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Article: New Drug
Just before i took an LOA I meant to post this:
An experimental drug intended to duplicate the weight-reducing effect of one member of the fen-phen diet pill combination but without the side effects has succeeded in a small clinical trial, according to the drug's developer. The developer, Arena Pharmaceuticals, said that in a midstage clinical trial, obese people who took the highest dose of the drug lost an average of 2.9 pounds after 28 days, compared with 0.7 pounds for those getting a placebo. Two lower doses of the drug did not produce a significant weight loss compared with placebo. At the start of the trial, participants weighed an average of 223 pounds. The drug, called APD356, stimulates a receptor in the brain that is thought to regulate food intake. It is the same mechanism of action of Wyeth's drug fenfluramine, which was withdrawn from the market after being linked to heart valve damage. Arena says its drug is much more specific in binding to that receptor and so should avoid the side effects. Jack Lief, Arena's chief executive, said that the company "saw nothing to give us pause" in the trial, in which heart function was monitored by echocardiography. Still, the company must do much longer trials, lasting at least one year, to rule out side effects and to be able to apply for approval of the drug, he said. Dr. Steven R. Smith, the lead investigator in the trial, said that the weight reduction from the once-a-day pill was "about where you'd expect a good drug to be at the four-week time point" though a little short of a weight loss goal of one pound a week. Dr. Smith is associate professor at the Pennington Biomedical Research Center at Louisiana State University. APD356 is the lead product for Arena, a still-unprofitable biotechnology company based in San Diego. Carol Frilegh **** Toronto , Celiac SCD 4 years There is no substitute for the right food! |
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"Ignoramus20928" wrote in message ... On Wed, 11 May 2005 07:04:43 -0400, Carol Frilegh wrote: Just before i took an LOA I meant to post this: An experimental drug intended to duplicate the weight-reducing effect of one member of the fen-phen diet pill combination but without the side effects has succeeded in a small clinical trial, according to the drug's developer. The developer, Arena Pharmaceuticals, said that in a midstage clinical trial, obese people who took the highest dose of the drug lost an average of 2.9 pounds after 28 days, compared with 0.7 pounds for those getting a placebo. I want to take that placebo... i You can't Ig, it's a carb ;-) -- Dr. Dickie Skepticult member in good standing #394-00596-438 Poking kooks with a pointy stick. "The most exciting phrase to hear in science, the one that heralds new discoveries, is not 'Eureka!' ('I found it!'), but rather 'hmm....that's funny...'" - Isaac Asimov |
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