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STUDY Low Fat Diet "safer" than Low Carb Diet....???
On Mar 5, 12:18 am, Jim wrote:
Interesting study where the published abstract and the press release seem to be based largely on different papers. The paper claims that the weight loss of low fat and low carb were similar, but the actual weight loss on low carb was almost twice that of the low fat diet, and they had managed to have a low carb subject sample with significantly lower initial weight than the low fat subject sample. ...... and there is more seeming misrepresentation as well..... PUBLISHED ABSTRACT........http://hyper.ahajournals.org/cgi/con...tract/51/2/376 Benefit of Low-Fat Over Low-Carbohydrate Diet on Endothelial Health in Obesity Shane A. Phillips; Jason W. Jurva; Amjad Q. Syed; Amina Q. Syed; Jacquelyn P. Kulinski; Joan Pleuss; Raymond G. Hoffmann; David D. Gutterman From the Department of Medicine (S.A.P., J.W.J., AmjadQ.S., AminaQ.S., J.P.K., D.D.G.), Cardiovascular Center (S.A.P., J.W.J., AmjadQ.S., AminaQ.S., J.P.K., D.D.G.), and General Clinical Research Center (J.P., R.G.H.), Medical College of Wisconsin, Milwaukee; and the Department of Physical Therapy (S.A.P.), University of Illinois at Chicago. Correspondence to Shane A. Phillips, University of Illinois at Chicago, 1919 W Taylor St, Chicago, IL 60612. E-mail Obesity is associated with impaired endothelial-dependent flow-mediated dilation, a precursor to hypertension and atherosclerosis. Although dieting generally improves cardiovascular risk factors, the direct effect of different dietary strategies on vascular endothelial function is not known. The purpose of this study was to test the hypothesis that a low-fat (LF) diet improves endothelial function compared with an isocaloric low-carbohydrate (LC) diet. Obese (n=20; body mass index: 29 to 39; mean systolic blood pressu 107 to 125 mm Hg) and otherwise healthy volunteers were randomly assigned to either the American Heart Association modeled LF (30% fat calories) diet or an isocaloric LC Atkins' style diet (20 g of carbohydrates) for 6 weeks (4-week weight loss and 2-week maintenance phase). Brachial flow-mediated dilation and dilation to nitroglycerin were measured with ultrasound using automated edge detection technology (baseline, week 2, and week 6). Blood pressure, weight loss, and cholesterol profiles were measured throughout the study. Weight loss was similar in LF (100±4 to 96.1±4 kg; P0.001) and LC (95.4±4 to 89.7±4 kg; P0.001) diets...... ===================== COMMENT ========================== LF wt loss (mean) 3.9 kg [100-96.1= 3.9] LC wt loss (mean) 5.7 kg [95.4-89.7= 5.7] LC wt loss (mean) was slightly less than twice the LF wt loss, consistent with many prior published studies. ======================= end comment ================================ ....Blood pressure decreased similarly in both groups (LF: 8/5 mm Hg; LC: 12/6 mm Hg) at 6 weeks. ...... ======================== COMMENT ============== In relative terms the systolic LC BP decline was 12/8 or 50% greater than the LF systolic BP decline..... ==================== end comment ====================== .... After 6 weeks, the percentage of flow-mediated dilation improved (1.9±0.8; P0.05) in the LF diet but was reduced in the LC diet (-1.4±0.6; P0.05) versus baseline. Dilation to nitroglycerin and lipid panels was similar at 0, 2, and 6 weeks. Despite similar degrees of weight loss and changes blood pressure, LF diets improved brachial artery flow-mediated dilation over LC diets. LF diets may confer greater cardiovascular protection than LC diets. -------------------------------------------------------------- PRESS RELEASE CLAIMS -- sounds like a different paper than the abstract. Low-fat Diets More Likely To Reduce Risk Of Heart Disease Than Low-carb Diets ScienceDaily (Mar. 3, 2008) -- Low-fat diets are more effective in preserving and promoting a healthy cardiovascular system than low-carbohydrate, Atkins'-like diets, according to a new study by researchers at the Medical College of Wisconsin in Milwaukee. The study, published in the February edition of the scientific journal Hypertension, was led by David D. Gutterman, M.D., Northwestern Mutual Professor of Cardiology, professor of medicine and physiology, and senior associate dean of research at the Medical College. Shane Phillips, M.D., a former Cardiology faculty member at the Medical College, and now assistant professor in the department of physical therapy at the University of Illinois - Chicago, was the lead author. Public awareness of the "obesity epidemic" has resulted in various dietary weight loss strategies. In America, it is estimated that 45 percent of women and 30 percent of men diet to lose weight. "The nutrient-specific effects of these diets on cardiovascular health are largely unknown," says Dr. Gutterman. "Low-carbohydrate diets are significantly higher in total grams of fat, protein, dietary cholesterol and saturated fats than are low-fat diets. While a low-carbohydrate diet may result in weight loss and improvement in blood pressure, similar to a low-fat diet, the higher fat content is ultimately more detrimental to heart health than is the low-fat diet suggested by the American Heart Association," points out Dr. Phillips. "The higher fat content of a low-carbohydrate diet may put dieters at an increased risk of atherosclerosis (hardening of the arteries) because low-carbohydrate diets often reduce protection of the endothelium, the thin layer of cells that line the blood vessels of the circulatory system. The reduced production from the endothelium of nitric oxide, a specific chemical, puts the vessel at higher risk of abnormal thickening, greater clotting potential, and cholesterol deposition, all part of the atherosclerosis process," says Dr. Gutterman. Over a six-week period, the researchers found reduced flow-mediated dilation in the arm artery in participants who were on the low-carbohydrate diet. Reduced flow-mediated dilation, as measured in this study, is an early indicator of cardiovascular disease. On the other hand, flow-mediated dilation improved significantly in participants on the low-fat diet suggesting a healthier artery which is less prone to developing atherosclerosis. "We observed a reduction in brachial artery flow-mediated dilation after six weeks of weight loss on a low-carbohydrate, Atkins'-style diet," Dr. Gutterman says. Low-carbohydrate diets were also found to have significantly less daily folic acid than low-fat diets. Folic acid is thought to be helpful in reducing the likeliness of heart disease. This protective effect results from the antioxidant property of folic acid and its ability to lower levels of homocysteine, a naturally occurring amino acid that can be dangerous at elevated levels. ========================= COMMENT ========================= Atkins recommends vitamin supplements with the low carb diet, and specifically includes folic acid.... ======================== end comment ========================= The low-carbohydrate diet provided 20 grams of carbohydrates daily and was supplemented with protein and fat content according to the Atkins' diet recommendations. The low-fat diet provided 30 percent of the calories as fat, and was modeled after the American Heart Association's recommendations. "The composition of diet may be as important as the degree of weight loss in determining the effect of dietary interventions on vascular health," Dr. Gutterman notes. Twenty participants between the ages of 18 to 50 with a body mass index ranging from 29 to 39 were monitored for the study, and the type of diet was randomly assigned to participants. Weight loss, flow-mediated dilation, blood pressure and insulin and glucose levels in the participants were measured every two weeks for the six-week study. The study was funded by the support of the National Institutes of Health General Clinical Research Center and the Medical College of Wisconsin Cardiovascular Center. It was conducted at Froedtert Hospital, the College's major teaching affiliate. Co-authors of the study included Jason Jurva, M.D., assistant professor of medicine; Amjad Syed, resident in surgery (University of Illinois -- Chicago); Amina Syed, resident in family practice with the Medical College of Wisconsin Affiliated Hospitals; Jacquelyn Kulinski, senior medical student; Joan Pleuss, senior research dietician; and Raymond Hoffmann, Ph.D., professor of population health in the division of biostatistics. Try HERBALIFE.. It's a protein diet scheme. Really works for me. And best of all, it is healthy !!! Want to know more..Email me at |
#3
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STUDY Low Fat Diet "safer" than Low Carb Diet....???
On Mar 4, 10:18 am, Jim wrote:
Interesting study where the published abstract and the press release seem to be based largely on different papers. The paper claims that the weight loss of low fat and low carb were similar, but the actual weight loss on low carb was almost twice that of the low fat diet, and they had managed to have a low carb subject sample with significantly lower initial weight than the low fat subject sample. ...... and there is more seeming misrepresentation as well..... PUBLISHED ABSTRACT........http://hyper.ahajournals.org/cgi/con...tract/51/2/376 Benefit of Low-Fat Over Low-Carbohydrate Diet on Endothelial Health in Obesity Shane A. Phillips; Jason W. Jurva; Amjad Q. Syed; Amina Q. Syed; Jacquelyn P. Kulinski; Joan Pleuss; Raymond G. Hoffmann; David D. Gutterman From the Department of Medicine (S.A.P., J.W.J., AmjadQ.S., AminaQ.S., J.P.K., D.D.G.), Cardiovascular Center (S.A.P., J.W.J., AmjadQ.S., AminaQ.S., J.P.K., D.D.G.), and General Clinical Research Center (J.P., R.G.H.), Medical College of Wisconsin, Milwaukee; and the Department of Physical Therapy (S.A.P.), University of Illinois at Chicago. Correspondence to Shane A. Phillips, University of Illinois at Chicago, 1919 W Taylor St, Chicago, IL 60612. E-mail Obesity is associated with impaired endothelial-dependent flow-mediated dilation, a precursor to hypertension and atherosclerosis. Although dieting generally improves cardiovascular risk factors, the direct effect of different dietary strategies on vascular endothelial function is not known. The purpose of this study was to test the hypothesis that a low-fat (LF) diet improves endothelial function compared with an isocaloric low-carbohydrate (LC) diet. Obese (n=20; body mass index: 29 to 39; mean systolic blood pressu 107 to 125 mm Hg) and otherwise healthy volunteers were randomly assigned to either the American Heart Association modeled LF (30% fat calories) diet or an isocaloric LC Atkins' style diet (20 g of carbohydrates) for 6 weeks (4-week weight loss and 2-week maintenance phase). Brachial flow-mediated dilation and dilation to nitroglycerin were measured with ultrasound using automated edge detection technology (baseline, week 2, and week 6). Blood pressure, weight loss, and cholesterol profiles were measured throughout the study. Weight loss was similar in LF (100±4 to 96.1±4 kg; P0.001) and LC (95.4±4 to 89.7±4 kg; P0.001) diets...... ===================== COMMENT ========================== LF wt loss (mean) 3.9 kg [100-96.1= 3.9] LC wt loss (mean) 5.7 kg [95.4-89.7= 5.7] LC wt loss (mean) was slightly less than twice the LF wt loss, consistent with many prior published studies. ======================= end comment ================================ ....Blood pressure decreased similarly in both groups (LF: 8/5 mm Hg; LC: 12/6 mm Hg) at 6 weeks. ...... ======================== COMMENT ============== In relative terms the systolic LC BP decline was 12/8 or 50% greater than the LF systolic BP decline..... ==================== end comment ====================== .... After 6 weeks, the percentage of flow-mediated dilation improved (1.9±0.8; P0.05) in the LF diet but was reduced in the LC diet (-1.4±0.6; P0.05) versus baseline. Dilation to nitroglycerin and lipid panels was similar at 0, 2, and 6 weeks. Despite similar degrees of weight loss and changes blood pressure, LF diets improved brachial artery flow-mediated dilation over LC diets. LF diets may confer greater cardiovascular protection than LC diets. -------------------------------------------------------------- PRESS RELEASE CLAIMS -- sounds like a different paper than the abstract. Low-fat Diets More Likely To Reduce Risk Of Heart Disease Than Low-carb Diets ScienceDaily (Mar. 3, 2008) -- Low-fat diets are more effective in preserving and promoting a healthy cardiovascular system than low-carbohydrate, Atkins'-like diets, according to a new study by researchers at the Medical College of Wisconsin in Milwaukee. The study, published in the February edition of the scientific journal Hypertension, was led by David D. Gutterman, M.D., Northwestern Mutual Professor of Cardiology, professor of medicine and physiology, and senior associate dean of research at the Medical College. Shane Phillips, M.D., a former Cardiology faculty member at the Medical College, and now assistant professor in the department of physical therapy at the University of Illinois - Chicago, was the lead author. Public awareness of the "obesity epidemic" has resulted in various dietary weight loss strategies. In America, it is estimated that 45 percent of women and 30 percent of men diet to lose weight. "The nutrient-specific effects of these diets on cardiovascular health are largely unknown," says Dr. Gutterman. "Low-carbohydrate diets are significantly higher in total grams of fat, protein, dietary cholesterol and saturated fats than are low-fat diets. While a low-carbohydrate diet may result in weight loss and improvement in blood pressure, similar to a low-fat diet, the higher fat content is ultimately more detrimental to heart health than is the low-fat diet suggested by the American Heart Association," points out Dr. Phillips. "The higher fat content of a low-carbohydrate diet may put dieters at an increased risk of atherosclerosis (hardening of the arteries) because low-carbohydrate diets often reduce protection of the endothelium, the thin layer of cells that line the blood vessels of the circulatory system. The reduced production from the endothelium of nitric oxide, a specific chemical, puts the vessel at higher risk of abnormal thickening, greater clotting potential, and cholesterol deposition, all part of the atherosclerosis process," says Dr. Gutterman. Over a six-week period, the researchers found reduced flow-mediated dilation in the arm artery in participants who were on the low-carbohydrate diet. Reduced flow-mediated dilation, as measured in this study, is an early indicator of cardiovascular disease. On the other hand, flow-mediated dilation improved significantly in participants on the low-fat diet suggesting a healthier artery which is less prone to developing atherosclerosis. "We observed a reduction in brachial artery flow-mediated dilation after six weeks of weight loss on a low-carbohydrate, Atkins'-style diet," Dr. Gutterman says. Low-carbohydrate diets were also found to have significantly less daily folic acid than low-fat diets. Folic acid is thought to be helpful in reducing the likeliness of heart disease. This protective effect results from the antioxidant property of folic acid and its ability to lower levels of homocysteine, a naturally occurring amino acid that can be dangerous at elevated levels. ========================= COMMENT ========================= Atkins recommends vitamin supplements with the low carb diet, and specifically includes folic acid.... ======================== end comment ========================= The low-carbohydrate diet provided 20 grams of carbohydrates daily and was supplemented with protein and fat content according to the Atkins' diet recommendations. The low-fat diet provided 30 percent of the calories as fat, and was modeled after the American Heart Association's recommendations. "The composition of diet may be as important as the degree of weight loss in determining the effect of dietary interventions on vascular health," Dr. Gutterman notes. Twenty participants between the ages of 18 to 50 with a body mass index ranging from 29 to 39 were monitored for the study, and the type of diet was randomly assigned to participants. Weight loss, flow-mediated dilation, blood pressure and insulin and glucose levels in the participants were measured every two weeks for the six-week study. The study was funded by the support of the National Institutes of Health General Clinical Research Center and the Medical College of Wisconsin Cardiovascular Center. It was conducted at Froedtert Hospital, the College's major teaching affiliate. Co-authors of the study included Jason Jurva, M.D., assistant professor of medicine; Amjad Syed, resident in surgery (University of Illinois -- Chicago); Amina Syed, resident in family practice with the Medical College of Wisconsin Affiliated Hospitals; Jacquelyn Kulinski, senior medical student; Joan Pleuss, senior research dietician; and Raymond Hoffmann, Ph.D., professor of population health in the division of biostatistics. http://www.cspinet.org/cgi-bin/integrity.cgi David D. Gutterman, M.D., F.C.C.P., Professor of Medicine and Physiology, Medical College of Wisconsin, Milwaukee. Has stock options with Johnson & Johnson. Has a relative who is a vice-president of GlaxoSmithKline. (Chest 2004;126:1) |
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