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Should elderly people be afraid of cholesterol?
On 24 May 2005 19:31:00 GMT, Ignoramus19430
wrote: In elderly people, low cholesterol is associated with HIGHER mortality. Why that is so, remains to be explained, but I find this to be rather interesting. For fairness, it must be said that correlation is not causation and low cholesterol could be a symptom of something else that causes elderly people who have low cholesterol to die more frequently. Cholesterol either does not cause or is only marginally related to heart disease for anyone. It's a myth. http://www.thincs.org/ -- Bob M remove ".x" to reply |
#2
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It's really dreadfully simple but few seem to get the correct direction
of cause and effect here. The illnesses (such as cancer)that precede death and the symptoms produced by these illnesses and their treatments (such as loss of appetite) also generally lower cholesterol. In other words, low cholesterol levels do not cause (note the word cause) an increased risk of death and I defy anyone to quote any study that proves otherwise. Some dangerous misinformation is now being widely spread by people who should know better. Comments are welcome. Ignoramus19430 wrote: In elderly people, low cholesterol is associated with HIGHER mortality. Why that is so, remains to be explained, but I find this to be rather interesting. For fairness, it must be said that correlation is not causation and low cholesterol could be a symptom of something else that causes elderly people who have low cholesterol to die more frequently. [Risk factors for requiring long-term care among middle-aged and elderly people] Gohgi Y, Une H. Risk factors significantly associated with higher all-cause mortality were age, low BMI, low total cholesterol, liver dysfunction, and smoking among males and females, as well as urine sugar among males and anemia among females. PMID: 15859121 Relationship between plasma lipids and all-cause mortality in nondemented elderly. Schupf N, Costa R, Luchsinger J, Tang MX, Lee JH, Mayeux R. RESULTS: Nondemented elderly with levels of total cholesterol, non-HDL-C, and LDL-C in the lowest quartile were approximately twice as likely to die as those in the highest quartile (rate ratio (RR)=1.8, 95% confidence interval (CI)=1.3-2.4). These results did not vary when analyses were adjusted for body mass index, APOE genotype, diabetes mellitus, heart disease, hypertension, stroke, diagnosis of cancer, current smoking status, or demographic variables. PMID: 15673344 High levels of C-reactive protein with low total cholesterol concentrations additively predict all-cause mortality in patients with coronary artery disease. Janoskuti L, Forhecz Z, Hosszufalusi N, Kleiber M, Walentin S, Balint O, Duba J, Rugonfalvi-Kiss S, Romics L, Karadi I, Fust G, Prohaszka Z. CONCLUSIONS: High CRP levels and low TC concentrations are independent and additive predictors of mortality in patients with CAD. PMID: 15667581 High-density vs low-density lipoprotein cholesterol as the risk factor for coronary artery disease and stroke in old age. Weverling-Rijnsburger AW, Jonkers IJ, van Exel E, Gussekloo J, Westendorp RG. A high total serum cholesterol level does not carry a risk of cardiovascular mortality among people 85 years and older and is related to decreased all-cause mortality. ... RESULTS: During 4 years of follow-up, 152 subjects died. The leading cause of death was cardiovascular disease, with similar mortality risks in all tertiles of LDL cholesterol level. In contrast, low HDL cholesterol level was associated with a 2.0-fold higher risk of fatal cardiovascular disease (95% confidence interval [CI], 1.2-3.2). The mortality risk of coronary artery disease was 2.0 (95% CI, 1.0-3.9) and for stroke it was 2.6 (95% CI, 1.0-6.6). Both low LDL cholesterol and low HDL cholesterol concentrations were associated with an increased mortality risk of infection: 2.7 (95% CI, 1.2-6.2) and 2.4 (95% CI, 1.1-5.6), respectively. The risks were unaffected by comorbidity. CONCLUSION: In contrast to high LDL cholesterol level, low HDL cholesterol level is a risk factor for mortality from coronary artery disease and stroke in old age. PMID: 12860577 |
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