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Interesting Study
Subject: [theglycemicindex] Good article
Date: Mon, 24 May 2010 22:18:17 -0400 From: David B. Klein Reply-To: To: Link: http://www.ajcn.org/cgi/reprint/87/2/303 http://www.ajcn.org/cgi/reprint/87/2/303 *Background:* Clinical trials of low-fat diets characteristically^ produce small mean long-term weight loss but a large interindividual^ variation in response. This variation has been attributed to^ psychological and behavioral factors, although biological differences^ may also play a role.^ *Objective:* The objective was to determine whether physiologic^ differences in insulin secretion explain differences in weight^ gain among individuals consuming low- and high-fat diets.^ *Design:* Of 276 individuals followed in the Quebec Family Study^ for a mean of 6 y, we compared those in the lowest with those^ in the highest dietary fat tertiles. We performed oral-glucose-tolerance^ tests at baseline and examined the insulin concentration at^ 30 min (insulin-30) as a proxy measure of insulin secretion.^ Six-year changes in body weight and waist circumference were^ the primary endpoints. We determined the associations between^ insulin-30 and the primary endpoints by linear regression analysis,^ with adjustment for potentially confounding factors.^ *Results:* Mean changes in body weight and waist circumference^ did not differ significantly between the lowest- and highest-fat^ diet groups. However, these endpoints were strongly associated^ with insulin-30, especially among individuals consuming the^ lowest-fat diet. Insulin-30 at baseline was significantly associated^ with 6-y weight gain (/r/ = 0.51, /P/ 0.0001) and change in^ waist circumference (/r/ = 0.55, /P/ 0.0001) in the lowest^ diet fat, group (/r/ = 0.18, /P/ = 0.086), but not in the highest^ diet fat group (/r/ = 0.20, /P/ = 0.058). Individuals in the highest^ insulin-30 and lowest dietary fat group gained 1.8 kg more than^ did those in the highest insulin-30 and highest dietary fat^ group (51%; /P/ = 0.034); they gained 4.5 kg more than did those^ in the lowest insulin-30 and lowest dietary fat group (6.5-fold;^ /P/ = 0.0026).^ *Conclusion:* A proxy measure of insulin secretion strongly predicts^ changes in body weight and waist circumference over 6 y in adults,^ especially among those consuming lower-fat diets, which demonstrates^ the existence of a novel diet-phenotype interaction.^ |
#2
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Good info.Thanks!
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