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Metformin question
After walking off 50 lbs over a couple of years I started metformin. I
didn't change my diet or exercise but gained 30 lbs back in 3 months. When I stoped taking metformin my weight gain stoped but those 30 lbs stayed with me so I don't think it was watter weight gain. I know metformin usualy helps people lose a few pounds I just wonder why it caused ME to gain weight. At the time my A1C was 6.1 my colesterol was about 190 with a tri. of ~121 LDL ~115 HDL ~60 I don't rember the exact numbers. Anyone know why it could have caused me to gain weight? |
#2
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Metformin question
On 2011-01-01 03:33, Woody wrote:
After walking off 50 lbs over a couple of years I started metformin. I didn't change my diet or exercise but gained 30 lbs back in 3 months. When I stoped taking metformin my weight gain stoped but those 30 lbs stayed with me so I don't think it was watter weight gain. I know metformin usualy helps people lose a few pounds I just wonder why it caused ME to gain weight. At the time my A1C was 6.1 my colesterol was about 190 with a tri. of ~121 LDL ~115 HDL ~60 I don't rember the exact numbers. Anyone know why it could have caused me to gain weight? Were you taking other drugs that could interact with metformin? GLUCOPHAGE and GLUCOPHAGE XR have the same active ingredient. However, GLUCOPHAGE XR works longer in your body. Both of these medicines help control your blood sugar in a number of ways. These include helping your body respond better to the insulin it makes naturally, decreasing the amount of sugar your liver makes, and decreasing the amount of sugar your intestines absorb. GLUCOPHAGE and GLUCOPHAGE XR do not cause your body to make more insulin. Because of this, when taken alone, they rarely cause hypoglycemia (low blood sugar), and usually do not cause weight gain. However, when they are taken with a sulfonylurea or with insulin, hypoglycemia is more likely to occur, as is weight gain |
#3
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Metformin question
On Jan 1, 3:13*pm, pamela wrote:
On 2011-01-01 03:33, Woody wrote: After walking off 50 lbs over a couple of years I started metformin. I didn't change my diet or exercise but gained 30 lbs back in 3 months. *When I stoped taking metformin my weight gain stoped but those 30 lbs stayed with me so I don't think it was watter weight gain. *I know metformin usualy helps people lose a few pounds I just wonder why it caused ME to gain weight. At the time my A1C was 6.1 * *my colesterol was about * 190 * with a tri. of ~121 * LDL ~115 HDL ~60 *I *don't rember the exact numbers. *Anyone know why it could have caused me to gain weight? Were you taking other drugs that could interact with metformin? GLUCOPHAGE and GLUCOPHAGE XR have the same active ingredient. However, GLUCOPHAGE XR works longer in your body. Both of these medicines help control your blood sugar in a number of ways. These include helping your body respond better to the insulin it makes naturally, decreasing the amount of sugar your liver makes, and decreasing the amount of sugar your intestines absorb. GLUCOPHAGE and GLUCOPHAGE XR do not cause your body to make more insulin. Because of this, when taken alone, they rarely cause hypoglycemia (low blood sugar), and usually do not cause weight gain. However, when they are taken with a sulfonylurea or with insulin, hypoglycemia is more likely to occur, as is weight gain I was not taking any other diabetic medications I still wish I could take it but that 30 lb weight gain in 3 months sure told me it wasn't for me! |
#4
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Metformin question
Woody wrote:
After walking off 50 lbs over a couple of years I started metformin. I didn't change my diet or exercise but gained 30 lbs back in 3 months. This dispoves the simplistic idea that "Calories in equals calories out". The real equation is "grams of fat into storage minus grams of fat out of storage plus/minus water retention noise level equals weight change". Anywhere near the metastability of healthy metabolism the body can change its fuel use by hundreds of calories per day to stay at a stable size, but any change that puts a bias on the stored fat towards accumulation will trigger weight gain. The ketonuria of low carbing is a bias on the stored fat towards withdrawal that triggers weight loss. (In both cases the bias happens without hunger but is easy to interfere with, whence stalls). Others have posted that metformin effects insulin and insulin drives fat into storage. For some it biases them towards fat withdrawal. For you it biased you towards fat accumulation. When I stoped taking metformin my weight gain stoped but those 30 lbs stayed with me so I don't think it was watter weight gain. When you stopped taking the pills the bias to accumulate stopped. What did not happen was a new bias to withdraw. You can do that with controlling your carbs, with controlling your calories, with increasing your exercise. A question about timing - How slowly did those 50 pounds come off when you started walking? If it was spread out over both years that's roughly a pound every other week. That's slow enough to be below the noise level. You could be losing now at that rate for 6-8 weeks without seeing it. If it was spread out over the first year that's roughly a pound per week. That's slow enough to be below the noise level for about 3-4 weeks. Water retention bounce of 3-4 pounds is common and that's a big noise level. For the first month you might just need increased patience. Not that counting your carbs or calories or kicking up your pace a bit is going to hurt just in case ... |
#5
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Metformin question
On Jan 5, 12:32*pm, Doug Freyburger wrote:
Woody wrote: After walking off 50 lbs over a couple of years I started metformin. I didn't change my diet or exercise but gained 30 lbs back in 3 months. This dispoves the simplistic idea that "Calories in equals calories out". *The real equation is "grams of fat into storage minus grams of fat out of storage plus/minus water retention noise level equals weight change". So, change in muscle mass isn't also a possible factor with at least as much significance as water retention? Sounds like you substituted one simplistic equation, for another. Anywhere near the metastability of healthy metabolism the body can change its fuel use by hundreds of calories per day to stay at a stable size, but any change that puts a bias on the stored fat towards accumulation will trigger weight gain. The ketonuria of low carbing is a bias on the stored fat towards withdrawal that triggers weight loss. (In both cases the bias happens without hunger but is easy to interfere with, whence stalls). Others have posted that metformin effects insulin and insulin drives fat into storage. *For some it biases them towards fat withdrawal. *For you it biased you towards fat accumulation. When I stoped taking metformin my weight gain stoped but those 30 lbs stayed with me so I don't think it was watter weight gain. It's a shame he had to put on 30lbs in 3 months before figuring out something was going very wrong..... |
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