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Anti-inflammatory Effects Of Omega 3 Fatty Acid In Fish Oil Linked To Lowering Of Prostaglandin - OT
http://www.sciencedaily.com/releases...0404085719.htm
Source: Federation of American Societies for Experimental Biology Anti-inflammatory Effects Of Omega 3 Fatty Acid In Fish Oil Linked To Lowering Of Prostaglandin Omega 3 fatty acids in dietary fish oil are reported to have anti-inflammatory and anti-thrombogenic and anti-arrhythmic effects in humans, but the biochemical basis for these beneficial health effects is not well understood. Now a University of Michigan biochemist reports that fish oil significantly diminishes the production and effectiveness of various prostaglandins, naturally occurring hormone-like substances that can accentuate inflammation and thrombosis. Dr. William L. Smith described his findings on April 4 at Experimental Biology 2006 in San Francisco. His presentation was part of the scientific program of the American Society for Biochemistry and Molecular Biology (ASBMB). Dietary fish oil causes its prostaglandin-lowering effects through three different mechanisms, says Dr. Smith. First, the much fewer prostaglandins are made from omega 3 fatty acids as compared to the other class of fatty acids in the body, the omega 6 family of fatty acids that originate in the diet from leafy vegetables and other plant sources. Second, the omega 3 fatty acids compete with omega 6 fatty acids for the same binding site on the COX 1 enzyme that converts the omega 6 fatty acids to prostaglandin (which is why the COX 1 enzyme and its COX 2 cousin are the targets of anti-inflammatory drugs like ibuprofen). The more omega 3 fatty acids present to block the binding sites, the fewer omega 6 fatty acids are able to be converted to prostaglandin. Third, although omega 3 fatty acids also are converted to prostaglandins, the prostaglandins formed from omega 3 are generally 2 to 50 times less active than those formed from the omega 6 fatty acids from dietary plants. The biochemical basis of other benefits of dietary fish oil -- for example, omega 3 fatty acids' impact on neuronal development and visual acuity -- are probably due to effects on biochemical pathways regulating nerve transmission. Understanding the different pathways through which omega 3 works to convert prostaglandin helps explain why the plant-based omega 6 fatty acids don't simply provide the same benefits. Because of omega 3 fatty acids' known benefits to health, especially cardiovascular health, Dr. Smith's advice is simple: eat more fish. -- Ken "Buddhism elucidates why we are sentient." "Karma means that you don't get away with anything." |
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Anti-inflammatory Effects Of Omega 3 Fatty Acid In Fish Oil Linked To Lowering Of Prostaglandin - OT
Remember your Grandma and Mom said, "Open wide eat cod-liver oil" - you can
get Omega-3 from Puritan Pride --- for cheap. http://www.puritan.com/pages/file.as...5 389&CID=128 -- Ken "Buddhism elucidates why we are sentient." "Karma means that you don't get away with anything." "Ken Kubos" wrote in message ... | http://www.sciencedaily.com/releases...0404085719.htm | | Source: Federation of American Societies for Experimental Biology | | Anti-inflammatory Effects Of Omega 3 Fatty Acid In Fish Oil Linked To | Lowering Of Prostaglandin | | Omega 3 fatty acids in dietary fish oil are reported to have | anti-inflammatory and anti-thrombogenic and anti-arrhythmic effects in | humans, but the biochemical basis for these beneficial health effects is not | well understood. Now a University of Michigan biochemist reports that fish | oil significantly diminishes the production and effectiveness of various | prostaglandins, naturally occurring hormone-like substances that can | accentuate inflammation and thrombosis. | | Dr. William L. Smith described his findings on April 4 at Experimental | Biology 2006 in San Francisco. His presentation was part of the scientific | program of the American Society for Biochemistry and Molecular Biology | (ASBMB). | | Dietary fish oil causes its prostaglandin-lowering effects through three | different mechanisms, says Dr. Smith. | | First, the much fewer prostaglandins are made from omega 3 fatty acids as | compared to the other class of fatty acids in the body, the omega 6 family | of fatty acids that originate in the diet from leafy vegetables and other | plant sources. | | Second, the omega 3 fatty acids compete with omega 6 fatty acids for the | same binding site on the COX 1 enzyme that converts the omega 6 fatty acids | to prostaglandin (which is why the COX 1 enzyme and its COX 2 cousin are the | targets of anti-inflammatory drugs like ibuprofen). The more omega 3 fatty | acids present to block the binding sites, the fewer omega 6 fatty acids are | able to be converted to prostaglandin. | | Third, although omega 3 fatty acids also are converted to prostaglandins, | the prostaglandins formed from omega 3 are generally 2 to 50 times less | active than those formed from the omega 6 fatty acids from dietary plants. | | The biochemical basis of other benefits of dietary fish oil -- for example, | omega 3 fatty acids' impact on neuronal development and visual acuity -- are | probably due to effects on biochemical pathways regulating nerve | transmission. Understanding the different pathways through which omega 3 | works to convert prostaglandin helps explain why the plant-based omega 6 | fatty acids don't simply provide the same benefits. Because of omega 3 fatty | acids' known benefits to health, especially cardiovascular health, Dr. | Smith's advice is simple: eat more fish. | | -- | Ken | | "Buddhism elucidates why we are sentient." | "Karma means that you don't get away with anything." | | | |
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