Binge eating caused by faulty gene, sometimes

On Tue, 3 Aug 2004 21:18:15 +0200, "Lictor"
wrote:

"janice" wrote in message
.. .
The article refers to a pill to tame the appetite. My experience of
bingeing is that it has very little to do with hunger or appetite and
a lot to do with what goes on in the mind.

Same here... I have found out that actually listening to my appetite and
hunger (which is easier said than done) makes serious bingeing virtually
impossible. Now, bingeing means eating that extra yogourt without being
hungry - more than that and I feel so unwell I don't feel like eating more.
Bingeing is only possible when your unconscious mind managers to completely
obliterate the proper signalling your brain gets from your body; and it's
actually trully impressive how powerful and efficient the unconscious mind
is at performing that trick. That's also a purely psychological trick. I
needed no meds to do it, and I needed no meds to re-learn how to detect when
I have had my fill...
I would not take any pill to tame my appetite... Appetite is my friend, it
tells me when to eat and when to stop

Yes, Lictor, I read your earlier post when you said this and found it
interesting. I'm very aware that I don't listen to my appetite,
although having said that my digestive system is a bit screwed up from
years of bingeing and I don't often feel "genuine" hunger.

I know that the one time I took appetite suppressants, many years ago,
I still overate regardless, for reasons that presumably had nothing to
do with hunger. I would never take them again, they teach you
nothing.

I'm glad you seem to have found the right way, although you make it
sound rather easy but I'm sure it hasn't been.


janice
233/181/133

"janice" wrote in message
...
I'm glad you seem to have found the right way, although you make it
sound rather easy but I'm sure it hasn't been.

It depends on where you start... If you start right at the time when I
decided to lose weight, it was rather easy actually. If you include the
panic attacks and dealing with them in the years before, the depression
periods, quitting my two packs of cigarette a day and stuff like that, it
wasn't so easy... The great discovery was to find that all these were linked
together. And that by addressing the depression, I was also dealing with
over-eating. Or that quitting the cigarette actually taught me about my
eating habits. I think I started with trying to lose weight when I was ready
to do so, a lot had been done silently beforehand.
Another factor is that I haven't done many diets before. So, I only had my
own faults to deal with, I didn't have to deal with those of several
nutritionnists and fad diets... That also helped a bunch...

"janice" wrote in message
...
I'm glad you seem to have found the right way, although you make it
sound rather easy but I'm sure it hasn't been.

It depends on where you start... If you start right at the time when I
decided to lose weight, it was rather easy actually. If you include the
panic attacks and dealing with them in the years before, the depression
periods, quitting my two packs of cigarette a day and stuff like that, it
wasn't so easy... The great discovery was to find that all these were linked
together. And that by addressing the depression, I was also dealing with
over-eating. Or that quitting the cigarette actually taught me about my
eating habits. I think I started with trying to lose weight when I was ready
to do so, a lot had been done silently beforehand.
Another factor is that I haven't done many diets before. So, I only had my
own faults to deal with, I didn't have to deal with those of several
nutritionnists and fad diets... That also helped a bunch...

On 2 Aug 2004 17:21:54 GMT, Ignoramus2586
wrote:

Binge-eating not solely caused by poor willpower, a weak gene helped:
study

I wrote this study up about a year or so ago when it came out. The
melanocortin-4 receptor IMC4R) mutation is the most common genetic
cause of obesity. The reason for this is that it's dominantly
inherited, i.e., you only need one allele of the gene to have the
mutation expressed. There are many variations of the mutation, and
some result in more obesity than others.

In the study researchers found that the subjects with the mutation had
a higher prevalence of binge eating disorder (BED) than those without
the mutation. However, since the researchers were looking for a reason
for the obesity, they did not report data on any subjects with
bulimia. Therefore, it can't be concluded from the article that
bingeing and purging are related to MC4R.

However, just because many people with BED are free of the MC4R
mutation does not mean they don't have another unknown genetic reason
for the behavior. All causes of obesity have an environmental and a
genetic component. In some cases, the genetic component is so
overwhelming that it is all but impossible to control the obesity
(i.e., leptin mutations, leptin receptor mutations) and in others, it
is fairly easy to contain with extra effort.

FWIW,


Barbara Hirsch, Publisher
OBESITY MEDS AND RESEARCH NEWS
The latest in obesity research and weight loss drug development
http://www.obesity-news.com/

On 2 Aug 2004 17:21:54 GMT, Ignoramus2586
wrote:

Binge-eating not solely caused by poor willpower, a weak gene helped:
study

I wrote this study up about a year or so ago when it came out. The
melanocortin-4 receptor IMC4R) mutation is the most common genetic
cause of obesity. The reason for this is that it's dominantly
inherited, i.e., you only need one allele of the gene to have the
mutation expressed. There are many variations of the mutation, and
some result in more obesity than others.

In the study researchers found that the subjects with the mutation had
a higher prevalence of binge eating disorder (BED) than those without
the mutation. However, since the researchers were looking for a reason
for the obesity, they did not report data on any subjects with
bulimia. Therefore, it can't be concluded from the article that
bingeing and purging are related to MC4R.

However, just because many people with BED are free of the MC4R
mutation does not mean they don't have another unknown genetic reason
for the behavior. All causes of obesity have an environmental and a
genetic component. In some cases, the genetic component is so
overwhelming that it is all but impossible to control the obesity
(i.e., leptin mutations, leptin receptor mutations) and in others, it
is fairly easy to contain with extra effort.

FWIW,


Barbara Hirsch, Publisher
OBESITY MEDS AND RESEARCH NEWS
The latest in obesity research and weight loss drug development
http://www.obesity-news.com/

On 4 Aug 2004 20:13:14 GMT, Ignoramus11472
wrote:

That implies that a person with IMC4R mutation must have one parent
with same mutation that manifests itself in the parent's phenotype,
right?

Yes.

Didn't the study imply that 1/4 of the cases of bingeing involve MC4R
mutation? (all people with the mutation were binging, IIRC)

No, not all people with the mutation had binge eating disorder. The
percentage was higher.


Barbara Hirsch, Publisher
OBESITY MEDS AND RESEARCH NEWS
The latest in obesity research and weight loss drug development
http://www.obesity-news.com/

On 4 Aug 2004 20:13:14 GMT, Ignoramus11472
wrote:

That implies that a person with IMC4R mutation must have one parent
with same mutation that manifests itself in the parent's phenotype,
right?

Yes.

Didn't the study imply that 1/4 of the cases of bingeing involve MC4R
mutation? (all people with the mutation were binging, IIRC)

No, not all people with the mutation had binge eating disorder. The
percentage was higher.


Barbara Hirsch, Publisher
OBESITY MEDS AND RESEARCH NEWS
The latest in obesity research and weight loss drug development
http://www.obesity-news.com/

On 5 Aug 2004 01:59:26 GMT, Ignoramus11472
wrote:

In article , Barbara Hirsch wrote:
On 4 Aug 2004 20:13:14 GMT, Ignoramus11472
wrote:

That implies that a person with IMC4R mutation must have one parent
with same mutation that manifests itself in the parent's phenotype,
right?

Yes.

For clarification. If the parent has 1 gene for the MCR4 mutation
there is a 50/50 chance the child will inherit it (assuming the other
parent is not affected). If the parent has both genes, the chance is
100 percent.


Barbara Hirsch, Publisher
OBESITY MEDS AND RESEARCH NEWS
The latest in obesity research and weight loss drug development
http://www.obesity-news.com/

On 5 Aug 2004 01:59:26 GMT, Ignoramus11472
wrote:

In article , Barbara Hirsch wrote:
On 4 Aug 2004 20:13:14 GMT, Ignoramus11472
wrote:

That implies that a person with IMC4R mutation must have one parent
with same mutation that manifests itself in the parent's phenotype,
right?

Yes.

For clarification. If the parent has 1 gene for the MCR4 mutation
there is a 50/50 chance the child will inherit it (assuming the other
parent is not affected). If the parent has both genes, the chance is
100 percent.


Barbara Hirsch, Publisher
OBESITY MEDS AND RESEARCH NEWS
The latest in obesity research and weight loss drug development
http://www.obesity-news.com/

Barbara Hirsch wrote:
I wrote this study up about a year or so ago when it came out. The
melanocortin-4 receptor IMC4R) mutation is the most common genetic
cause of obesity. The reason for this is that it's dominantly
inherited, i.e., you only need one allele of the gene to have the
mutation expressed. There are many variations of the mutation, and
some result in more obesity than others.

1) It's different mutations within one gene rather than many
variations of the mutation.

2) Some of these mutations are dominant, others are not:
http://www.jci.org/cgi/content/full/106/2/271

3) There are even combinations that predispose carriers to obesity in
the heterozygote state -- one would need two different mutations for
the obesity risk to increase:
http://www.jci.org/cgi/content/full/106/2/185

DZ

In the study researchers found that the subjects with the mutation had
a higher prevalence of binge eating disorder (BED) than those without
the mutation. However, since the researchers were looking for a reason
for the obesity, they did not report data on any subjects with
bulimia. Therefore, it can't be concluded from the article that
bingeing and purging are related to MC4R.

However, just because many people with BED are free of the MC4R
mutation does not mean they don't have another unknown genetic reason
for the behavior. All causes of obesity have an environmental and a
genetic component. In some cases, the genetic component is so
overwhelming that it is all but impossible to control the obesity
(i.e., leptin mutations, leptin receptor mutations) and in others, it
is fairly easy to contain with extra effort.

FWIW,


Barbara Hirsch, Publisher
OBESITY MEDS AND RESEARCH NEWS
The latest in obesity research and weight loss drug development
http://www.obesity-news.com/