CLA helps destroy fat cells, helps with insuiln sensitivity

On 16 Jul 2004 19:52:34 GMT, Ignoramus22273
wrote:

Here's two interesting articles, all related to how certain safe
nutritional supplements help destroy fat cells, and maintain level of
beta cells responsible for insulin production.

It works very well in rodents. If you're a mouse, you should take it.

If not, read the studies on humans. CLA doesn't have any significant
effect of those.


Barbara Hirsch, Publisher
OBESITY MEDS AND RESEARCH NEWS
The latest in obesity research and weight loss drug development
http://www.obesity-news.com/

On 16 Jul 2004 19:52:34 GMT, Ignoramus22273
wrote:

Here's two interesting articles, all related to how certain safe
nutritional supplements help destroy fat cells, and maintain level of
beta cells responsible for insulin production.

It works very well in rodents. If you're a mouse, you should take it.

If not, read the studies on humans. CLA doesn't have any significant
effect of those.


Barbara Hirsch, Publisher
OBESITY MEDS AND RESEARCH NEWS
The latest in obesity research and weight loss drug development
http://www.obesity-news.com/

On Fri, 16 Jul 2004 20:13:41 GMT, Barbara Hirsch w

It works very well in rodents. If you're a mouse, you should take it.

If not, read the studies on humans. CLA doesn't have any significant
effect of those.

Here's a study that says CLA works very well on humans:

http://biz.yahoo.com/prnews/040520/dcw047a_1.html

On Fri, 16 Jul 2004 20:13:41 GMT, Barbara Hirsch w

It works very well in rodents. If you're a mouse, you should take it.

If not, read the studies on humans. CLA doesn't have any significant
effect of those.

Here's a study that says CLA works very well on humans:

http://biz.yahoo.com/prnews/040520/dcw047a_1.html

One dark day on Usenet, Barbara Hirsch said:
On 16 Jul 2004 19:52:34 GMT, Ignoramus22273
wrote:

Here's two interesting articles, all related to how certain safe
nutritional supplements help destroy fat cells, and maintain level of
beta cells responsible for insulin production.

It works very well in rodents. If you're a mouse, you should take it.

If not, read the studies on humans. CLA doesn't have any significant
effect of those.

What the dickens *is* CLA, anyway..?


--
J.J. in WA * 275/231/225 (mini)
(COLD to HOT for e-mail)

One dark day on Usenet, Barbara Hirsch said:
On 16 Jul 2004 19:52:34 GMT, Ignoramus22273
wrote:

Here's two interesting articles, all related to how certain safe
nutritional supplements help destroy fat cells, and maintain level of
beta cells responsible for insulin production.

It works very well in rodents. If you're a mouse, you should take it.

If not, read the studies on humans. CLA doesn't have any significant
effect of those.

What the dickens *is* CLA, anyway..?


--
J.J. in WA * 275/231/225 (mini)
(COLD to HOT for e-mail)

One dark day on Usenet, (byakee) said:
One dark day on Usenet, Barbara Hirsch said:
On 16 Jul 2004 19:52:34 GMT, Ignoramus22273
wrote:

Here's two interesting articles, all related to how certain safe
nutritional supplements help destroy fat cells, and maintain level of
beta cells responsible for insulin production.

It works very well in rodents. If you're a mouse, you should take it.

If not, read the studies on humans. CLA doesn't have any significant
effect of those.

What the dickens *is* CLA, anyway..?

Conjugated Linoleic Acid -- hehe, answered my own question...


--
J.J. in WA * 275/231/225 (mini)
(COLD to HOT for e-mail)

One dark day on Usenet, (byakee) said:
One dark day on Usenet, Barbara Hirsch said:
On 16 Jul 2004 19:52:34 GMT, Ignoramus22273
wrote:

Here's two interesting articles, all related to how certain safe
nutritional supplements help destroy fat cells, and maintain level of
beta cells responsible for insulin production.

It works very well in rodents. If you're a mouse, you should take it.

If not, read the studies on humans. CLA doesn't have any significant
effect of those.

What the dickens *is* CLA, anyway..?

Conjugated Linoleic Acid -- hehe, answered my own question...


--
J.J. in WA * 275/231/225 (mini)
(COLD to HOT for e-mail)

On Fri, 16 Jul 2004 20:18:35 GMT, none@ (Sped) wrote:

Here's a study that says CLA works very well on humans:

http://biz.yahoo.com/prnews/040520/dcw047a_1.html

That's not a study, it's a press release.

However, I took a look at the original study. In the first place, the
"significant decline in body weight " in the CLA group was a baseline
BMI of 28.1 ± 1.5 and 27.7 ± 1.7 at the end of a year. Baseline body
fat was 31.6 ± 5.2 and at the end of a year it was 29.9 ± 5.6.. There
was no change in LBM.

The study was also supported by Natural LTD and Cognis Nutrition and
Health. Cognis Nutrition supplies the raw materials for Tonalin CLA.
So the independence of this study is questionable.

Here are two recent reviews of the literature that describe the effect
of cla on humans as minimal:

Effect of conjugated linoleic acid on body composition and plasma
lipids in humans: an overview of the literature. Terpstra AH. Am J
Clin Nutr. 2004 Mar;79(3):352-61.

From the results section:

Body weight and composition
All the studies indicated that the administration of CLA had no
significant effect on body weight or body weight regain. After
correction for changes in body weight in the control groups, there was
a net increase in body weight due to CLA in the body weight regain
study by Kamphuis et al, and this increase ranged from 0.6 to 2.0 kg.
In the other studies, the corrected net change in body weight ranged
from an increase of 0.4 kg to a decrease of 2.2 kg. None of these
changes, however, were significant

There was a significant effect of CLA on body fat mass in only 2
studies. This effect could not be ascribed to a higher intake of CLA
in these studies than in the other studies, and there appeared to be
no relation between the dose of trans-10, cis-12 isomer, the isomer
involved in the body fat-lowering effect, and the body fat-lowering
effect. Furthermore, in these 2 studies that reported a significant
body fat-lowering effect of CLA, the subjects also participated in a
light or intensive training program or did 90 min of strenuous
exercise 3 times/wk. Thus, it is possible that exercise may have
enhanced the body fat-lowering effect of CLA.

In the studies by Berven et al, Blankson et al, and Thom et al, the
net decrease in body fat tended to be greater than the net decrease in
body weight, and in the study by Smedman and Vessby, there was a
slight net increase in body weight but a net decrease in body fat.
This finding indicates that in these studies, a change took place not
only in body fat but also in lean body mass (LBM). A net decrease in
body fat that was greater than the net decrease in body weight
indicates that there was an increase in LBM or that the decrease in
LBM was less than that in the control group, as seen in the study by
Berven et al. Furthermore, in the weight regain study by Kamphuis et
al, CLA tended to promote body weight regain after a weight-loss
regimen, and this net increase in body weight was predominantly due to
an increase in LBM.

See also:

Efficacy and safety of dietary supplements containing CLA for the
treatment of obesity: evidence from animal and human studies. Larsen
TM, et al. J Lipid Res. 2003 Dec;44(12):2234-41. Epub 2003 Aug 16.

From the results section:

No effect of CLA consumption on body weight was found in any of the 13
studies. FM was assessed in 10 studies, and three of these found a
decrease in FM. Fat-free mass (FFM) was assessed in seven studies, but
only one of these studies found a slight increase in body FFM (FFM
assumed to correspond to lean body mass). Three studies assessed
neither FM nor FFM. With respect to cardiovascular risk factors,
either no or very small changes in cholesterol levels were reported,
and no consistent changes were observed.

Only one study included direct insulin sensitivity measurements. In
this study by Riserus et al., for 12 weeks, supplementation with 3.4
g/day of purified (75%) t10,c12 resulted in a significant decrease in
insulin sensitivity (using an intravenous glucose tolerance test), an
increase in fasting plasma glucose, and a significant increase in the
concentration of C-reactive protein, a marker of inflammation and a
strong predictor of cardiovascular risk. CLA supplementation in humans
has been shown to increase urinary levels of 8-iso-PGF2-a and
15-keto-dihydro-PGF2-a, which are in vivo markers of nonenzymatic and
enzymatic lipid peroxidation and oxidative stress, processes that may
contribute to insulin resistance.

To summarize, the present data from human trials does not support any
weight loss-inducing effect of CLA, and there is no unequivocal
evidence of an effect on body fat percentage. In addition, it seems
that CLA may actually induce adverse effects, including insulin
resistance, in subjects susceptible to type 2 diabetes.

I wrote a review of my own a couple of years ago which found the same
thing that these researchers did.

FWIW,

Barbara Hirsch, Publisher
OBESITY MEDS AND RESEARCH NEWS
The latest in obesity research and weight loss drug development
http://www.obesity-news.com/

On Sat, 17 Jul 2004 01:25:52 GMT, Barbara Hirsch
wrote:

On Fri, 16 Jul 2004 20:18:35 GMT, none@ (Sped) wrote:

Here's a study that says CLA works very well on humans:

http://biz.yahoo.com/prnews/040520/dcw047a_1.html

That's not a study, it's a press release.

It's not a press release, it's a story in a mainstream news source about a
study showing that CLA helps overweight people lose fat. You can follow
the links and read the actual study for yourself.