Why a high-carb diet can kill...

Asia Pac J Clin Nutr. 2005;14 Suppl:S120.

High glycemic index carbohydrate mediates an acute proinflammatory
process as measured by NF-kappaB activation.

Dickinson S, Hancock DP, Petocz P, Brand-Miller JC.

School of Molecular and Microbial Biosciences, University of Sydney,
NSW, 2006.

Background - Some high-carbohydrate diets may increase the risk of
cardiovascular disease (CVD) by promoting hyperglycemia, oxidative
stress, endothelial dysfunction and low-grade inflammation. In this
context, the classification of carbohydrates according to their
postprandial effects (ie the glycemic index, GI) may be relevant to
prevention and management of CVD. Objectives - The present study was
designed to detect differences in postprandial NF-kappaB activation (an
acute inflammatory marker) in mononuclear cells and nitrotyrosine
levels (a marker of oxidative stress) after high vs low GI meals in 10
lean, young, healthy European Caucasian subjects (5 male, 5 female)
matched for age, BMI, waist circumference, diet and physical activity.
Design - A 50 g portion of a high GI (white bread) was compared with an
isoenergetic, macronutrient-matched portion of a low GI food (pasta)
consumed in random order after an overnight fast. Glycaemia,
insulinemia, NF-kappaB and nitrotyrosine levels were determined at 0,
60, 120 and 180 min and quantitated using the area under the curve
(AUC). Outcome - Glycemia and insulinemia were within the normal range
but 3- and nearly 4-fold higher respectively after the bread meal
compared with the pasta meal. As hypothesised, the NF-kappaB response
was 3-fold greater after the bread meal (mean +/- SEM: 69 +/- 16
optical density (OD) h) compared with the pasta meal (23 +/- 4.7 OD h).
Nitrotyrosine levels increased after the bread meal (0.67 +/- 0.49
nmoles/L) and decreased after the pasta (-0.81 +/- 0.30 nmoles/L) but
the difference did not reach statistical significance. Conclusion - The
present study shows that high GI carbohydrate, but not low GI
carbohydrate, mediates an acute proinflammatory process as measured by
NF-kappaB activity. Blunting postprandial glycemia via low GI
carbohydrate may lower CVD risk.

PMID: 16326481 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/entrez/q...81&query_hl=16

On Wed, 07 Dec 2005 19:02:59 GMT, "Katt" wrote:

Asia Pac J Clin Nutr. 2005;14 Suppl:S120.

High glycemic index carbohydrate mediates an acute proinflammatory
process as measured by NF-kappaB activation.

Dickinson S, Hancock DP, Petocz P, Brand-Miller JC.

School of Molecular and Microbial Biosciences, University of Sydney,
NSW, 2006.

Background - Some high-carbohydrate diets may increase the risk of
cardiovascular disease (CVD) by promoting hyperglycemia, oxidative
stress, endothelial dysfunction and low-grade inflammation. In this
context, the classification of carbohydrates according to their
postprandial effects (ie the glycemic index, GI) may be relevant to
prevention and management of CVD. Objectives - The present study was
designed to detect differences in postprandial NF-kappaB activation (an
acute inflammatory marker) in mononuclear cells and nitrotyrosine
levels (a marker of oxidative stress) after high vs low GI meals in 10
lean, young, healthy European Caucasian subjects (5 male, 5 female)
matched for age, BMI, waist circumference, diet and physical activity.
Design - A 50 g portion of a high GI (white bread) was compared with an
isoenergetic, macronutrient-matched portion of a low GI food (pasta)
consumed in random order after an overnight fast. Glycaemia,
insulinemia, NF-kappaB and nitrotyrosine levels were determined at 0,
60, 120 and 180 min and quantitated using the area under the curve
(AUC). Outcome - Glycemia and insulinemia were within the normal range
but 3- and nearly 4-fold higher respectively after the bread meal
compared with the pasta meal. As hypothesised, the NF-kappaB response
was 3-fold greater after the bread meal (mean +/- SEM: 69 +/- 16
optical density (OD) h) compared with the pasta meal (23 +/- 4.7 OD h).
Nitrotyrosine levels increased after the bread meal (0.67 +/- 0.49
nmoles/L) and decreased after the pasta (-0.81 +/- 0.30 nmoles/L) but
the difference did not reach statistical significance. Conclusion - The
present study shows that high GI carbohydrate, but not low GI
carbohydrate, mediates an acute proinflammatory process as measured by
NF-kappaB activity. Blunting postprandial glycemia via low GI
carbohydrate may lower CVD risk.

May lower risk..so what have we learned here? Nothing

"Katt" wrote in message
news
Asia Pac J Clin Nutr. 2005;14 Suppl:S120.

High glycemic index carbohydrate mediates an acute proinflammatory
process as measured by NF-kappaB activation.

Dickinson S, Hancock DP, Petocz P, Brand-Miller JC.

School of Molecular and Microbial Biosciences, University of Sydney,
NSW, 2006.

Background - Some high-carbohydrate diets may increase the risk of


Cuting and pasting stuff you know nothing about may also kill!

Low carb diets have their own risk profile.

Low carb diets have their own risk profile. The world is not black
and white. As an example, (healthy) internal organs depicted in
medical textbooks are not representative of ALL (healthy) internal
organs. They come in all shapes and sizes!

On Wed, 07 Dec 2005 16:17:58 -0500, Susan
wrote:


On the contrary, there are a zillion studies demonstrating that higher
glycemic load diets promote heart disease, certain cancers, insulin
resistance, diabetes and inflammation.

Yes zillions of studies and now another one that shows us what? The
same thing. Whole grains are better than refined flour. It has
already been shown that one can live a long healthy life on a diet
consisting primarily on carbs that are unrefined.

In human nutrition, there is no essential carbohydrate, only essential
fats and proteins.

Yes we have already heard this from TC and yes there is no essential
carb as any carb will do but they are needed as a macronutirent and
better that they are healthy carbs than from poptarts.

Glassman wrote:
|| "Katt" wrote in message
|| news ||| Asia Pac J Clin Nutr. 2005;14 Suppl:S120.
|||
||| High glycemic index carbohydrate mediates an acute proinflammatory
||| process as measured by NF-kappaB activation.
|||
||| Dickinson S, Hancock DP, Petocz P, Brand-Miller JC.
|||
||| School of Molecular and Microbial Biosciences, University of Sydney,
||| NSW, 2006.
|||
||| Background - Some high-carbohydrate diets may increase the risk of
|||
||
|| Cuting and pasting stuff you know nothing about may also kill!

HUH????????

--
Peter
Website: http://users.thelink.net/marengo

On Wed, 07 Dec 2005 21:45:07 -0500, Susan
wrote:

Yes we have already heard this from TC and yes there is no essential
carb as any carb will do but they are needed as a macronutirent and
better that they are healthy carbs than from poptarts.

No, they are not needed as a macronutrient. Look up "essential" as it
pertains to human nutrition. Only fat and protein are needed.

Try running a marathon or even 5 miles a day and tell me carbs are not
needed. Either one is not equivalent with what early man needed for
energy.

"jt" wrote in message
...

Try running a marathon or even 5 miles a day and tell me carbs are not
needed. Either one is not equivalent with what early man needed for
energy.

Humans can adapt readily to do things like running 5 miles on pretty much
any type of diet, including one that is very low in CHO. There is reason for
this, in that some of our ancestors in northern climates would have had to
subsist primarily on game, during cold times of year when fruit was not
available and limited stores of seeds and similar were used up.

This is confirmed by all the low-carbers who are quite able to exercise,
even for long periods of time, on a low-carb diet. This does appear to
require a period of adaptation, however, especially for someone who has been
eating a high-CHO diet for a lifetime. Personally, I found I had better
stamina on a low-CHO diet than on a high-CHO diet. Granted I was doing
moderate-intensity aerobic exercise, but my stamina was definitely enhanced.
In the past there's been some good information posted in both asdl-c and smn
about low-CHO training-based enhancement of the body's abilility to store
and use fatty acids for muscular activity

There's no question that increasing CHO intake can enhance performance for
many, especially for high-intensity anaerobic activities, including repeated
lifting of heavy weights. But an adapted individual can still do quite well
with a relatively low CHO intake.

HG

"Susan" wrote in message
...

jt wrote:

Yes zillions of studies and now another one that shows us what?

Huh?

Well, Susan, apparently not everyone is interested in seeing yet another
mechanism demonstrated. 8-)

Personally I found the abstract really interesting. There's been a lot of
talk for the last few years about the importance of inflammation in
development of coronary heart disease. The studies coming along that
indicate various ways inflammation occurs are, to my mind, pretty important.
But that's just me.

HG