study. Clin Ther. 2003 Nov;25(11):2797-808. PMID: 14693305 [PubMed - in process] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=146933 05&dopt=Abstract Chan P, Tomlinson B, Chen YJ, Liu JC, Hsieh MH, Cheng JT. A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension. Br J Clin Pharmacol. 2000 Sep;50(3):215-20. PMID: 10971305 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=109713 05&dopt=Abstract Lee CN, Wong KL, Liu JC, Chen YJ, Cheng JT, Chan P. Inhibitory effect of stevioside on calcium influx to produce antihypertension. Planta Med. 2001 Dec;67(9):796-9. PMID: 11745013 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=117450 13&dopt=Abstract Liu JC, Kao PK, Chan P, Hsu YH, Hou CC, Lien GS, Hsieh MH, Chen YJ, Cheng JT. Mechanism of the antihypertensive effect of stevioside in anesthetized dogs. Pharmacology. 2003 Jan;67(1):14-20. PMID: 12444299 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=124442 99&dopt=Abstract Jeppesen PB, Gregersen S, Rolfsen SE, Jepsen M, Colombo M, Agger A, Xiao J, Kruhoffer M, Orntoft T, Hermansen K. Antihyperglycemic and blood pressure-reducing effects of stevioside in the diabetic Goto-Kakizaki rat. Metabolism. 2003 Mar;52(3):372-8. PMID: 12647278 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=126472 78&dopt=Abstract Geuns JM. Stevioside. Phytochemistry. 2003 Nov;64(5):913-21. PMID: 14561506 [PubMed - in process] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=145615 06&dopt=Abstract Gregersen S, Jeppesen PB, Holst JJ, Hermansen K. Antihyperglycemic effects of stevioside in type 2 diabetic subjects. Metabolism. 2004 Jan;53(1):73-6. PMID: 14681845 [PubMed - in process] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=146818 45&dopt=Abstract Jeppesen PB, Gregersen S, Alstrup KK, Hermansen K. Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic effects in vivo: studies in the diabetic Goto-Kakizaki (GK) rats. Phytomedicine. 2002 Jan;9(1):9-14. PMID: 11924770 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=119247 70&dopt=Abstract Herbal tea lowers blood pressure, say doctors The China Post, Monday, April 2, 2001 URL:http://www.taiwanheadlines.gov.tw/20010402/20010402s6.html The Nutraceutical Corner.........Stevia: A Sweet Choice for Some URL:http://sun.science.wayne.edu/~nfs/news/basfsp00.htm#Stevia Stevia Sweetener, a Sugar Alternative URL:http://nutrition.about.com/library/weekly/aa092099.htm Stevia Research URL:http://herbsforhealth.about.com/cs/herbsasfood/a/aa121997_2.htm Stevia : by Ray Sahelian MD , stevia sweetener stevia recipes stevia cooking URL:http://www.raysahelian.com/stevia.html Stevia, Herb Monograph - Flora Health Herb Encyclopedia URL:http://www.florahealth.com/flora/home/canada/healthinformation/encyclopedias/Stevia.asp Monograph : Stevia rebaudiana (requires free registration) URL:http://www.phytotherapies.org/monograph_detail.cfm?id=262 Medicinal herbFAQ Part 2/7 (scroll down the page to find Stevia) URL:http://www.faqs.org/faqs/medicinal-herbs/part2/ Stevia rebaudiana URL:http://www.rain-tree.com/stevia.htm Stevia - The Natural Sweetener URL:http://www.healthy.net/nutrit/kitchen/foods/stevia.asp Stevia - Frequently asked questions URL:http://www.stepa.be/faqs.html How Sweet Is Stevia URL:http://www.life.ca/nl/83/stevia.html -- Winning against heart attack and stroke http://www.sonoscore.com |
#22
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Splenda tablets - Why can't Johnson & Johnson sell them in the US?
Fri, 19 Mar 2004 23:10:33 GMT in article
"Evelyn Ruut" wrote: Sonos, Stevia tastes nasty. And yes, there are some very negative reports about it. Could you mention some? BTW, I don't think stevia tastes nasty, but de gustibus non est disputandum. -- Matti Narkia |
#23
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Splenda tablets - Why can't Johnson & Johnson sell them in the US?
On 19-Mar-2004, Vicki Beausoleil wrote: http://www.foodstandards.gov.uk enter stevia into the search engine. I did. Thanks. Like the FDA, your link is to a government agency who must also contend with lobby efforts of a multibillion dollar industy. -- Winning against heart attack and stroke http://www.sonoscore.com |
#24
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Splenda tablets - Why can't Johnson & Johnson sell them in the US?
"Matti Narkia" wrote in message ... Fri, 19 Mar 2004 23:10:33 GMT in article "Evelyn Ruut" wrote: Sonos, Stevia tastes nasty. And yes, there are some very negative reports about it. Could you mention some? BTW, I don't think stevia tastes nasty, but de gustibus non est disputandum. It surely doesn't taste as good as Splenda. I threw out a whole bottle of Stevia when I got that. -- Evelyn (To reply to me personally, remove sox) -- Matti Narkia |
#25
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Splenda tablets - Why can't Johnson & Johnson sell them in the US?
I mix unsweetened baking cocoa with stevia into soy milk and really like it.
http://www.ghirardelli.com/products_bakecocoa2.html http://www.iherb.com/steviabalance.html -- Winning against heart attack and stroke http://www.sonoscore.com |
#26
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Splenda tablets - Why can't Johnson & Johnson sell them in the US?
"Julie Bove" wrote in message ... "hba1c" wrote in message om... As you may know, Splenda is available in a tablet form in many countries. snip I didn't know, but I would also have no use for them. If I do use Splenda, it is in cooking. Couldn't use tablets there! -- Type 2 http://users.bestweb.net/~jbove/ Of course you can. just crush them. Sid... |
#27
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Splenda tablets - Why can't Johnson & Johnson sell them in theUS?
Sonos wrote:
why not try stevia instead? Splenda is a sugar molecule with a chlorine pasted on it. A tasty invention, but is it safe? Combining atoms into molecules changes their physical properties. Sodium and Chloride are both toxic to humans, yet we sprinkle salt on our food all the time. E |
#28
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Splenda tablets - Why can't Johnson & Johnson sell them in the US?
"sprudil" wrote in message news:qdM6c.109554$Up2.74269@pd7tw1no... "Julie Bove" wrote in message ... "hba1c" wrote in message om... As you may know, Splenda is available in a tablet form in many countries. snip I didn't know, but I would also have no use for them. If I do use Splenda, it is in cooking. Couldn't use tablets there! -- Type 2 http://users.bestweb.net/~jbove/ Of course you can. just crush them. Why bother? Too much trouble to do that. -- Type 2 http://users.bestweb.net/~jbove/ |
#29
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Splenda tablets - Why can't Johnson & Johnson sell them in the US?
On Sat, 20 Mar 2004 00:27:02 GMT, "sprudil" wrote:
"Julie Bove" wrote in message ... I didn't know, but I would also have no use for them. If I do use Splenda, it is in cooking. Couldn't use tablets there! Of course you can. just crush them. Sid... Yep, I do that all the time. My first choice is using a zero-carb liquid splenda syrup, but if there's reason not to add additional liquid to a recipe, I'll crush the tablets with the back of a spoon. Since they're just 0.07 g carb per tablet, they're a lot better than using the powdered stuff. Em |
#30
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Splenda tablets - Why can't Johnson & Johnson sell them in the US?
Fri, 19 Mar 2004 18:31:33 -0500 in article
Vicki Beausoleil wrote: Julie Bove wrote: "Sonos" wrote in message news Stevia has been used for over 1,500 years by young and old people, including pregnant women without any report of harm to my knowledge. This alone make me feel more comfortable using it. Sucralose is new however. Too new for me to feel comfortable with it. snip Ah, the "to my knowledge" is the key part. Stick your head in the sand and you won't learn much. And do you really think we are stupid enough to believe anything at the Mercola site? -- Type 2 http://users.bestweb.net/~jbove/ Julie, if the Mercola site forecast sunshine in the desert, I'd bring my umbrella. http://www.foodstandards.gov.uk enter stevia into the search engine. Read and learn. Learn why stevia is banned in the European Union and other places. Learn what happens to reproductive organs in the male. Learn what happens to mitochondria when exposed to stevioside. As far as I understand some negative effects have been produced in rodents by giving them gigantic doses of steviol or stevioside. Even so, conflicting results have also been produced. Some studies suggest that stevia and stevioside have antiglycemic, antihypertensive, antiviral and even anticancer effects, although cancer has also been observed in rodents in connection with gigantic doses. In general, it seems that no negative effects have been proven with the doses applicable for human consumption. EU's stand seems to be that because some negative effects have been noticed with huge doses, stevia should not be permitted until its safety has been proven more convincingly. Here a couple of links found from the web site you provided: URL:http://www.foodstandards.gov.uk/news/pressreleases/stevioside A citation: "An application to market a component of the leaves known as Stevioside was also rejected by the Commission on safety grounds. Stevioside has been shown to decrease fertility in male rats. Additionally, Steviol, which is a metabolite of Stevioside, has been reported to cause cancer when fed at very high doses to rodents (up to 1000mg per kg of body weight - this is 1500 times greater than the average daily dose of these products consumed by a person weighing 60kg)." URL:http://www.foodstandards.gov.uk/multimedia/webpage/stevia A couple of excerpts: "The data considered by the Committee indicated that the extract has the potential to produce adverse effects in the male reproductive system that could affect fertility and that a metabolite produced by the human gut microflora, steviol, is genotoxic (ie. damages DNA). [...] The ACNFP agreed with the opinion of the Belgian Authorities and recommended that the product should not be approved due to lack of information supporting its safety, a view that was shared by a number of other Member States. The application was subsequently referred to the SCF. The SCF concluded in June 1999 that the information submitted on the plant products was insufficient with regard to specification and standardisation of the commercial product and contained no safety studies." On this page there is also a link to this letter: URL:http://archive.food.gov.uk/maff/archive/food/novel/stevreb.htm Below a rather comprehensive collection of stevia related Medline references: Toxicology references --------------------- Hagiwara A, Fukushima S, Kitaori M, Shibata M, Ito N. Effects of three sweeteners on rat urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)-nitrosamine. Gann. 1984 Sep;75(9):763-8. PMID: 6500232 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&li st_uids=6500232 Ito N, Fukushima S, Shirai T, Hagiwara A, Imaida K. Drugs, food additives and natural products as promoters in rat urinary bladder carcinogenesis. IARC Sci Publ. 1984;(56):399-407. PMID: 6536604 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&li st_uids=6536604 Xili L, Chengjiany B, Eryi X, Reiming S, Yuengming W, Haodong S, Zhiyian H. Chronic oral toxicity and carcinogenicity study of stevioside in rats. Food Chem Toxicol. 1992 Nov;30(11):957-65. PMID: 1473789 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&li st_uids=1473789 Aze Y, Toyoda K, Imaida K, Hayashi S, Imazawa T, Hayashi Y, Takahashi M. [Subchronic oral toxicity study of stevioside in F344 rats] Eisei Shikenjo Hokoku. 1991;(109):48-54. Japanese. PMID: 1364404 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&li st_uids=1364404 Matsui M, Matsui K, Kawasaki Y, Oda Y, Noguchi T, Kitagawa Y, Sawada M, Hayashi M, Nohmi T, Yoshihira K, Ishidate M Jr, Sofuni T. Evaluation of the genotoxicity of stevioside and steviol using six in vitro and one in vivo mutagenicity assays. Mutagenesis. 1996 Nov;11(6):573-9. PMID: 8962427 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=896242 7&dopt=Abstract Matsui M, Matsui K, Nohmi T, Mizusawa H, Ishidate M. [Mutagenicity of steviol: an analytical approach using the Southern blotting system] Eisei Shikenjo Hokoku. 1989;(107):83-7. Japanese. PMID: 2700079 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&li st_uids=2700079 Klongpanichpak S, Temcharoen P, Toskulkao C, Apibal S, Glinsukon T. Lack of mutagenicity of stevioside and steviol in Salmonella typhimurium TA 98 and TA 100. J Med Assoc Thai. 1997 Sep;80 Suppl 1:S121-8. PMID: 9347659 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=934765 9&dopt=Abstract Suttajit M, Vinitketkaumnuen U, Meevatee U, Buddhasukh D. Mutagenicity and human chromosomal effect of stevioside, a sweetener from Stevia rebaudiana Bertoni. Environ Health Perspect. 1993 Oct;101 Suppl 3:53-6. PMID: 8143647 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&li st_uids=8143647 Procinska E, Bridges BA, Hanson JR. Interpretation of results with the 8-azaguanine resistance system in Salmonella typhimurium: no evidence for direct acting mutagenesis by 15-oxosteviol, a possible metabolite of steviol. Mutagenesis. 1991 Mar;6(2):165-7. PMID: 2056919 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&li st_uids=2056919 Yodyingyuad V, Bunyawong S. Effect of stevioside on growth and reproduction. Hum Reprod. 1991 Jan;6(1):158-65. PMID: 1874950 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&li st_uids=1874950 Sekihashi K, Saitoh H, Sasaki Y. [Genotoxicity studies of stevia extract and steviol by the comet assay] J Toxicol Sci. 2002 Dec;27 Suppl 1:1-8. Japanese. PMID: 12533916 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=125339 16&dopt=Abstract Toyoda K, Matsui H, Shoda T, Uneyama C, Takada K, Takahashi M. Assessment of the carcinogenicity of stevioside in F344 rats. Food Chem Toxicol. 1997 Jun;35(6):597-603. PMID: 9225018 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&li st_uids=9225018 Toskulkao C, Chaturat L, Temcharoen P, Glinsukon T. Acute toxicity of stevioside, a natural sweetener, and its metabolite, steviol, in several animal species. Drug Chem Toxicol. 1997 Feb-May;20(1-2):31-44. PMID: 9183561 [PubMed - indexed for MEDLINE URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&li st_uids=9183561 Krejci ME, Koechel DA. Acute effects of carboxyatractyloside and stevioside, inhibitors of mitochondrial ADP/ATP translocation, on renal function and ultrastructure in pentobarbital-anesthetized dogs. Toxicology. 1992;72(3):299-313. PMID: 1585384 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&li st_uids=1585384 Wasuntarawat C, Temcharoen P, Toskulkao C, Mungkornkarn P, Suttajit M, Glinsukon T. Developmental toxicity of steviol, a metabolite of stevioside, in the hamster. Drug Chem Toxicol. 1998 May;21(2):207-22. PMID: 9598301 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&li st_uids=9598301 Usami M, Sakemi K, Kawashima K, Tsuda M, Ohno Y. [Teratogenicity study of stevioside in rats] Eisei Shikenjo Hokoku. 1995;(113):31-5. Japanese. PMID: 8717225 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&li st_uids=8717225 Sekihashi K, Saitoh H, Sasaki Y. [Genotoxicity studies of stevia extract and steviol by the comet assay] J Toxicol Sci. 2002 Dec;27 Suppl 1:1-8. Japanese. PMID: 12533916 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=125339 16&dopt=Abstract Yasukawa K, Kitanaka S, Seo S. Inhibitory effect of stevioside on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. Biol Pharm Bull. 2002 Nov;25(11):1488-90. PMID: 12419967 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=124199 67&dopt=Abstract Geuns JM, Bruggeman V, Buyse JG. Effect of stevioside and steviol on the developing broiler embryos. J Agric Food Chem. 2003 Aug 13;51(17):5162-7. PMID: 12903985 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&li st_uids=12903985 Braguini WL, Gomes MA, de Oliveira BH, Carnieri EG, Rocha ME, de Oliveira MB. Activity of isosteviol lactone on mitochondrial metabolism. Toxicol Lett. 2003 Jun 5;143(1):83-92. PMID: 12697384 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&li st_uids=12697384 Melis MS. Effects of chronic administration of Stevia rebaudiana on fertility in rats. J Ethnopharmacol. 1999 Nov 1;67(2):157-61. PMID: 10619379 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=106193 79&dopt=Abstract Oliveira-Filho RM, Uehara OA, Minetti CA, Valle LB. Chronic administration of aqueous extract of Stevia rebaudiana (Bert.) Bertoni in rats: endocrine effects. Gen Pharmacol. 1989;20(2):187-91. PMID: 2785472 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&li st_uids=2785472 Schvartzman JB, Krimer DB, Moreno Azorero R. Cytological effects of some medicinal plants used in the control of fertility. Experientia. 1977 May 15;33(5):663-5. PMID: 862810 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&li st_uids=862810 Aritajat S, Kaweewat K, Manosroi J, Manosroi A. Dominant lethal test in rats treated with some plant extracts. Southeast Asian J Trop Med Public Health. 2000;31 Suppl 1:171-3. PMID: 11414451 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&li st_uids=11414451 Chemistry reference ------------------- Geuns JM. Stevioside. Phytochemistry. 2003 Nov;64(5):913-21. PMID: 14561506 [PubMed - in process] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=145615 06&dopt=Abstract Antiglycemic & antihypertensive effects related references ---------------------------------------------------------- Jeppesen PB, Gregersen S, Rolfsen SE, Jepsen M, Colombo M, Agger A, Xiao J, Kruhoffer M, Orntoft T, Hermansen K. Antihyperglycemic and blood pressure-reducing effects of stevioside in the diabetic Goto-Kakizaki rat. Metabolism. 2003 Mar;52(3):372-8. PMID: 12647278 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=126472 78&dopt=Abstract Liu JC, Kao PK, Chan P, Hsu YH, Hou CC, Lien GS, Hsieh MH, Chen YJ, Cheng JT. Mechanism of the antihypertensive effect of stevioside in anesthetized dogs. Pharmacology. 2003 Jan;67(1):14-20. PMID: 12444299 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=124442 99&dopt=Abstract Hsu YH, Liu JC, Kao PF, Lee CN, Chen YJ, Hsieh MH, Chan P. Antihypertensive effect of stevioside in different strains of hypertensive rats. Zhonghua Yi Xue Za Zhi (Taipei). 2002 Jan;65(1):1-6. PMID: 11939668 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=119396 68&dopt=Abstract Jeppesen PB, Gregersen S, Alstrup KK, Hermansen K. Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic effects in vivo: studies in the diabetic Goto-Kakizaki (GK) rats. Phytomedicine. 2002 Jan;9(1):9-14. PMID: 11924770 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=119247 70&dopt=Abstract Lee CN, Wong KL, Liu JC, Chen YJ, Cheng JT, Chan P. Inhibitory effect of stevioside on calcium influx to produce antihypertension. Planta Med. 2001 Dec;67(9):796-9. PMID: 11745013 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=117450 13&dopt=Abstract Jeppesen PB, Gregersen S, Poulsen CR, Hermansen K. Stevioside acts directly on pancreatic beta cells to secrete insulin: actions independent of cyclic adenosine monophosphate and adenosine triphosphate-sensitive K+-channel activity. Metabolism. 2000 Feb;49(2):208-14. PMID: 10690946 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=106909 46&dopt=Abstract Chan P, Xu DY, Liu JC, Chen YJ, Tomlinson B, Huang WP, Cheng JT. The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats. Life Sci. 1998;63(19):1679-84. PMID: 9806223 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=980622 3&dopt=Abstract Toskulkao C, Sutheerawattananon M, Piyachaturawat P. Inhibitory effect of steviol, a metabolite of stevioside, on glucose absorption in everted hamster intestine in vitro. Toxicol Lett. 1995 Oct;80(1-3):153-9. PMID: 7482583 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&li st_uids=7482583 Melis MS. A crude extract of Stevia rebaudiana increases the renal plasma flow of normal and hypertensive rats. Braz J Med Biol Res. 1996 May;29(5):669-75. PMID: 9033821 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=903382 1&dopt=Abstract Lailerd N, Saengsirisuwan V, Sloniger JA, Toskulkao C, Henriksen EJ. Effects of stevioside on glucose transport activity in insulin-sensitive and insulin-resistant rat skeletal muscle. Metabolism. 2004 Jan;53(1):101-7. PMID: 14681850 [PubMed - in process] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=146818 50&dopt=Abstract Wong KL, Chan P, Yang HY, Hsu FL, Liu IM, Cheng YW, Cheng JT. Isosteviol acts on potassium channels to relax isolated aortic strips of Wistar rat. Life Sci. 2004 Mar 26;74(19):2379-87. PMID: 14998715 [PubMed - in process] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&li st_uids=14998715 Wong KL, Yang HY, Chan P, Cheng TH, Liu JC, Hsu FL, Liu IM, Cheng YW, Cheng JT. Isosteviol as a potassium channel opener to lower intracellular calcium concentrations in cultured aortic smooth muscle cells. Planta Med. 2004 Feb;70(2):108-12. PMID: 14994186 [PubMed - in process] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&li st_uids=14994186 Chan P, Tomlinson B, Chen YJ, Liu JC, Hsieh MH, Cheng JT. A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension. Br J Clin Pharmacol. 2000 Sep;50(3):215-20. PMID: 10971305 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=109713 05&dopt=Abstract Hsieh MH, Chan P, Sue YM, Liu JC, Liang TH, Huang TY, Tomlinson B, Chow MS, Kao PF, Chen YJ. Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: A two-year, randomized, placebo-controlled study. Clin Ther. 2003 Nov;25(11):2797-808. PMID: 14693305 [PubMed - in process] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=146933 05&dopt=Abstract Gregersen S, Jeppesen PB, Holst JJ, Hermansen K. Antihyperglycemic effects of stevioside in type 2 diabetic subjects. Metabolism. 2004 Jan;53(1):73-6. PMID: 14681845 [PubMed - in process] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=146818 45&dopt=Abstract Anti-viral activity related reference ------------------------------------- Takahashi K, Matsuda M, Ohashi K, Taniguchi K, Nakagomi O, Abe Y, Mori S, Sato N, Okutani K, Shigeta S. Analysis of anti-rotavirus activity of extract from Stevia rebaudiana. Antiviral Res. 2001 Jan;49(1):15-24. PMID: 11166857 [PubMed - indexed for MEDLINE] URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=111668 57&dopt=Abstract Links to stevia articles on the web ----------------------------------- Herbal tea lowers blood pressure, say doctors The China Post, Monday, April 2, 2001 URL:http://www.taiwanheadlines.gov.tw/20010402/20010402s6.html "A doctor at Taipei's Municipal Wan Fang Hospital (MWFH) yesterday said that herbal tea made from the sweet leaves of a plant called stevia is effective in lowering high blood pressure. Dr Chen Pao-lo, a cardiologist at MWFH, said after a series of clinical studies, he has found that stevia tea not only lowers the blood pressure of patients suffering from hypertension, it also lacks the side effects normally associated with blood-pressure lowering medicine. According to Chen, stevia was originally grown in Brazil and Paraguay before it was imported to mainland China's Xinjiang for mass cultivation decades ago. Chen pointed out that even when used over a long period, stevia tea does not threaten patients' blood sugar levels. Since stevia has been used as health food for more than 20 years with no noticeable side effects, Chen reckoned the plant could be made into blood-pressure lowering medicine safely as well." The Nutraceutical Corner.........Stevia: A Sweet Choice for Some URL:http://sun.science.wayne.edu/~nfs/news/basfsp00.htm#Stevia Stevia Sweetener, a Sugar Alternative URL:http://nutrition.about.com/library/weekly/aa092099.htm Stevia Research URL:http://herbsforhealth.about.com/cs/herbsasfood/a/aa121997_2.htm Stevia : by Ray Sahelian MD , stevia sweetener stevia recipes stevia cooking URL:http://www.raysahelian.com/stevia.html Stevia, Herb Monograph - Flora Health Herb Encyclopedia URL:http://www.florahealth.com/flora/home/canada/healthinformation/encyclopedias/Stevia.asp Monograph : Stevia rebaudiana (vaatii ilmaisen rekisteröitymisen) URL:http://www.phytotherapies.org/monograph_detail.cfm?id=262 Medicinal herbFAQ Part 2/7 (etsi sivulta Stevia) URL:http://www.faqs.org/faqs/medicinal-herbs/part2/ Stevia rebaudiana URL:http://www.rain-tree.com/stevia.htm Stevia - The Natural Sweetener URL:http://www.healthy.net/nutrit/kitchen/foods/stevia.asp Stevia - Frequently asked questions URL:http://www.stepa.be/faqs.html How Sweet Is Stevia URL:http://www.life.ca/nl/83/stevia.html -- Matti Narkia |
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