Effects of a carbohydrate-restricted diet on emerging plasma markers for cardiovascular disease.

http://www.nutritionandmetabolism.com/content/3/1/19

Effects of a carbohydrate-restricted diet on emerging plasma markers for
cardiovascular disease.
Richard J. Wood , Jeff S. Volek , Steven R. Davis , Carly Dell'Ova and
Maria Luz Fernandez

Nutrition & Metabolism 2006, 3:19 doi:10.1186/1743-7075-3-19

Published 4 May 2006

Abstract (provisional)



Background

Increasing evidence supports carbohydrate restricted diets (CRD) for weight
loss and improvement in traditional markers for cardiovascular disease
(CVD); less is known regarding emerging CVD risk factors. We previously
reported that a weight loss intervention based on a CRD (%
carbohydrate:fatrotein = 13:60:27) led to a mean weight loss of 7.5 kg and
a 20% reduction of abdominal fat in 29 overweight men. This group showed
reduction in plasma LDL-cholesterol and triglycerides and elevations in
HDL-cholesterol as well as reductions in large and medium VLDL particles and
increases in LDL particle size. In this study we report on the effect of
this intervention with and without fiber supplementation on plasma
homocysteine, lipoprotein (a) [Lp(a)], C-reactive protein (CRP),
interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-alpha).

Methods

Twenty nine overweight men [body mass index (BMI) 25-35 kg/m2] aged 20-69
years consumed an ad libitum CRD (% carbohydrate:fatrotein = 13:60:27)
including a standard multivitamin every other day for 12 wk. Subjects were
matched by age and BMI and randomly assigned to consume 3 g/d of either a
soluble fiber supplement (n = 14) or placebo (n =15).

Results

There were no group or interaction (fiber x time) main effects, but
significant time effects were observed for several variables. Energy intake
was spontaneously reduced (-30.5%). This was accompanied by an increase in
protein intake (96.2 29.8g/d to 107.3 29.7 g/d) and methionine intake (2.25
0.7g/d, to 2.71 0.78 g/d; P 0.001). Trans fatty acid intake was
significantly reduced (-38.6%) while dietary folate was unchanged, as was
plasma homocysteine. Bodyweight (-7.5 2.5 kg) was reduced as was plasma
Lp(a) (-11.3%). Changes in plasma Lp(a) correlated with reductions in
LDL-cholesterol (r = .436, P 0.05) and fat loss (r = .385, P 0,05). At
wk 12, both CRP (-8.1%) and TNF-alpha (-9.3%) were reduced (P 0.05)
independently of weight loss. IL-6 concentrations were unchanged.

Conclusions

A diet based on restricting carbohydrates leads to spontaneous caloric
reduction and subsequent improvement in emerging markers of CVD in
overweight/obese men who are otherwise healthy.

Marengo wrote:
:: On Fri, 5 May 2006 06:46:36 -0400, "Roger Zoul"
:: wrote:
::
::: http://www.nutritionandmetabolism.com/content/3/1/19

snip

::: Conclusions
:::
::: A diet based on restricting carbohydrates leads to spontaneous
::: caloric reduction and subsequent improvement in emerging markers of
::: CVD in overweight/obese men who are otherwise healthy.
:::
::
:: I'm sure that means something good, but there are too many big words
:: for my ketone-fed brain!

Roger Zoul wrote:
Marengo wrote:
:: On Fri, 5 May 2006 06:46:36 -0400, "Roger Zoul"
:: wrote:
::
::: http://www.nutritionandmetabolism.com/content/3/1/19

snip

::: Conclusions
:::
::: A diet based on restricting carbohydrates leads to spontaneous
::: caloric reduction and subsequent improvement in emerging markers of
::: CVD in overweight/obese men who are otherwise healthy.
:::
::
:: I'm sure that means something good, but there are too many big words
:: for my ketone-fed brain!



It means if you're fat and you low carb you're likely to
eat less, lose weight, and decrease your cardiovascular
disease risk.
--